Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937112672> ?p ?o ?g. }
- W2937112672 abstract "Chronic carriers are the main reservoirs for the spread of typhoid fever in regions of endemicity. Salmonella Typhi forms biofilms on gallstones in order to persist. A strain with enhanced biofilm-forming ability was recovered after a nine-month chronic-carriage mouse study. After sequencing this strain and recreating some of the mutations, we could not duplicate the phenotype. The isolate did show a difference in flagella, a preference to bind to cholesterol, and a systemic virulence defect. Finally, gallbladder conditions were simulated in vitro . After 60 days, there was a 4.5-fold increase in hyperbiofilm isolates when a gallstone was present. These results indicate that Salmonella spp. can undergo genetic changes that improve persistence in gallbladder albeit at the cost of decreased virulence." @default.
- W2937112672 created "2019-04-25" @default.
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- W2937112672 date "2019-07-15" @default.
- W2937112672 modified "2023-10-08" @default.
- W2937112672 title "Pathoadaptive Alteration of <i>Salmonella</i> Biofilm Formation in Response to the Gallbladder Environment" @default.
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- W2937112672 doi "https://doi.org/10.1128/jb.00774-18" @default.
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