FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937228220> ?p ?o ?g. }

• W2937228220 endingPage "215" @default.
• W2937228220 startingPage "206" @default.
• W2937228220 abstract "Background: IL-2 cytokine is involved in HIV replication and is also known to cause hepatic injury. Polymorphisms in the IL-2 gene are associated with altered interleukin-2 production. Methods: Hence, we assessed the prevalence of IL-2-303G/T polymorphism in 165 HIV patients (34 with and 131without hepatotoxicity) and 155 healthy controls using the PCR-RFLP method. Results: In patients with hepatotoxicity, IL-2-303GT, -303GT+TT genotypes were less prevalent as compared to without hepatotoxicity and healthy controls (29.4% vs. 42.7%, 58.8% vs. 69.5%; 29.4% vs. 40.6%, 58.8% vs. 66.5%, respectively). In patients with hepatotoxicity using tobacco and alcohol, IL-2-303GT,-303TT genotypes were distributed higher as compared to non-users (42.9% vs. 25.9%, OR=8.52, 42.9% vs. 25.9%, OR=9.09, and 28.6% vs. 29.6%, OR=1.63, 42.9% vs. 25.9%, OR=2.93), while IL-2-303TT genotype occurred more often in HIV patients consuming alcohol (34.1% vs. 23.0%). Nevirapine users with hepatotoxicity overrepresented the IL-2-303GT,-303TT genotypes as compared to efavirenz (34.8% vs. 18.2%, OR=4.64, 34.8% vs. 18.2%, OR=3.88). Among nevirapine users, IL-2-303GT genotype was associated with susceptibility to the acquisition of hepatotoxicity with borderline significance (OR=4.24, P=0.06). HIV patients using nevirapine majorly represented the IL-2-303TT genotype (26.9% vs. 25.0%, OR=2.35) while HIV patients with nevirapine + alcohol usage presented the IL-2 -330TT genotype at a higher frequency (34.2% vs. 23.5%, OR=1.51). In patients with hepatotoxicity using nevirapine + alcohol, the genotype IL-2 - 330TT was predominant (60.0% vs. 27.8%, OR=3.16). Conclusion: Thus, IL-2-303G/T polymorphism did not confer the susceptibility to ARV associated hepatotoxicity. However, IL-2-303G/T polymorphism with nevirapine usage may facilitate the risk for acquisition of ARV associated hepatotoxicity." @default.
• W2937228220 created "2019-04-25" @default.
• W2937228220 creator A5020426862 @default.
• W2937228220 creator A5043581632 @default.
• W2937228220 creator A5078427559 @default.
• W2937228220 creator A5086516475 @default.
• W2937228220 date "2019-06-10" @default.
• W2937228220 modified "2023-09-25" @default.
• W2937228220 title "Occurrence of Interleukin-2 (330 G/T) Promoter Polymorphism in ARV associated hepatotoxicity" @default.
• W2937228220 cites W1711736037 @default.
• W2937228220 cites W1963559980 @default.
• W2937228220 cites W1967468344 @default.
• W2937228220 cites W1970622835 @default.
• W2937228220 cites W1971511394 @default.
• W2937228220 cites W1985710271 @default.
• W2937228220 cites W1993412307 @default.
• W2937228220 cites W1993981679 @default.
• W2937228220 cites W2000890982 @default.
• W2937228220 cites W2014916760 @default.
• W2937228220 cites W2015835690 @default.
• W2937228220 cites W2018672348 @default.
• W2937228220 cites W2019383340 @default.
• W2937228220 cites W2022159341 @default.
• W2937228220 cites W2024727799 @default.
• W2937228220 cites W2029489281 @default.
• W2937228220 cites W2029518991 @default.
• W2937228220 cites W2029612510 @default.
• W2937228220 cites W2032722583 @default.
• W2937228220 cites W2037555606 @default.
• W2937228220 cites W2040446041 @default.
