FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937230536> ?p ?o ?g. }

• W2937230536 abstract "Porcine circovirus-associated disease (PCVAD) is one of the most serious infectious diseases in pigs worldwide. The primary causative agent of PCVAD is porcine circovirus type 2 (PCV2), which can cause lymphoid depletion and immunosuppression in pigs. Our previous study demonstrated that Laiwu (LW) pigs, a Chinese indigenous pig breed, have stronger resistance to PCV2 infection than Yorkshire × Landrace (YL) pigs. In this study, we found that the YL pigs showed more severe lymphocyte apoptosis and higher viral load in the spleen tissue than LW pigs. To illustrate the differential gene expression between healthy and infected spleens, transcriptome profiling of spleen tissues from PCV2-infected and control YL pigs was compared by RNA sequencing. A total of 90 differentially expressed genes (DEGs) was identified, including CD207, RSAD2, OAS1, OAS2, MX2, ADRB3, CXCL13, CCR1, and ADRA2C, which were significantly enriched in gene ontology (GO) terms related to the defense response to virus and cell–cell signaling, and another nine DEGs, KLF11, HGF, PTGES3, MAP3K11, XDH, CYCS, ACTC1, HSPH1, and RYR2, which were enriched in GO terms related to regulation of cell proliferation or apoptosis. Among these DEGs, the CXCL13 gene, which can suppress lymphocyte apoptosis during PCV2 infection, was significantly down-regulated in response to PCV2 infection in YL but not in LW pigs. By analysis of the regulatory elements in the promoter and 3′-untranslated region (3′-UTR) of porcine CXCL13, we found that the single nucleotide polymorphism (SNP) −1014 G (LW) > A (YL) and the Sus scrofa microRNA-296-5p (ssc-miR-296-5p) participated in regulating CXCL13 expression during the response to PCV2 infection." @default.
• W2937230536 created "2019-04-25" @default.
• W2937230536 creator A5005616906 @default.
• W2937230536 creator A5007145458 @default.
• W2937230536 creator A5010165168 @default.
• W2937230536 creator A5014189491 @default.
• W2937230536 creator A5047642021 @default.
• W2937230536 creator A5068239144 @default.
• W2937230536 creator A5087201166 @default.
• W2937230536 creator A5087210747 @default.
• W2937230536 date "2019-02-28" @default.
• W2937230536 modified "2023-10-16" @default.
• W2937230536 title "Suppression of lymphocyte apoptosis in spleen by CXCL13 after porcine circovirus type 2 infection and regulatory mechanism of CXCL13 expression in pigs" @default.
• W2937230536 cites W1557965753 @default.
• W2937230536 cites W1586392520 @default.
• W2937230536 cites W1902528264 @default.
• W2937230536 cites W1964073714 @default.
• W2937230536 cites W1973201987 @default.
• W2937230536 cites W1976738924 @default.
• W2937230536 cites W1983170246 @default.
• W2937230536 cites W2002011103 @default.
• W2937230536 cites W2005701045 @default.
• W2937230536 cites W2009679533 @default.
• W2937230536 cites W2015650354 @default.
• W2937230536 cites W2040722908 @default.
• W2937230536 cites W2047964740 @default.
• W2937230536 cites W2052591083 @default.
• W2937230536 cites W2060605949 @default.
• W2937230536 cites W2075803881 @default.
• W2937230536 cites W2075966655 @default.
• W2937230536 cites W2088621466 @default.
• W2937230536 cites W2094051857 @default.
• W2937230536 cites W2096838352 @default.
• W2937230536 cites W2096981766 @default.
• W2937230536 cites W2100305481 @default.
• W2937230536 cites W2105362689 @default.
• W2937230536 cites W2111970919 @default.
• W2937230536 cites W2114123652 @default.
• W2937230536 cites W2120764395 @default.
• W2937230536 cites W2122874647 @default.
• W2937230536 cites W2124727440 @default.
• W2937230536 cites W2132134075 @default.
• W2937230536 cites W2133465414 @default.
• W2937230536 cites W2142237411 @default.
• W2937230536 cites W2142595644 @default.
• W2937230536 cites W2145995554 @default.
• W2937230536 cites W2146468359 @default.
• W2937230536 cites W2146555324 @default.
• W2937230536 cites W2147022432 @default.
• W2937230536 cites W2152239989 @default.
• W2937230536 cites W2170184451 @default.
• W2937230536 cites W2176091984 @default.
• W2937230536 cites W2367941313 @default.
• W2937230536 cites W2499001569 @default.
• W2937230536 cites W2611236229 @default.
• W2937230536 cites W2795755575 @default.
• W2937230536 cites W2799602498 @default.
• W2937230536 doi "https://doi.org/10.1186/s13567-019-0634-2" @default.
• W2937230536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6394056" @default.
• W2937230536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30819249" @default.
• W2937230536 hasPublicationYear "2019" @default.
• W2937230536 type Work @default.
• W2937230536 sameAs 2937230536 @default.
• W2937230536 citedByCount "14" @default.
• W2937230536 countsByYear W29372305362020 @default.
• W2937230536 countsByYear W29372305362021 @default.
• W2937230536 countsByYear W29372305362022 @default.
• W2937230536 countsByYear W29372305362023 @default.
• W2937230536 crossrefType "journal-article" @default.
• W2937230536 hasAuthorship W2937230536A5005616906 @default.
• W2937230536 hasAuthorship W2937230536A5007145458 @default.
• W2937230536 hasAuthorship W2937230536A5010165168 @default.
• W2937230536 hasAuthorship W2937230536A5014189491 @default.
• W2937230536 hasAuthorship W2937230536A5047642021 @default.
• W2937230536 hasAuthorship W2937230536A5068239144 @default.
• W2937230536 hasAuthorship W2937230536A5087201166 @default.
• W2937230536 hasAuthorship W2937230536A5087210747 @default.
• W2937230536 hasBestOaLocation W29372305361 @default.
• W2937230536 hasConcept C12823836 @default.
• W2937230536 hasConcept C13373296 @default.
• W2937230536 hasConcept C153911025 @default.
• W2937230536 hasConcept C159047783 @default.
• W2937230536 hasConcept C203014093 @default.
• W2937230536 hasConcept C2522874641 @default.
• W2937230536 hasConcept C2780931953 @default.
• W2937230536 hasConcept C2781045504 @default.
• W2937230536 hasConcept C75877943 @default.
• W2937230536 hasConcept C86803240 @default.
• W2937230536 hasConcept C8891405 @default.
• W2937230536 hasConceptScore W2937230536C12823836 @default.
• W2937230536 hasConceptScore W2937230536C13373296 @default.
• W2937230536 hasConceptScore W2937230536C153911025 @default.
• W2937230536 hasConceptScore W2937230536C159047783 @default.
• W2937230536 hasConceptScore W2937230536C203014093 @default.
• W2937230536 hasConceptScore W2937230536C2522874641 @default.
• W2937230536 hasConceptScore W2937230536C2780931953 @default.
• W2937230536 hasConceptScore W2937230536C2781045504 @default.
• W2937230536 hasConceptScore W2937230536C75877943 @default.
• W2937230536 hasConceptScore W2937230536C86803240 @default.
• W2937230536 hasConceptScore W2937230536C8891405 @default.

• next