FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937211469> ?p ?o ?g. }

• W2937211469 endingPage "370" @default.
• W2937211469 startingPage "361" @default.
• W2937211469 abstract "Angiopoietin-2 (Ang-2) is a multifaceted cytokine that functions in both angiogenesis and inflammation. A proangiogenic state has been found in adults with sickle cell disease (SCD), mainly because of elevated Ang-2 levels. We determined Ang-2 level in 40 children and adolescents with SCD compared with 40 healthy controls and assessed its relation to retinopathy as well as carotid intimamedia thickness (CIMT).Hematologic profile, serum ferritin, and serum Ang-2 were measured. CIMT was assessed using high-resolution ultrasound. Fundus examination was performed followed by fundus fluorescein angiography. Optical coherence tomography angiography (OCTA) was used to find small vascular changes not clinically manifested.Ang-2 levels and CIMT were significantly higher in SCD patients compared with controls. The incidence of nonproliferative retinopathy was 45%. SCD patients with retinopathy were older in age with a history of sickling crisis of >3 attacks per year and had a higher incidence of sickle cell anemia than sickle β-thalassemia. Ang-2 cutoff value 9000 pg/mL could significantly detect the presence of retinopathy among SCD patients with 100% sensitivity and specificity. Serum Ang-2 levels were positively correlated with HbS and CIMT. Logistic regression analysis revealed that Ang-2 and HbS significantly contribute to retinopathy among patients with SCD.Elevated Ang-2 highlights the role of angiogenesis in the pathophysiology of SCD and may be considered a promising marker for screening of patients at risk of sickle retinopathy and vascular dysfunction." @default.
• W2937211469 created "2019-04-25" @default.
• W2937211469 creator A5001077296 @default.
• W2937211469 creator A5018934213 @default.
• W2937211469 creator A5025725556 @default.
• W2937211469 creator A5036555114 @default.
• W2937211469 creator A5067193561 @default.
• W2937211469 creator A5068645791 @default.
• W2937211469 date "2019-07-01" @default.
• W2937211469 modified "2023-09-27" @default.
• W2937211469 title "Angiopoietin-2 as a Marker of Retinopathy in Children and Adolescents With Sickle Cell Disease: Relation to Subclinical Atherosclerosis" @default.
• W2937211469 cites W1495287184 @default.
• W2937211469 cites W1758592134 @default.
• W2937211469 cites W1963976067 @default.
• W2937211469 cites W1970380651 @default.
• W2937211469 cites W1974954205 @default.
• W2937211469 cites W1981092509 @default.
• W2937211469 cites W1982563696 @default.
• W2937211469 cites W1982955412 @default.
• W2937211469 cites W1984095718 @default.
• W2937211469 cites W1988851886 @default.
• W2937211469 cites W1999608172 @default.
• W2937211469 cites W2012886992 @default.
• W2937211469 cites W2013818100 @default.
• W2937211469 cites W2025860888 @default.
• W2937211469 cites W2027718081 @default.
• W2937211469 cites W2036884019 @default.
• W2937211469 cites W2040323431 @default.
• W2937211469 cites W2053495832 @default.
• W2937211469 cites W2062172506 @default.
• W2937211469 cites W2064429559 @default.
• W2937211469 cites W2066293079 @default.
• W2937211469 cites W2075981185 @default.
• W2937211469 cites W2086685954 @default.
• W2937211469 cites W2087758384 @default.
• W2937211469 cites W2093096968 @default.
• W2937211469 cites W2093240123 @default.
• W2937211469 cites W2093631945 @default.
• W2937211469 cites W2103163191 @default.
• W2937211469 cites W2108267327 @default.
• W2937211469 cites W2108644172 @default.
• W2937211469 cites W2113336861 @default.
• W2937211469 cites W2114223764 @default.
• W2937211469 cites W2118531218 @default.
• W2937211469 cites W2118621310 @default.
• W2937211469 cites W2132372441 @default.
• W2937211469 cites W2134604333 @default.
• W2937211469 cites W2137359256 @default.
• W2937211469 cites W2138200770 @default.
• W2937211469 cites W2150508436 @default.
• W2937211469 cites W2152215024 @default.
• W2937211469 cites W2155652067 @default.
• W2937211469 cites W2158033765 @default.
• W2937211469 cites W2167273447 @default.
• W2937211469 cites W2167426386 @default.
• W2937211469 cites W2170400006 @default.
• W2937211469 cites W2322074970 @default.
• W2937211469 cites W2405035523 @default.
• W2937211469 cites W2419074923 @default.
• W2937211469 cites W2497591559 @default.
• W2937211469 cites W2515025352 @default.
• W2937211469 cites W2590648140 @default.
• W2937211469 cites W2914437448 @default.
• W2937211469 cites W4211186710 @default.
• W2937211469 cites W4249449362 @default.
• W2937211469 cites W50870326 @default.
• W2937211469 doi "https://doi.org/10.1097/mph.0000000000001486" @default.
• W2937211469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30994508" @default.
• W2937211469 hasPublicationYear "2019" @default.
• W2937211469 type Work @default.
• W2937211469 sameAs 2937211469 @default.
• W2937211469 citedByCount "5" @default.
• W2937211469 countsByYear W29372114692020 @default.
• W2937211469 countsByYear W29372114692021 @default.
• W2937211469 countsByYear W29372114692023 @default.
• W2937211469 crossrefType "journal-article" @default.
• W2937211469 hasAuthorship W2937211469A5001077296 @default.
• W2937211469 hasAuthorship W2937211469A5018934213 @default.
• W2937211469 hasAuthorship W2937211469A5025725556 @default.
• W2937211469 hasAuthorship W2937211469A5036555114 @default.
• W2937211469 hasAuthorship W2937211469A5067193561 @default.
• W2937211469 hasAuthorship W2937211469A5068645791 @default.
• W2937211469 hasConcept C113280763 @default.
• W2937211469 hasConcept C118487528 @default.
• W2937211469 hasConcept C120665830 @default.
• W2937211469 hasConcept C121332964 @default.
• W2937211469 hasConcept C126322002 @default.
• W2937211469 hasConcept C134018914 @default.
• W2937211469 hasConcept C164705383 @default.
• W2937211469 hasConcept C2776391266 @default.
• W2937211469 hasConcept C2778248108 @default.
• W2937211469 hasConcept C2778257484 @default.
• W2937211469 hasConcept C2778271429 @default.
• W2937211469 hasConcept C2778313320 @default.
• W2937211469 hasConcept C2778620579 @default.
• W2937211469 hasConcept C2779134260 @default.
• W2937211469 hasConcept C2780248432 @default.
• W2937211469 hasConcept C2780394083 @default.

• next