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• W2936752015 abstract "Introduction. Myocardial perfusion scintigraphy (MPS) with dipyridamole is an accepted method for assessment of is- chaemic heart disease, in case of contraindication to exercise testing. However, very often we observe clinical symptoms and changes in ECG while monitoring patients during the study with pharmacologic stress with dipyridamole. The aim of this study was to investigate the safety of patients diagnosed with MPS with dipyridamole. Material and methods. Twenty-five patients with stable coronary artery disease participated in a 2-day protocol (0.56 mg/ kg dipyridamole i.v. and then rest) using Tc-MIBI imaging. Continuous clinical monitoring and 12-lead serial ECG has been used since the beginning of the MPS up to 20 minutes after the examination. High-sensitive cardiac troponin I (hscTnI) concentration was measured before, four hours and the next day after stress test. Primary endpoint included hscTnI concentration above 99th percentile of the upper reference limit in second or third measurement or new persistent ST-T segment changes. Secondary endpoints were: new persistent or transient ECG changes (ST-T segment elevation or depression or negative T waves, prolongation of QRS complex, PR interval or QTc), or any drug-related adverse event. Results. The concentrations of hscTnI were below 99th percentile of the upper limit among all the patients. Primary and secondary endpoint were observed in 6 (24%) and 23 (92%) patients, respectively. Transient ST-T segment elevation occurred in 4 (16%) patients, transient ST-T segment depression or negative T wave — in 7 (25%) patients, QRS complex prolongation — in 11 (44%) patients, PR interval prolongation — in 18 (75%) patients, QTc prolongation — in 22 (88%) patients, any clinical adverse event related to dipyridamole — in 16 (64%) patients. Following endpoints were correlated with positive MPS results: ST-T segment changes, RP interval prolongation, and with a history of chest pain: ST-T seg- ment changes, QRS complex and QTc prolongation. Conclusions. MPS with dipyridamole stress is relatively safe, as hscTnI concentration remains within normal in prolon- ged observation after the examination. While there is a significant risk of minor clinical and electrocardiographic adverse events it is not related with a myocardial necrosis." @default.
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• W2936752015 date "2019-04-10" @default.
• W2936752015 modified "2023-09-23" @default.
• W2936752015 title "Bezpieczeństwo pacjentów poddawanych badaniu scyntygrafii perfuzyjnej mięśnia sercowego po obciążeniu dipirydamolem" @default.
• W2936752015 doi "https://doi.org/10.5603/fc.2019.0006" @default.
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