Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937074925> ?p ?o ?g. }
- W2937074925 endingPage "511" @default.
- W2937074925 startingPage "511" @default.
- W2937074925 abstract "Background: Patients with chronic obstructive pulmonary disease (COPD) often suffer from multiple morbidities, which occur in clusters and are sometimes related to accelerated aging. This study aimed to assess the disease specificity of comorbidity clusters in COPD and their association with a biomarker of accelerated aging as a potential mechanistic factor. Methods: Body composition, metabolic, cardiovascular, musculoskeletal, and psychological morbidities were objectively evaluated in 208 COPD patients (age 62 ± 7 years, 58% males, FEV1 50 ± 16% predicted) and 200 non-COPD controls (age 61 ± 7 years, 45% males). Based on their presence and severity, the morbidities were clustered to generate distinct clusters in COPD and controls. Telomere length in circulating leukocytes was compared across the clusters. Results: (co)morbidities were more prevalent in COPD patients compared to controls (3.9 ± 1.7 vs. 2.4 ± 1.5, p < 0.05). A “Psychologic” and “Cachectic” cluster were only present in the COPD population. “Less (co)morbidity”, “Cardiovascular”, and “Metabolic” clusters were also observed in controls, although with less complexity. Telomere length was reduced in COPD patients, but did not differ between the (co)morbidity clusters in both populations. Conclusions: Two COPD-specific comorbidity clusters, a “Cachectic” and “Psychologic” cluster, were identified and warrant further studies regarding their development. Accelerated aging was present across various multimorbidity clusters in COPD." @default.
- W2937074925 created "2019-04-25" @default.
- W2937074925 creator A5012297897 @default.
- W2937074925 creator A5014584088 @default.
- W2937074925 creator A5021740109 @default.
- W2937074925 creator A5022732470 @default.
- W2937074925 creator A5027158250 @default.
- W2937074925 creator A5060184325 @default.
- W2937074925 creator A5062699123 @default.
- W2937074925 creator A5067135860 @default.
- W2937074925 creator A5086322244 @default.
- W2937074925 date "2019-04-14" @default.
- W2937074925 modified "2023-10-16" @default.
- W2937074925 title "Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging" @default.
- W2937074925 cites W1513833217 @default.
- W2937074925 cites W1845447069 @default.
- W2937074925 cites W1906938096 @default.
- W2937074925 cites W1966448300 @default.
- W2937074925 cites W1972914799 @default.
- W2937074925 cites W1973034871 @default.
- W2937074925 cites W1973597670 @default.
- W2937074925 cites W1983045627 @default.
- W2937074925 cites W1985002063 @default.
- W2937074925 cites W1987138414 @default.
- W2937074925 cites W2010215689 @default.
- W2937074925 cites W2021972685 @default.
- W2937074925 cites W2026761826 @default.
- W2937074925 cites W2038686627 @default.
- W2937074925 cites W2041939910 @default.
- W2937074925 cites W2042689611 @default.
- W2937074925 cites W2049759474 @default.
- W2937074925 cites W2058213039 @default.
- W2937074925 cites W2063998910 @default.
- W2937074925 cites W2066265149 @default.
- W2937074925 cites W2083436606 @default.
- W2937074925 cites W2085549140 @default.
- W2937074925 cites W2094203991 @default.
- W2937074925 cites W2101725562 @default.
- W2937074925 cites W2106036903 @default.
- W2937074925 cites W2107732097 @default.
- W2937074925 cites W2110187836 @default.
- W2937074925 cites W2122570705 @default.
- W2937074925 cites W2122764341 @default.
- W2937074925 cites W2126525177 @default.
- W2937074925 cites W2127951128 @default.
- W2937074925 cites W2127960841 @default.
- W2937074925 cites W2131232673 @default.
- W2937074925 cites W2135441474 @default.
- W2937074925 cites W2137996072 @default.
- W2937074925 cites W2138530225 @default.
- W2937074925 cites W2139347600 @default.
- W2937074925 cites W2148092884 @default.
- W2937074925 cites W2150277491 @default.
- W2937074925 cites W2151256084 @default.
- W2937074925 cites W2152927657 @default.
- W2937074925 cites W2153811949 @default.
- W2937074925 cites W2155416296 @default.
- W2937074925 cites W2158745423 @default.
- W2937074925 cites W2161243447 @default.
- W2937074925 cites W2161568934 @default.
- W2937074925 cites W2161841978 @default.
- W2937074925 cites W2165095005 @default.
- W2937074925 cites W2166281097 @default.
- W2937074925 cites W2168133467 @default.
- W2937074925 cites W2227693155 @default.
- W2937074925 cites W2303651371 @default.
- W2937074925 cites W2465104010 @default.
- W2937074925 cites W2580357067 @default.
- W2937074925 cites W2606506418 @default.
- W2937074925 cites W2607031541 @default.
- W2937074925 cites W4241883936 @default.
- W2937074925 doi "https://doi.org/10.3390/jcm8040511" @default.
- W2937074925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6517869" @default.
- W2937074925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31013986" @default.
- W2937074925 hasPublicationYear "2019" @default.
- W2937074925 type Work @default.
- W2937074925 sameAs 2937074925 @default.
- W2937074925 citedByCount "30" @default.
- W2937074925 countsByYear W29370749252020 @default.
- W2937074925 countsByYear W29370749252021 @default.
- W2937074925 countsByYear W29370749252022 @default.
- W2937074925 countsByYear W29370749252023 @default.
- W2937074925 crossrefType "journal-article" @default.
- W2937074925 hasAuthorship W2937074925A5012297897 @default.
- W2937074925 hasAuthorship W2937074925A5014584088 @default.
- W2937074925 hasAuthorship W2937074925A5021740109 @default.
- W2937074925 hasAuthorship W2937074925A5022732470 @default.
- W2937074925 hasAuthorship W2937074925A5027158250 @default.
- W2937074925 hasAuthorship W2937074925A5060184325 @default.
- W2937074925 hasAuthorship W2937074925A5062699123 @default.
- W2937074925 hasAuthorship W2937074925A5067135860 @default.
- W2937074925 hasAuthorship W2937074925A5086322244 @default.
- W2937074925 hasBestOaLocation W29370749251 @default.
- W2937074925 hasConcept C126322002 @default.
- W2937074925 hasConcept C164866538 @default.
- W2937074925 hasConcept C1862650 @default.
- W2937074925 hasConcept C199360897 @default.
- W2937074925 hasConcept C2776780178 @default.