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- W2937157005 abstract "Suppressors of cytokine signaling (SOCS) proteins provide selective negative feedback within immune cells to help prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomegalovirus, can manipulate expression of these host proteins, with overstimulation of SOCS1 and/or SOCS3 putatively facilitating viral evasion of immune surveillance, and SOCS suppression generally exacerbating immunopathogenesis. This is particularly poignant within the eye, which contains a diverse assortment of specialized cell types working together in a tightly-controlled microenvironment of immune privilege. When the immune privilege of the ocular compartment fails, inflammation causing severe immunopathogenesis and permanent, sight-threatening damage may occur, as in the case of AIDS-related human cytomegalovirus (HCMV) retinitis. Herein we review how SOCS1 and SOCS3 impact the virologic, immunologic, and/or pathologic outcomes of herpesviruses, with particular emphasis on retinitis caused by HCMV or its mouse model experimental counterpart, murine cytomegalovirus (MCMV). The accumulated data suggests that SOCS1 and/or SOCS3 can differentially affect the severity of viral diseases in a highly cell-type-specific manner which reflects the diversity and complexity of herpesvirus infection and of the ocular compartment." @default.
- W2937157005 created "2019-04-25" @default.
- W2937157005 creator A5002423834 @default.
- W2937157005 creator A5033299144 @default.
- W2937157005 date "2019-04-11" @default.
- W2937157005 modified "2023-10-14" @default.
- W2937157005 title "SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis" @default.
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