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• W2937121402 abstract "Abstract The secreted Ly-6/uPAR Related Protein-1 (SLURP1) is an immunomodulatory protein that promotes corneal immune- and angiogenic-privilege. Here, we have examined the influence of SLURP1 on neutrophil-vascular endothelial cell interactions using human umbilical vein endothelial cells (HUVEC) and differentiated neutrophil-like HL-60 (dHL-60) cells, or primary human neutrophils. SLURP1 blocked the tumor necrosis factor-alpha (TNF-α)-activated dHL-60 cells ( i ) binding to TNF-α-activated HUVEC with a concurrent reduction in endothelial cell adhesion molecule E-selectin, ( ii ) transmigration through TNF-α-activated confluent HUVEC monolayer by stabilizing VE-cadherin and β-catenin on endothelial cell cytoplasmic membranes, ( iii ) chemotaxis towards chemoattractant formyl Met-Leu-Phe (fMLP) coupled with their decreased polarization, and ( iv ) TNF-α-stimulated matrix metalloproteinase-9 (MMP9) expression and activity. SLURP1 also suppressed the primary human neutrophil chemotaxis, and interaction with HUVEC. Furthermore, SLURP1 suppressed fMLP-induced phosphorylation of protein kinase-B (AKT) in dHL-60 cells. Collectively, these results provide evidence that SLURP1 suppresses neutrophil ( i ) docking on HUVEC cells by decreasing endothelial cell adhesion molecule E-Selectin production, ( ii ) transmigration through HUVEC monolayer by stabilizing endothelial cell membrane localization of VE-cadherin and β-catenin complex and promoting their barrier function, and ( iii ) chemotaxis by modulating their polarization and TNF-α-stimulated MMP9 production." @default.
• W2937121402 created "2019-04-25" @default.
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• W2937121402 date "2019-04-11" @default.
• W2937121402 modified "2023-10-01" @default.
• W2937121402 title "The secreted Ly6/uPAR-related protein-1 suppresses neutrophil binding, chemotaxis, and transmigration through human umbilical vein endothelial cells" @default.
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• W2937121402 doi "https://doi.org/10.1038/s41598-019-42437-x" @default.
• W2937121402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6459912" @default.
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• W2937121402 hasPublicationYear "2019" @default.
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