• W2937228220 cites W2043792585 @default.
• W2937228220 cites W2044634578 @default.
• W2937228220 cites W2049535135 @default.
• W2937228220 cites W2054895695 @default.
• W2937228220 cites W2067722911 @default.
• W2937228220 cites W2077040835 @default.
• W2937228220 cites W2083697259 @default.
• W2937228220 cites W2087866361 @default.
• W2937228220 cites W2092884146 @default.
• W2937228220 cites W2098279581 @default.
• W2937228220 cites W2099197288 @default.
• W2937228220 cites W2099953361 @default.
• W2937228220 cites W2119371081 @default.
• W2937228220 cites W2122483069 @default.
• W2937228220 cites W2130926067 @default.
• W2937228220 cites W2131605289 @default.
• W2937228220 cites W2136540839 @default.
• W2937228220 cites W2145368185 @default.
• W2937228220 cites W2152333135 @default.
• W2937228220 cites W2164855536 @default.
• W2937228220 cites W2275011716 @default.
• W2937228220 cites W2595452534 @default.
• W2937228220 cites W2753960447 @default.
• W2937228220 cites W2922467513 @default.
• W2937228220 doi "https://doi.org/10.2174/1566524019666190411093451" @default.
• W2937228220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30973108" @default.
• W2937228220 hasPublicationYear "2019" @default.
• W2937228220 type Work @default.
• W2937228220 sameAs 2937228220 @default.
• W2937228220 citedByCount "1" @default.
• W2937228220 countsByYear W29372282202023 @default.
• W2937228220 crossrefType "journal-article" @default.
• W2937228220 hasAuthorship W2937228220A5020426862 @default.
• W2937228220 hasAuthorship W2937228220A5043581632 @default.
• W2937228220 hasAuthorship W2937228220A5078427559 @default.
• W2937228220 hasAuthorship W2937228220A5086516475 @default.
• W2937228220 hasConcept C104317684 @default.
• W2937228220 hasConcept C126322002 @default.
• W2937228220 hasConcept C135763542 @default.
• W2937228220 hasConcept C142462285 @default.
• W2937228220 hasConcept C203014093 @default.
• W2937228220 hasConcept C2778690821 @default.
• W2937228220 hasConcept C2779130552 @default.
• W2937228220 hasConcept C2781432083 @default.
• W2937228220 hasConcept C2993143319 @default.
• W2937228220 hasConcept C3013748606 @default.
• W2937228220 hasConcept C54355233 @default.
• W2937228220 hasConcept C68239362 @default.
• W2937228220 hasConcept C71924100 @default.
• W2937228220 hasConcept C86803240 @default.
• W2937228220 hasConcept C90924648 @default.
• W2937228220 hasConceptScore W2937228220C104317684 @default.
• W2937228220 hasConceptScore W2937228220C126322002 @default.
• W2937228220 hasConceptScore W2937228220C135763542 @default.
• W2937228220 hasConceptScore W2937228220C142462285 @default.
• W2937228220 hasConceptScore W2937228220C203014093 @default.
• W2937228220 hasConceptScore W2937228220C2778690821 @default.
• W2937228220 hasConceptScore W2937228220C2779130552 @default.
• W2937228220 hasConceptScore W2937228220C2781432083 @default.
• W2937228220 hasConceptScore W2937228220C2993143319 @default.
• W2937228220 hasConceptScore W2937228220C3013748606 @default.
• W2937228220 hasConceptScore W2937228220C54355233 @default.
• W2937228220 hasConceptScore W2937228220C68239362 @default.
• W2937228220 hasConceptScore W2937228220C71924100 @default.
• W2937228220 hasConceptScore W2937228220C86803240 @default.
• W2937228220 hasConceptScore W2937228220C90924648 @default.
• W2937228220 hasIssue "3" @default.
• W2937228220 hasLocation W29372282201 @default.

• next