Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937265364> ?p ?o ?g. }
- W2937265364 endingPage "90" @default.
- W2937265364 startingPage "79" @default.
- W2937265364 abstract "The overall incidence of colon cancer (CC) is decreasing, but with increasing early-onset colon cancer (EOCC < 50 years old). Our recent study revealed unique overexpression of cartilage oligomeric matrix protein (COMP) in EOCC and its association with aggressiveness. The aim of this study was to assess CC biology, especially in the young, by evaluating the role of COMP in CC carcinogenesis and cancer progression, detecting COMP in serum and its association with disease stage.Cancer and matching noninvolved tissue blocks from 12 sporadic EOCC and late-onset colon cancer (LOCC) patients of 4 disease stages were obtained from pathology archives. Ribonucleic acid expression profiling of 770 cancer-related genes using nCounter platform was performed. The COMP levels from 16 EOCC and LOCC serum samples were measured by ELISA. Carcinoembryonic antigen levels from these 16 samples were taken at the time of diagnosis. Transwell assay was performed to elucidate the role of COMP in motility and metastases.Expression profiling revealed increased COMP levels in higher disease stage. There was 7-fold higher COMP expression (p ≤ 0.05) in stage III compare to stage I and its coexpression with GAS1, VEGFC, MAP3K8, SFRP1, and PRKACA. Higher COMP expression was seen in stage II compared with stage I (p = 0.07) and its coexpression withTLR2, IL8, RIN1, IRAK3, and CACNA2D2, and COMP was detectable in serum and showed significantly higher levels in EOCC compared with LOCC. Similar correlation was seen with CEA levels, but the difference was not significant. Transwell assay revealed significantly increased motility of HT-29 cells after treatment with recombinant COMP.These findings suggest different tumor biology between EOCC and LOCC. Cartilage oligomeric matrix protein plays a significant role in CC carcinogenesis and has potential as biomarker for CC, especially aggressive EOCC." @default.
- W2937265364 created "2019-04-25" @default.
- W2937265364 creator A5014606227 @default.
- W2937265364 creator A5025510544 @default.
- W2937265364 creator A5031912982 @default.
- W2937265364 creator A5038870352 @default.
- W2937265364 creator A5042741079 @default.
- W2937265364 creator A5057141823 @default.
- W2937265364 creator A5070640675 @default.
- W2937265364 creator A5074705508 @default.
- W2937265364 date "2019-07-01" @default.
- W2937265364 modified "2023-09-25" @default.
- W2937265364 title "Increasing Incidence of Colon Cancer in the Young: Assessing the Tumor Biology" @default.
- W2937265364 cites W1554656018 @default.
- W2937265364 cites W1582279834 @default.
- W2937265364 cites W1605960013 @default.
- W2937265364 cites W1995830102 @default.
- W2937265364 cites W1996860520 @default.
- W2937265364 cites W2005259839 @default.
- W2937265364 cites W2016774298 @default.
- W2937265364 cites W2048101653 @default.
- W2937265364 cites W2055270214 @default.
- W2937265364 cites W2057441785 @default.
- W2937265364 cites W2057583190 @default.
- W2937265364 cites W2059844441 @default.
- W2937265364 cites W2078874550 @default.
- W2937265364 cites W2085503849 @default.
- W2937265364 cites W2105772211 @default.
- W2937265364 cites W2147366336 @default.
- W2937265364 cites W2149504763 @default.
- W2937265364 cites W2160281016 @default.
- W2937265364 cites W2167546181 @default.
- W2937265364 cites W2169911608 @default.
- W2937265364 cites W2279715668 @default.
- W2937265364 cites W2284098333 @default.
- W2937265364 cites W2328577203 @default.
- W2937265364 cites W2345590567 @default.
- W2937265364 cites W2443966614 @default.
- W2937265364 cites W2592701528 @default.
- W2937265364 cites W2757770824 @default.
- W2937265364 cites W2760137314 @default.
- W2937265364 cites W2781525129 @default.
- W2937265364 cites W2791533314 @default.
- W2937265364 cites W2891314908 @default.
- W2937265364 doi "https://doi.org/10.1016/j.jamcollsurg.2019.03.022" @default.
- W2937265364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30995524" @default.
- W2937265364 hasPublicationYear "2019" @default.
- W2937265364 type Work @default.
- W2937265364 sameAs 2937265364 @default.
- W2937265364 citedByCount "12" @default.
- W2937265364 countsByYear W29372653642019 @default.
- W2937265364 countsByYear W29372653642021 @default.
- W2937265364 countsByYear W29372653642022 @default.
- W2937265364 countsByYear W29372653642023 @default.
- W2937265364 crossrefType "journal-article" @default.
- W2937265364 hasAuthorship W2937265364A5014606227 @default.
- W2937265364 hasAuthorship W2937265364A5025510544 @default.
- W2937265364 hasAuthorship W2937265364A5031912982 @default.
- W2937265364 hasAuthorship W2937265364A5038870352 @default.
- W2937265364 hasAuthorship W2937265364A5042741079 @default.
- W2937265364 hasAuthorship W2937265364A5057141823 @default.
- W2937265364 hasAuthorship W2937265364A5070640675 @default.
- W2937265364 hasAuthorship W2937265364A5074705508 @default.
- W2937265364 hasConcept C121608353 @default.
- W2937265364 hasConcept C126322002 @default.
- W2937265364 hasConcept C142724271 @default.
- W2937265364 hasConcept C143998085 @default.
- W2937265364 hasConcept C146357865 @default.
- W2937265364 hasConcept C151730666 @default.
- W2937265364 hasConcept C204787440 @default.
- W2937265364 hasConcept C2776164576 @default.
- W2937265364 hasConcept C2777387746 @default.
- W2937265364 hasConcept C2778232976 @default.
- W2937265364 hasConcept C502942594 @default.
- W2937265364 hasConcept C526805850 @default.
- W2937265364 hasConcept C555283112 @default.
- W2937265364 hasConcept C71924100 @default.
- W2937265364 hasConcept C86803240 @default.
- W2937265364 hasConceptScore W2937265364C121608353 @default.
- W2937265364 hasConceptScore W2937265364C126322002 @default.
- W2937265364 hasConceptScore W2937265364C142724271 @default.
- W2937265364 hasConceptScore W2937265364C143998085 @default.
- W2937265364 hasConceptScore W2937265364C146357865 @default.
- W2937265364 hasConceptScore W2937265364C151730666 @default.
- W2937265364 hasConceptScore W2937265364C204787440 @default.
- W2937265364 hasConceptScore W2937265364C2776164576 @default.
- W2937265364 hasConceptScore W2937265364C2777387746 @default.
- W2937265364 hasConceptScore W2937265364C2778232976 @default.
- W2937265364 hasConceptScore W2937265364C502942594 @default.
- W2937265364 hasConceptScore W2937265364C526805850 @default.
- W2937265364 hasConceptScore W2937265364C555283112 @default.
- W2937265364 hasConceptScore W2937265364C71924100 @default.
- W2937265364 hasConceptScore W2937265364C86803240 @default.
- W2937265364 hasFunder F4320310771 @default.
- W2937265364 hasIssue "1" @default.
- W2937265364 hasLocation W29372653641 @default.
- W2937265364 hasLocation W29372653642 @default.
- W2937265364 hasOpenAccess W2937265364 @default.