FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936881058> ?p ?o ?g. }

• W2936881058 abstract "Abstract Respiratory infections, such as the novel coronavirus (SARS-COV-2), and other lung injuries infect and damage the pulmonary epithelium. In the most severe cases this leads to acute respiratory distress syndrome (ARDS). Due to respiratory failure associated with ARDS, the clinical intervention is the use of mechanical ventilation. Despite the benefits of mechanical ventilators, pro-longed or misuse of these ventilators may lead to ventilation-induced lung injury (VILI). Damage caused to epithelial cells within the alveoli can lead to various types of complications and increased mortality rates. A key component of the immune response is recruitment of macrophages, immune cells that differentiate into phenotypes with unique pro- and/or anti-inflammatory roles based on the surrounding environment. An imbalance in pro- and anti-inflammatory responses can have deleterious effects on the individual’s health. To gain a greater understanding of the mechanisms of the immune response to VILI and post-ventilation outcomes, we develop a mathematical model of interactions between the immune system and site of damage while accounting for macrophage polarization. Through Latin Hypercube Sampling and available data, we generate a virtual cohort of patients with biologically feasible dynamics. We use a variety of methods to analyze the results, including a random forest decision tree algorithm and parameter sensitivity with eFAST. Analysis shows that parameters and properties of transients related to epithelial repair and M1 activation and de-activation best predicted outcome. Using this new information, we hypothesize interventions and use these treatment strategies to modulate damage in select virtual patients." @default.
• W2936881058 created "2019-04-25" @default.
• W2936881058 creator A5074179729 @default.
• W2936881058 date "2019-01-01" @default.
• W2936881058 modified "2023-09-26" @default.
• W2936881058 title "Understanding the role of macrophages in lung inflammation through mathematical modeling" @default.
• W2936881058 cites W1944977254 @default.
• W2936881058 cites W1963842765 @default.
• W2936881058 cites W1965013629 @default.
• W2936881058 cites W1967952741 @default.
• W2936881058 cites W1972402899 @default.
• W2936881058 cites W1976646654 @default.
• W2936881058 cites W1980220254 @default.
• W2936881058 cites W1987609401 @default.
• W2936881058 cites W1997255681 @default.
• W2936881058 cites W2002630156 @default.
• W2936881058 cites W2004924258 @default.
• W2936881058 cites W2019221616 @default.
• W2936881058 cites W2023691088 @default.
• W2936881058 cites W2032227357 @default.
• W2936881058 cites W2037552562 @default.
• W2936881058 cites W2038290224 @default.
• W2936881058 cites W2038669746 @default.
• W2936881058 cites W2038689279 @default.
• W2936881058 cites W2039147822 @default.
• W2936881058 cites W2047420973 @default.
• W2936881058 cites W2051948180 @default.
• W2936881058 cites W2054472394 @default.
• W2936881058 cites W2054519334 @default.
• W2936881058 cites W2062453782 @default.
• W2936881058 cites W2063410191 @default.
• W2936881058 cites W2068068744 @default.
• W2936881058 cites W2069375519 @default.
• W2936881058 cites W2071471925 @default.
• W2936881058 cites W2074171762 @default.
• W2936881058 cites W2076143794 @default.
• W2936881058 cites W2082556209 @default.
• W2936881058 cites W2089520569 @default.
• W2936881058 cites W2093852073 @default.
• W2936881058 cites W2094244393 @default.
• W2936881058 cites W2101114757 @default.
• W2936881058 cites W2110065044 @default.
• W2936881058 cites W2112915641 @default.
• W2936881058 cites W2115373139 @default.
• W2936881058 cites W2120110458 @default.
• W2936881058 cites W2125766343 @default.
• W2936881058 cites W2130017811 @default.
• W2936881058 cites W2131837548 @default.
• W2936881058 cites W2138551135 @default.
• W2936881058 cites W2141890333 @default.
• W2936881058 cites W2151868609 @default.
• W2936881058 cites W2152803686 @default.
• W2936881058 cites W2153620565 @default.
• W2936881058 cites W2154434805 @default.
• W2936881058 cites W2157600239 @default.
• W2936881058 cites W2162089683 @default.
• W2936881058 cites W2171330205 @default.
• W2936881058 cites W2177044022 @default.
• W2936881058 cites W2182355171 @default.
• W2936881058 cites W2227906064 @default.
• W2936881058 cites W2259546990 @default.
• W2936881058 cites W2342612813 @default.
• W2936881058 cites W2370454012 @default.
• W2936881058 cites W2398619883 @default.
• W2936881058 cites W2591491291 @default.
• W2936881058 cites W273955616 @default.
• W2936881058 cites W2965089130 @default.
• W2936881058 cites W3008028633 @default.
• W2936881058 cites W3011730451 @default.
• W2936881058 cites W3024409265 @default.
• W2936881058 hasPublicationYear "2019" @default.
• W2936881058 type Work @default.
• W2936881058 sameAs 2936881058 @default.
• W2936881058 citedByCount "0" @default.
• W2936881058 crossrefType "posted-content" @default.
• W2936881058 hasAuthorship W2936881058A5074179729 @default.
• W2936881058 hasBestOaLocation W29368810581 @default.
• W2936881058 hasConcept C126322002 @default.
• W2936881058 hasConcept C177713679 @default.
• W2936881058 hasConcept C202751555 @default.
• W2936881058 hasConcept C203014093 @default.
• W2936881058 hasConcept C2776348555 @default.
• W2936881058 hasConcept C2776914184 @default.
• W2936881058 hasConcept C2777080012 @default.
• W2936881058 hasConcept C2777714996 @default.
• W2936881058 hasConcept C2779244956 @default.
• W2936881058 hasConcept C55493867 @default.
• W2936881058 hasConcept C71924100 @default.
• W2936881058 hasConcept C86803240 @default.
• W2936881058 hasConcept C8891405 @default.
• W2936881058 hasConceptScore W2936881058C126322002 @default.
• W2936881058 hasConceptScore W2936881058C177713679 @default.
• W2936881058 hasConceptScore W2936881058C202751555 @default.
• W2936881058 hasConceptScore W2936881058C203014093 @default.
• W2936881058 hasConceptScore W2936881058C2776348555 @default.
• W2936881058 hasConceptScore W2936881058C2776914184 @default.
• W2936881058 hasConceptScore W2936881058C2777080012 @default.
• W2936881058 hasConceptScore W2936881058C2777714996 @default.
• W2936881058 hasConceptScore W2936881058C2779244956 @default.
• W2936881058 hasConceptScore W2936881058C55493867 @default.

• next