FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937257532> ?p ?o ?g. }

• W2937257532 endingPage "8758" @default.
• W2937257532 startingPage "8745" @default.
• W2937257532 abstract "A single pool of multipotent retinal progenitor cells give rise to the diverse cell types within the mammalian retina. Such cellular diversity is due to precise control of various cellular processes like cell specification, proliferation, differentiation, and maturation. Circadian clock genes can control the expression of key regulators of cell cycle progression and therefore can synchronize the cell cycle state of a heterogeneous population of cells. Here we show that the protein encoded by the circadian clock gene brain and muscle arnt-like protein-1 (Bmal1) is expressed in the embryonic retina and is required to regulate the timing of cell cycle exit. Accordingly, loss of Bmal1 during retinal neurogenesis results in increased S-phase entry and delayed cell cycle exit. Disruption in cell cycle kinetics affects the timely generation of the appropriate neuronal population thus leading to an overall decrease in the number of retinal ganglion cells, amacrine cells, and an increase in the number of the late-born type II cone bipolar cells as well as the Müller glia. Additionally, the mislocalized Müller cells are observed in the photoreceptor layer in the Bmal1 conditional mutants. These changes affect the functional integrity of the visual circuitry as we report a significant delay in visual evoked potential implicit time in the retina-specific Bmal1 null animals. Our results demonstrate that Bmal1 is required to maintain the balance between the neural and glial cells in the embryonic retina by coordinating the timing of cell cycle entry and exit. Thus, Bmal1 plays an essential role during retinal neurogenesis affecting both development and function of the mature retina.-Sawant, O. B., Jidigam, V. K., Fuller, R. D., Zucaro, O. F., Kpegba, C., Yu, M., Peachey, N. S., Rao, S. The circadian clock gene Bmal1 is required to control the timing of retinal neurogenesis and lamination of Müller glia in the mouse retina." @default.
• W2937257532 created "2019-04-25" @default.
• W2937257532 creator A5003233728 @default.
• W2937257532 creator A5014192515 @default.
• W2937257532 creator A5024900490 @default.
• W2937257532 creator A5028963662 @default.
• W2937257532 creator A5045135468 @default.
• W2937257532 creator A5060284439 @default.
• W2937257532 creator A5069982614 @default.
• W2937257532 creator A5074534706 @default.
• W2937257532 date "2019-04-19" @default.
• W2937257532 modified "2023-10-01" @default.
• W2937257532 title "The circadian clock gene<i>Bmal1</i>is required to control the timing of retinal neurogenesis and lamination of Müller glia in the mouse retina" @default.
• W2937257532 cites W1895998181 @default.
• W2937257532 cites W1971030996 @default.
• W2937257532 cites W1972468954 @default.
• W2937257532 cites W1973652650 @default.
• W2937257532 cites W1978856373 @default.
• W2937257532 cites W1997179110 @default.
• W2937257532 cites W1998559978 @default.
• W2937257532 cites W2007665189 @default.
• W2937257532 cites W2013798878 @default.
• W2937257532 cites W2029207368 @default.
• W2937257532 cites W2032142769 @default.
• W2937257532 cites W2033585891 @default.
• W2937257532 cites W2036458630 @default.
• W2937257532 cites W2037390777 @default.
• W2937257532 cites W2042227355 @default.
• W2937257532 cites W2050137703 @default.
• W2937257532 cites W2050672796 @default.
• W2937257532 cites W2055065202 @default.
• W2937257532 cites W2065594360 @default.
• W2937257532 cites W2067091808 @default.
• W2937257532 cites W2067470032 @default.
• W2937257532 cites W2076131979 @default.
• W2937257532 cites W2076900594 @default.
• W2937257532 cites W2079229603 @default.
• W2937257532 cites W2082660627 @default.
• W2937257532 cites W2083991058 @default.
• W2937257532 cites W2088912866 @default.
• W2937257532 cites W2090841840 @default.
• W2937257532 cites W2102072876 @default.
• W2937257532 cites W2107434503 @default.
• W2937257532 cites W2116990217 @default.
• W2937257532 cites W2120447586 @default.
• W2937257532 cites W2129618668 @default.
• W2937257532 cites W2130496406 @default.
• W2937257532 cites W2133693969 @default.
• W2937257532 cites W2160214073 @default.
• W2937257532 cites W2163517157 @default.
• W2937257532 cites W2167058119 @default.
• W2937257532 cites W2167214853 @default.
• W2937257532 cites W2203087757 @default.
• W2937257532 cites W2303447433 @default.
• W2937257532 cites W2320661604 @default.
• W2937257532 cites W2341109211 @default.
• W2937257532 cites W2493972880 @default.
• W2937257532 cites W2567503091 @default.
• W2937257532 cites W2766436509 @default.
• W2937257532 cites W2799949277 @default.
• W2937257532 cites W2804474383 @default.
• W2937257532 cites W2811137840 @default.
• W2937257532 cites W2883800519 @default.
• W2937257532 cites W2903181644 @default.
• W2937257532 cites W2946389085 @default.
• W2937257532 cites W4241165462 @default.
• W2937257532 doi "https://doi.org/10.1096/fj.201801832rr" @default.
• W2937257532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6662963" @default.
• W2937257532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31002540" @default.
• W2937257532 hasPublicationYear "2019" @default.
• W2937257532 type Work @default.
• W2937257532 sameAs 2937257532 @default.
• W2937257532 citedByCount "20" @default.
• W2937257532 countsByYear W29372575322019 @default.
• W2937257532 countsByYear W29372575322020 @default.
• W2937257532 countsByYear W29372575322021 @default.
• W2937257532 countsByYear W29372575322022 @default.
• W2937257532 countsByYear W29372575322023 @default.
• W2937257532 crossrefType "journal-article" @default.
• W2937257532 hasAuthorship W2937257532A5003233728 @default.
• W2937257532 hasAuthorship W2937257532A5014192515 @default.
• W2937257532 hasAuthorship W2937257532A5024900490 @default.
• W2937257532 hasAuthorship W2937257532A5028963662 @default.
• W2937257532 hasAuthorship W2937257532A5045135468 @default.
• W2937257532 hasAuthorship W2937257532A5060284439 @default.
• W2937257532 hasAuthorship W2937257532A5069982614 @default.
• W2937257532 hasAuthorship W2937257532A5074534706 @default.
• W2937257532 hasBestOaLocation W29372575322 @default.
• W2937257532 hasConcept C104317684 @default.
• W2937257532 hasConcept C144024400 @default.
• W2937257532 hasConcept C145103041 @default.
• W2937257532 hasConcept C1491633281 @default.
• W2937257532 hasConcept C149923435 @default.
• W2937257532 hasConcept C169760540 @default.
• W2937257532 hasConcept C201750760 @default.
• W2937257532 hasConcept C2777093970 @default.
• W2937257532 hasConcept C2777102633 @default.
• W2937257532 hasConcept C28328180 @default.

• next