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- W2936901152 abstract "Background: Conventional carcinomas (CCs) which represent most colorectal carcinomas (CRCs) have no alteration in microsatellite instability (MSI) and are classified as microsatellite stable tumors (MSS) while tumors with high-grade of microsatellite instability (MSI-H) has been associated with proximal-located sporadic CRC showing MLH1 promoter methylation and BRAF mutation. MSI-H tumors present more lymphocytic infiltrate than CCs. MSI-H tumors are considered as one end-point of the so-called serrated polyp pathway. In contrast, another CRC from this pathway, the serrated adenocarcinoma (SAC), which is more frequently KRAS mutated, usually microsatellite stable (MSS) and has no lymphocytic infiltrate, is associated with a bad prognosis. Patients with MSI-H tumors have been reported to get some benefits from immunotherapy treatments while CC and SACs patients do not obtain any benefits. These differences are believed to be due to the differences in the microsatellite instability (MSS or MSI tumors). The aim of this study is to determine the IDO gene expression in the different subtypes of colorectal carcinomas." @default.
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- W2936901152 date "2019-03-01" @default.
- W2936901152 modified "2023-10-01" @default.
- W2936901152 title "Study of IDO1 gene expression in histological variants of colorectal carcinoma" @default.
- W2936901152 doi "https://doi.org/10.1016/j.ejca.2019.01.070" @default.
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