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• W2937131971 abstract "Abstract Objective Chitosan ( CS ) and polycaprolactone ( PCL ) were added into a nerve scaffold of poly(L‐lactide acid) ( PLLA )/polypyrrole ( PP y)‐based fibre films to solve the unmatch with the nerve strength and the aseptic inflammation from PLLA . Methods Poly (L‐lactide acid)‐polycaprolactone ( PLLA / PCL ) fibre films coated with chitosan ( CS ) and polypyrrole ( PP y) were prepared by electrospinning of aligned PLLA / PCL fibres, electrochemical deposition of PP y nanoparticles and in situ doping of CS in PP y. PC 12 cells were electrically stimulated with 100 mV for 2 hours every day via CS / PP y‐ PLLA / PCL fibre film to promote the neurite growth. Results The surface conductivity and tensile strength of CS / PP y‐ PLLA / PCL fibre films were 1.03 s/m and 13 MP a, respectively. CS content in fibre films was about 7.5 mg/cm 2 , improving the pH value (reached to 5.1) of immersion solution of the fibre film at 16 days. Compared with PP y‐ PLLA / PCL fibre film, more and longer axons were grown out from PC 12 cells cultured on CS / PP y‐ PLLA / PCL fibre film, indicating the positive effect of CS in fibre film on axon growth. The cell differentiation rate and neurite length on CS / PP y‐ PLLA / PCL fibre film reached to 38% and 75 μm, respectively. These results suggest the promotion of electrical stimulation on neurite growth and alignment. Conclusions A synergistic mechanism about the promotion of CS , electrical stimulation and aligned fibres on PC 12 cells differentiation, axon outgrowth was proposed. These results indicated the potential application of CS / PP y‐ PLLA / PCL fibre film in the field of the nerve repair and regeneration." @default.
• W2937131971 created "2019-04-25" @default.
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• W2937131971 date "2019-04-11" @default.
• W2937131971 modified "2023-10-16" @default.
• W2937131971 title "Fabrication of Chitosan/Polypyrrole‐coated poly(L‐lactic acid)/Polycaprolactone aligned fibre films for enhancement of neural cell compatibility and neurite growth" @default.
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• W2937131971 doi "https://doi.org/10.1111/cpr.12588" @default.
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