Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937199577> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2937199577 endingPage "S100" @default.
- W2937199577 startingPage "S100" @default.
- W2937199577 abstract "Immune checkpoint inhibitors have advanced cancer treatment but commonly cause cutaneous immune-related adverse events, such as skin rash and pruritus. There is limited understanding on how to characterize cutaneous adverse events and their impact on health-related quality of life (HRQOL). This systematic review aimed to assess HRQOL outcome measures in studies of immune checkpoint inhibitors and identify if impact from cutaneous adverse events were specifically captured. A systematic literature search of PubMed, Embase, and Web of Science was performed using the following search terms: immune checkpoint inhibitors (avelumab, pembrolizumab, nivolumab, ipilimumab, atezolizumab, durvalumab) and quality of life. Human subject studies in English, including case series, cohorts, or randomized clinical trials, published in 1/2008–11/2018 were included. Among 1500 studies identified on initial screening, 23 studies (22 randomized controlled trials and 1 observational cohort) met inclusion criteria. Nivolumab (12 studies), ipilimumab (6 studies), and combined treatment with both nivolumab and ipilimumab (3 studies) were the most common therapies assessed. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30) was used by 14 studies (61%) but did not contain any question related to the skin. Only 4 studies (17%) used questionnaires that included skin-related questions: 2 used the Functional Assessment of Cancer Therapy-Melanoma (FACT-M), a melanoma-specific quality of life survey that asked about melanoma surgical site (swelling, pain) and overall skin appearance; 2 used the EORTC-QLQ-LC13, which included 1 question on alopecia. In comparison, 22 of 23 studies reported at least 1 cutaneous adverse event. As the use of immune checkpoint inhibitors becomes more widespread, rigorous assessment of the skin- and itch-specific HRQOL impact from immunotherapy will be critical." @default.
- W2937199577 created "2019-04-25" @default.
- W2937199577 creator A5004611155 @default.
- W2937199577 creator A5030849116 @default.
- W2937199577 creator A5050065650 @default.
- W2937199577 creator A5060975326 @default.
- W2937199577 date "2019-05-01" @default.
- W2937199577 modified "2023-09-27" @default.
- W2937199577 title "580 Health-related quality of life measures and immune checkpoint inhibitors: A systematic review" @default.
- W2937199577 doi "https://doi.org/10.1016/j.jid.2019.03.656" @default.
- W2937199577 hasPublicationYear "2019" @default.
- W2937199577 type Work @default.
- W2937199577 sameAs 2937199577 @default.
- W2937199577 citedByCount "0" @default.
- W2937199577 crossrefType "journal-article" @default.
- W2937199577 hasAuthorship W2937199577A5004611155 @default.
- W2937199577 hasAuthorship W2937199577A5030849116 @default.
- W2937199577 hasAuthorship W2937199577A5050065650 @default.
- W2937199577 hasAuthorship W2937199577A5060975326 @default.
- W2937199577 hasBestOaLocation W29371995771 @default.
- W2937199577 hasConcept C121608353 @default.
- W2937199577 hasConcept C126322002 @default.
- W2937199577 hasConcept C143998085 @default.
- W2937199577 hasConcept C159110408 @default.
- W2937199577 hasConcept C168563851 @default.
- W2937199577 hasConcept C197934379 @default.
- W2937199577 hasConcept C23131810 @default.
- W2937199577 hasConcept C2775949291 @default.
- W2937199577 hasConcept C2777381376 @default.
- W2937199577 hasConcept C2777658100 @default.
- W2937199577 hasConcept C2777701055 @default.
- W2937199577 hasConcept C2777742743 @default.
- W2937199577 hasConcept C2779951463 @default.
- W2937199577 hasConcept C2780030458 @default.
- W2937199577 hasConcept C2780057760 @default.
- W2937199577 hasConcept C2781433595 @default.
- W2937199577 hasConcept C502942594 @default.
- W2937199577 hasConcept C535046627 @default.
- W2937199577 hasConcept C71924100 @default.
- W2937199577 hasConceptScore W2937199577C121608353 @default.
- W2937199577 hasConceptScore W2937199577C126322002 @default.
- W2937199577 hasConceptScore W2937199577C143998085 @default.
- W2937199577 hasConceptScore W2937199577C159110408 @default.
- W2937199577 hasConceptScore W2937199577C168563851 @default.
- W2937199577 hasConceptScore W2937199577C197934379 @default.
- W2937199577 hasConceptScore W2937199577C23131810 @default.
- W2937199577 hasConceptScore W2937199577C2775949291 @default.
- W2937199577 hasConceptScore W2937199577C2777381376 @default.
- W2937199577 hasConceptScore W2937199577C2777658100 @default.
- W2937199577 hasConceptScore W2937199577C2777701055 @default.
- W2937199577 hasConceptScore W2937199577C2777742743 @default.
- W2937199577 hasConceptScore W2937199577C2779951463 @default.
- W2937199577 hasConceptScore W2937199577C2780030458 @default.
- W2937199577 hasConceptScore W2937199577C2780057760 @default.
- W2937199577 hasConceptScore W2937199577C2781433595 @default.
- W2937199577 hasConceptScore W2937199577C502942594 @default.
- W2937199577 hasConceptScore W2937199577C535046627 @default.
- W2937199577 hasConceptScore W2937199577C71924100 @default.
- W2937199577 hasIssue "5" @default.
- W2937199577 hasLocation W29371995771 @default.
- W2937199577 hasOpenAccess W2937199577 @default.
- W2937199577 hasPrimaryLocation W29371995771 @default.
- W2937199577 hasRelatedWork W2750661428 @default.
- W2937199577 hasRelatedWork W2795152269 @default.
- W2937199577 hasRelatedWork W2800311363 @default.
- W2937199577 hasRelatedWork W2886091010 @default.
- W2937199577 hasRelatedWork W2968490685 @default.
- W2937199577 hasRelatedWork W3000961096 @default.
- W2937199577 hasRelatedWork W3046829154 @default.
- W2937199577 hasRelatedWork W3106449294 @default.
- W2937199577 hasRelatedWork W3109431802 @default.
- W2937199577 hasRelatedWork W4221003897 @default.
- W2937199577 hasVolume "139" @default.
- W2937199577 isParatext "false" @default.
- W2937199577 isRetracted "false" @default.
- W2937199577 magId "2937199577" @default.
- W2937199577 workType "article" @default.