Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936740019> ?p ?o ?g. }
- W2936740019 abstract "Neural repair after stroke involves initiation of a cellular proliferative program in the form of angiogenesis, neurogenesis, and molecular growth signals in the surrounding tissue elements. This cellular environment constitutes a niche in which regeneration of new blood vessels and new neurons leads to partial tissue repair after stroke. Cancer metastasis has similar proliferative cellular events in the brain and other organs. Do cancer and CNS tissue repair share similar cellular processes? In this study, we identify a novel role of the regenerative neurovascular niche induced by stroke in promoting brain melanoma metastasis through enhancing cellular interactions with surrounding niche components. Repair-mediated neurovascular signaling induces metastatic cells to express genes crucial to metastasis. Mimicking stroke-like conditions in vitro displays an enhancement of metastatic migration potential and allows for the determination of cell-specific signals produced by the regenerative neurovascular niche. Comparative analysis of both in vitro and in vivo expression profiles reveals a major contribution of endothelial cells in mediating melanoma metastasis. These results point to a previously undiscovered role of the regenerative neurovascular niche in shaping the tumor microenvironment and brain metastatic landscape." @default.
- W2936740019 created "2019-04-25" @default.
- W2936740019 creator A5005244551 @default.
- W2936740019 creator A5009030760 @default.
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- W2936740019 creator A5081096792 @default.
- W2936740019 creator A5082475059 @default.
- W2936740019 date "2019-04-09" @default.
- W2936740019 modified "2023-10-16" @default.
- W2936740019 title "Regeneration Enhances Metastasis: A Novel Role for Neurovascular Signaling in Promoting Melanoma Brain Metastasis" @default.
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