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- W2937156785 abstract "The aim of the present study was to assess the anti-ageing activity in vitro and in vivo of an active principle of natural origin, consisting of plant stem cell extract in a suitable topical formulation. We tested: cream containing 1% active principle; cream without active principle (control); pure active principle in sterile packaging. The cream samples were used for clinical testing and the pure active principle was used for in vitro testing. The first aim of the clinical tests was to ensure that the products had no toxic effects on human skin. The cream was first used for epicutaneous testing and then directly to assess its effectiveness. The subjects were 15 healthy male and female volunteers who underwent: patch test; clinical trial; measurement of skin moisture. The active ingredient of plant origin “Phytocell” was assessed using parametric models of cell reproductive activity. It was tested on the human keratinocyte cell line HaCaT cultured under standard conditions. HaCaT keratinocytes were cultured in normal medium (as control) and in medium enriched with Phytocell at increasing concentrations up to 1%. None of the concentrations tested were associated with toxic effects on the cell cultures. The capacity of Phytocell to stimulate keratinocyte proliferation and to remove contact inhibition in vitro was then estimated, the latter in terms of cell migration capacity and reduction of scratch amplitude. Our results showed that the product was well tolerated by the skin of normal subjects and had good moisturizing activity. The in vitro experiments showed that the plant extract substantially stimulated repair of damaged cell layers. This was evident at 48 h. , after which the effect tapered to zero. The study demonstrated that a rational basis exists for the use of plant stem cell extract in cosmetics. The experimental results of the clinical and in vitro testing support this working hypothesis." @default.
- W2937156785 created "2019-04-25" @default.
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- W2937156785 date "2019-05-01" @default.
- W2937156785 modified "2023-09-26" @default.
- W2937156785 title "703 Evaluation the anti-ageing and repair activity of plant stem cell extract in a topical formulation" @default.
- W2937156785 doi "https://doi.org/10.1016/j.jid.2019.03.779" @default.
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