Matches in SemOpenAlex for { <https://semopenalex.org/work/W2936913202> ?p ?o ?g. }
- W2936913202 endingPage "1153" @default.
- W2936913202 startingPage "1145" @default.
- W2936913202 abstract "Abstract Sézary syndrome (SS), the leukemic variant of cutaneous T-cell lymphoma, has limited treatment options and rare occurrences of long-term remission, thus warranting research into new treatment approaches. CD47 has emerged as a promising target for multiple tumor types, but its role in SS remains unknown. Here, we show that CD47 is highly expressed on Sézary cells in the peripheral blood and skin, and the high level of CD47 expression correlates with worse overall survival (OS) in patients with SS. We also demonstrate that CD47 expression on Sézary cells is under the influence of interleukin 4 (IL-4), IL-7, and IL-13. Signal regulatory protein αFc (SIRPαFc; TTI-621), a novel CD47 decoy receptor, triggers macrophage-mediated phagocytosis of Sézary cells and, when administered in clinical trial settings, results in significant tumor load reduction. We conclude that inhibition of the CD47-SIRPα signaling pathway has therapeutic benefit for patients with SS. This trial was registered at www.clinicaltrials.gov as #NCT02663518." @default.
- W2936913202 created "2019-04-25" @default.
- W2936913202 creator A5002126535 @default.
- W2936913202 creator A5005303908 @default.
- W2936913202 creator A5006240490 @default.
- W2936913202 creator A5007598559 @default.
- W2936913202 creator A5008086243 @default.
- W2936913202 creator A5013307217 @default.
- W2936913202 creator A5021957877 @default.
- W2936913202 creator A5022743718 @default.
- W2936913202 creator A5031662456 @default.
- W2936913202 creator A5032617342 @default.
- W2936913202 creator A5054420141 @default.
- W2936913202 creator A5059935122 @default.
- W2936913202 creator A5065245287 @default.
- W2936913202 creator A5069406522 @default.
- W2936913202 creator A5070507875 @default.
- W2936913202 creator A5075903729 @default.
- W2936913202 creator A5085762700 @default.
- W2936913202 date "2019-04-08" @default.
- W2936913202 modified "2023-10-16" @default.
- W2936913202 title "Targeting CD47 in Sézary syndrome with SIRPαFc" @default.
- W2936913202 cites W1552183683 @default.
- W2936913202 cites W1566680641 @default.
- W2936913202 cites W1631519520 @default.
- W2936913202 cites W1853160207 @default.
- W2936913202 cites W1964091411 @default.
- W2936913202 cites W1966217032 @default.
- W2936913202 cites W1974738881 @default.
- W2936913202 cites W1976826370 @default.
- W2936913202 cites W1982341131 @default.
- W2936913202 cites W1982385780 @default.
- W2936913202 cites W1990908331 @default.
- W2936913202 cites W1997379610 @default.
- W2936913202 cites W2001570963 @default.
- W2936913202 cites W2002146522 @default.
- W2936913202 cites W2006159237 @default.
- W2936913202 cites W2014929652 @default.
- W2936913202 cites W2015688246 @default.
- W2936913202 cites W2015828565 @default.
- W2936913202 cites W2020441584 @default.
- W2936913202 cites W2023064301 @default.
- W2936913202 cites W2031254710 @default.
- W2936913202 cites W2039949492 @default.
- W2936913202 cites W2045009458 @default.
- W2936913202 cites W2063211029 @default.
- W2936913202 cites W2069999363 @default.
- W2936913202 cites W2072623580 @default.
- W2936913202 cites W2092246736 @default.
- W2936913202 cites W2094227293 @default.
- W2936913202 cites W2096160655 @default.
- W2936913202 cites W2097126393 @default.
- W2936913202 cites W2103746815 @default.
- W2936913202 cites W2116871245 @default.
- W2936913202 cites W2121413240 @default.
- W2936913202 cites W2140608535 @default.
- W2936913202 cites W2146127535 @default.
- W2936913202 cites W2147784618 @default.
- W2936913202 cites W2166415105 @default.
- W2936913202 cites W2171873783 @default.
- W2936913202 cites W2301114920 @default.
- W2936913202 cites W2321034019 @default.
- W2936913202 cites W2395962348 @default.
- W2936913202 cites W2481211969 @default.
- W2936913202 cites W2507664190 @default.
- W2936913202 cites W2550646651 @default.
- W2936913202 cites W2551969677 @default.
- W2936913202 cites W2592953803 @default.
- W2936913202 cites W2596636194 @default.
- W2936913202 cites W2625661423 @default.
- W2936913202 cites W2686603813 @default.
- W2936913202 cites W2770192040 @default.
- W2936913202 cites W2878837766 @default.
- W2936913202 doi "https://doi.org/10.1182/bloodadvances.2018030577" @default.
- W2936913202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6457236" @default.
- W2936913202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30962222" @default.
- W2936913202 hasPublicationYear "2019" @default.
- W2936913202 type Work @default.
- W2936913202 sameAs 2936913202 @default.
- W2936913202 citedByCount "70" @default.
- W2936913202 countsByYear W29369132022019 @default.
- W2936913202 countsByYear W29369132022020 @default.
- W2936913202 countsByYear W29369132022021 @default.
- W2936913202 countsByYear W29369132022022 @default.
- W2936913202 countsByYear W29369132022023 @default.
- W2936913202 crossrefType "journal-article" @default.
- W2936913202 hasAuthorship W2936913202A5002126535 @default.
- W2936913202 hasAuthorship W2936913202A5005303908 @default.
- W2936913202 hasAuthorship W2936913202A5006240490 @default.
- W2936913202 hasAuthorship W2936913202A5007598559 @default.
- W2936913202 hasAuthorship W2936913202A5008086243 @default.
- W2936913202 hasAuthorship W2936913202A5013307217 @default.
- W2936913202 hasAuthorship W2936913202A5021957877 @default.
- W2936913202 hasAuthorship W2936913202A5022743718 @default.
- W2936913202 hasAuthorship W2936913202A5031662456 @default.
- W2936913202 hasAuthorship W2936913202A5032617342 @default.
- W2936913202 hasAuthorship W2936913202A5054420141 @default.
- W2936913202 hasAuthorship W2936913202A5059935122 @default.