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• W2936952479 abstract "Originally, the neuropeptide α-melanocyte-stimulating hormone (α-MSH) has been described as a mediator of skin pigmentation. However, recent studies have shown that α-MSH is able to modulate inflammation in various tissues including the lung. So far, it is still not clear whether α-MSH also plays a role in allergic bronchial asthma.This study aimed at investigating the role and regulatory mechanisms of α-MSH in asthma pathogenesis.α-MSH levels were measured in bronchoalveolar lavage (BAL) fluid of asthmatic and non-asthmatic individuals as well as of healthy mice and mice with experimental asthma. Wild-type mice were sensitized to ovalbumin (OVA) and exposed to an OVA aerosol in order to induce experimental allergic asthma. α-MSH was administrated intratracheally, the α-MSH antibody intraperitoneally prior each OVA challenge. Airway inflammation, cytokine production, mucus production, airway hyperresponsiveness and receptor expression were assessed.α-MSH levels in BAL of asthmatic individuals and mice were significantly higher compared to healthy controls. In a mouse model of experimental asthma, α-MSH neutralization increased airway inflammation and mucus production, whereas local administration of α-MSH significantly reduced inflammation of the airways. The beneficial effects were further associated with decreased levels of eosinophilic chemoattractant factors that are released by MC5R-positive T helper 2 and airway epithelial cells.α-MSH acts as a regulatory factor to maintain local immune homeostasis in allergic bronchial asthma." @default.
• W2936952479 created "2019-04-25" @default.
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• W2936952479 date "2019-05-06" @default.
• W2936952479 modified "2023-10-01" @default.
• W2936952479 title "The alpha‐melanocyte‐stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma" @default.
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• W2936952479 doi "https://doi.org/10.1111/cea.13400" @default.
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