Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937131317> ?p ?o ?g. }
- W2937131317 endingPage "307" @default.
- W2937131317 startingPage "301" @default.
- W2937131317 abstract "Oridonin, the major terpene isolated from Rabdosia rubescens, has been used as dietary supplement. Recently, it has been known to exhibit anti-inflammatory effect. This study we employed an in vitro model of LPS-stimulated human gingival fibroblasts to investigate the anti-inflammatory effects and mechanism of oridonin. Oridonin (10–30 μg/mL) was administrated 1 h before LPS treatment. The results showed that oridonin significantly inhibited inflammatory mediators PGE2, NO, IL-6, and IL-8 production. Immunoblotting experiments revealed that oridonin reduced the expression of phosphorylation levels of NF-κB p65 and IκBα. Furthermore, the expression of PPARγ was up-regulated by the treatment of oridonin. Further studies showed that PPARγ inhibitor GW9662 could reverse the inhibition of oridonin on PGE2, NO, IL-6, and IL-8 production. In conclusion, oridonin inhibited LPS-induced microglia activation through activating PPARγ." @default.
- W2937131317 created "2019-04-25" @default.
- W2937131317 creator A5011575328 @default.
- W2937131317 creator A5020868893 @default.
- W2937131317 creator A5079934053 @default.
- W2937131317 date "2019-07-01" @default.
- W2937131317 modified "2023-09-27" @default.
- W2937131317 title "Oridonin inhibits LPS-induced inflammation in human gingival fibroblasts by activating PPARγ" @default.
- W2937131317 cites W1494611500 @default.
- W2937131317 cites W1525531948 @default.
- W2937131317 cites W1639924204 @default.
- W2937131317 cites W1874548252 @default.
- W2937131317 cites W1927072860 @default.
- W2937131317 cites W1942466966 @default.
- W2937131317 cites W1951826532 @default.
- W2937131317 cites W1966755664 @default.
- W2937131317 cites W1972391714 @default.
- W2937131317 cites W1975110792 @default.
- W2937131317 cites W1975111991 @default.
- W2937131317 cites W1978039683 @default.
- W2937131317 cites W1980911382 @default.
- W2937131317 cites W1981972440 @default.
- W2937131317 cites W1983805610 @default.
- W2937131317 cites W1988924112 @default.
- W2937131317 cites W1996333219 @default.
- W2937131317 cites W1997146656 @default.
- W2937131317 cites W2003115027 @default.
- W2937131317 cites W2004084801 @default.
- W2937131317 cites W2008309168 @default.
- W2937131317 cites W2013144840 @default.
- W2937131317 cites W2022351216 @default.
- W2937131317 cites W2036932056 @default.
- W2937131317 cites W2043258360 @default.
- W2937131317 cites W2049197565 @default.
- W2937131317 cites W2050192510 @default.
- W2937131317 cites W2052990800 @default.
- W2937131317 cites W2053344942 @default.
- W2937131317 cites W2056210235 @default.
- W2937131317 cites W2060131875 @default.
- W2937131317 cites W2062835892 @default.
- W2937131317 cites W2064711537 @default.
- W2937131317 cites W2066894723 @default.
- W2937131317 cites W2067942093 @default.
- W2937131317 cites W2068101402 @default.
- W2937131317 cites W2073882423 @default.
- W2937131317 cites W2075264042 @default.
- W2937131317 cites W2082297136 @default.
- W2937131317 cites W2082722053 @default.
- W2937131317 cites W2085207959 @default.
- W2937131317 cites W2088776314 @default.
- W2937131317 cites W2091415746 @default.
- W2937131317 cites W2108893487 @default.
- W2937131317 cites W2111971681 @default.
- W2937131317 cites W2127113423 @default.
- W2937131317 cites W2132055765 @default.
- W2937131317 cites W2144345929 @default.
- W2937131317 cites W2150439294 @default.
- W2937131317 cites W2160297100 @default.
- W2937131317 cites W2186067809 @default.
- W2937131317 cites W2343683689 @default.
- W2937131317 cites W2346131976 @default.
- W2937131317 cites W2375760414 @default.
- W2937131317 cites W2385528667 @default.
- W2937131317 cites W2438469597 @default.
- W2937131317 cites W2517519448 @default.
- W2937131317 cites W2735993381 @default.
- W2937131317 cites W2736527669 @default.
- W2937131317 cites W2783601792 @default.
- W2937131317 cites W2794319920 @default.
- W2937131317 cites W2885626252 @default.
- W2937131317 cites W2888169816 @default.
- W2937131317 cites W2891671469 @default.
- W2937131317 cites W2900892049 @default.
- W2937131317 cites W2906802687 @default.
- W2937131317 doi "https://doi.org/10.1016/j.intimp.2019.04.006" @default.
- W2937131317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31005040" @default.
- W2937131317 hasPublicationYear "2019" @default.
- W2937131317 type Work @default.
- W2937131317 sameAs 2937131317 @default.
- W2937131317 citedByCount "15" @default.
- W2937131317 countsByYear W29371313172019 @default.
- W2937131317 countsByYear W29371313172020 @default.
- W2937131317 countsByYear W29371313172021 @default.
- W2937131317 countsByYear W29371313172022 @default.
- W2937131317 countsByYear W29371313172023 @default.
- W2937131317 crossrefType "journal-article" @default.
- W2937131317 hasAuthorship W2937131317A5011575328 @default.
- W2937131317 hasAuthorship W2937131317A5020868893 @default.
- W2937131317 hasAuthorship W2937131317A5079934053 @default.
- W2937131317 hasConcept C11960822 @default.
- W2937131317 hasConcept C170493617 @default.
- W2937131317 hasConcept C185592680 @default.
- W2937131317 hasConcept C187345961 @default.
- W2937131317 hasConcept C202751555 @default.
- W2937131317 hasConcept C203014093 @default.
- W2937131317 hasConcept C2776914184 @default.
- W2937131317 hasConcept C2777730290 @default.
- W2937131317 hasConcept C2778754761 @default.