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• W2937133727 endingPage "2011" @default.
• W2937133727 startingPage "2003" @default.
• W2937133727 abstract "ABSTRACT Purpose Although resistance exercise (RE) is now recognized as an adjuvant in cancer treatment because of its capacity to prevent muscle wasting, weakness, and cachexia, it is unknown whether RE can mitigate tumor development. Two solid adenocarcinoma models (Walker-256 and Ehrlich) were used to investigate the effects of RE on tumor cell proliferation, growth, and aggressiveness parameters in tumor-bearing animals’ life span. Methods Walker-256 tumor-bearing rats and Ehrlich tumor-bearing mice were subjected to RE, which consisted of climbing a ladder apparatus with loads tied to their tails. After 4 wk, animals were euthanized, and tumors were excised and assessed for tumor microenvironment evaluation such as cell proliferation and apoptosis determination, collagen deposit, and presence of malignant tumor morphology. Results Our data demonstrate that RE mitigated tumor growth and favored tumor end points such as lower Scarff–Bloom–Richardson histological grade tumor, denoting slow cell aberrant form and division, decreased tumor cell proliferation (evaluated by nucleus marked with antigen ki-67), and lower viable tumor area in both types of tumors studied. In addition, RE stimulated tumor microvessel density in Walker-256 tumor-bearing rats, but there was no change in their life span. Conclusion RE may mitigate tumor growth and tumor malignancy parameters such as lower histopathological grade, assuming less nuclear pleomorphism and mitotic cells, smaller viable tumor area, and decreased tumor cell proliferation in both adenocarcinomas. In addition, RE induced tumor vascularization." @default.
• W2937133727 created "2019-04-25" @default.
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• W2937133727 date "2019-04-13" @default.
• W2937133727 modified "2023-09-27" @default.
• W2937133727 title "Resistance Exercise Counteracts Tumor Growth in Two Carcinoma Rodent Models" @default.
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• W2937133727 doi "https://doi.org/10.1249/mss.0000000000002009" @default.
• W2937133727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30985506" @default.
• W2937133727 hasPublicationYear "2019" @default.
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