FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937331472> ?p ?o ?g. }

• W2937331472 endingPage "834" @default.
• W2937331472 startingPage "828" @default.
• W2937331472 abstract "Background: Minimal data exist related to neurodevelopment after in utero exposure to Efavirenz (EFV). We sought to compare neurodevelopmental outcomes in HIV-exposed/uninfected (HEU) children with in utero exposure to EFV-based triple antiretroviral treatment (ART) versus non-EFV-based ART, and to examine whether timing of initial EFV exposure is associated with neurodevelopment deficits. Methods: Women living with HIV who had received EFV-based ART during pregnancy and whose HEU newborn participated in a prior study were reconsented for their HEU toddler to undergo neurodevelopmental testing at 24 months old. We administered the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III), Developmental Milestones Checklist (DMC) and Profile of Social Emotional Development (PSED). We compared outcomes to previously-collected data from a cohort of 24-month-old HEU children with in utero exposure to non-EFV-based ART. Adjusted general linear models were used to compare mean outcomes. Results: Our analysis included 493 HEU children (126 EFV-exposed, 367 EFV-unexposed). Adjusted mean scores for the EFV-exposed group were worse than the EFV-unexposed group on BSID-III Receptive Language (adjusted means = 21.5 vs. 22.5, P = 0.05), DMC Locomotor (30.7 vs. 32.0, P < 0.01) and Fine Motor scales (17.8 vs. 19.2, P < 0.01); and PSED (11.7 vs. 9.9, P = 0.02); but better on the DMC Language scale (17.6 vs. 16.5, P = 0.01). Earlier (vs. later) EFV exposure was associated with worse scores on the BSID-III Receptive Language scale (20.7 vs. 22.2, P = 0.02). Conclusions: HEU children exposed in utero to EFV-based ART may be at higher risk for neurodevelopmental and social-emotional deficits than HEU children exposed to non-EFV-based ART." @default.
• W2937331472 created "2019-04-25" @default.
• W2937331472 creator A5023448326 @default.
• W2937331472 creator A5026379042 @default.
• W2937331472 creator A5030452461 @default.
• W2937331472 creator A5030501259 @default.
• W2937331472 creator A5032863083 @default.
• W2937331472 creator A5050589978 @default.
• W2937331472 creator A5053509467 @default.
• W2937331472 creator A5057590991 @default.
• W2937331472 creator A5062537464 @default.
• W2937331472 creator A5065275718 @default.
• W2937331472 creator A5077967172 @default.
• W2937331472 creator A5081089994 @default.
• W2937331472 creator A5091467152 @default.
• W2937331472 date "2019-08-01" @default.
• W2937331472 modified "2023-09-27" @default.
• W2937331472 title "In Utero Efavirenz Exposure and Neurodevelopmental Outcomes in HIV-exposed Uninfected Children in Botswana" @default.
• W2937331472 cites W1970617421 @default.
• W2937331472 cites W1995954588 @default.
• W2937331472 cites W1996214734 @default.
• W2937331472 cites W2008681391 @default.
• W2937331472 cites W2023245206 @default.
• W2937331472 cites W2040712012 @default.
• W2937331472 cites W2053512605 @default.
• W2937331472 cites W2054393681 @default.
• W2937331472 cites W2059527510 @default.
• W2937331472 cites W2065432904 @default.
• W2937331472 cites W2072505863 @default.
• W2937331472 cites W2089504584 @default.
• W2937331472 cites W2095445552 @default.
• W2937331472 cites W2096524996 @default.
• W2937331472 cites W2101932373 @default.
• W2937331472 cites W2112643175 @default.
• W2937331472 cites W2112677717 @default.
• W2937331472 cites W2116914456 @default.
• W2937331472 cites W2118451323 @default.
• W2937331472 cites W2122140164 @default.
• W2937331472 cites W2127018813 @default.
• W2937331472 cites W2144324254 @default.
• W2937331472 cites W2148399921 @default.
• W2937331472 cites W2149563075 @default.
• W2937331472 cites W2165674876 @default.
• W2937331472 cites W2168267011 @default.
• W2937331472 cites W2318326325 @default.
• W2937331472 cites W2508989832 @default.
• W2937331472 cites W2513882531 @default.
• W2937331472 cites W2548349844 @default.
• W2937331472 cites W2551560944 @default.
• W2937331472 cites W2596939656 @default.
• W2937331472 cites W2605130323 @default.
• W2937331472 cites W2755832866 @default.
• W2937331472 cites W2789425171 @default.
• W2937331472 cites W2793114601 @default.
• W2937331472 cites W2800987932 @default.
• W2937331472 cites W2801439144 @default.
• W2937331472 cites W2804719639 @default.
• W2937331472 cites W2810630855 @default.
• W2937331472 cites W2883284210 @default.
• W2937331472 cites W2884965680 @default.
• W2937331472 cites W2897366126 @default.
• W2937331472 cites W4253187683 @default.
• W2937331472 doi "https://doi.org/10.1097/inf.0000000000002332" @default.
• W2937331472 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6629483" @default.
• W2937331472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30985518" @default.
• W2937331472 hasPublicationYear "2019" @default.
• W2937331472 type Work @default.
• W2937331472 sameAs 2937331472 @default.
• W2937331472 citedByCount "28" @default.
• W2937331472 countsByYear W29373314722019 @default.
• W2937331472 countsByYear W29373314722020 @default.
• W2937331472 countsByYear W29373314722021 @default.
• W2937331472 countsByYear W29373314722022 @default.
• W2937331472 countsByYear W29373314722023 @default.
• W2937331472 crossrefType "journal-article" @default.
• W2937331472 hasAuthorship W2937331472A5023448326 @default.
• W2937331472 hasAuthorship W2937331472A5026379042 @default.
• W2937331472 hasAuthorship W2937331472A5030452461 @default.
• W2937331472 hasAuthorship W2937331472A5030501259 @default.
• W2937331472 hasAuthorship W2937331472A5032863083 @default.
• W2937331472 hasAuthorship W2937331472A5050589978 @default.
• W2937331472 hasAuthorship W2937331472A5053509467 @default.
• W2937331472 hasAuthorship W2937331472A5057590991 @default.
• W2937331472 hasAuthorship W2937331472A5062537464 @default.
• W2937331472 hasAuthorship W2937331472A5065275718 @default.
• W2937331472 hasAuthorship W2937331472A5077967172 @default.
• W2937331472 hasAuthorship W2937331472A5081089994 @default.
• W2937331472 hasAuthorship W2937331472A5091467152 @default.
• W2937331472 hasBestOaLocation W29373314722 @default.
• W2937331472 hasConcept C103728769 @default.
• W2937331472 hasConcept C118552586 @default.
• W2937331472 hasConcept C126322002 @default.
• W2937331472 hasConcept C138496976 @default.
• W2937331472 hasConcept C142462285 @default.
• W2937331472 hasConcept C15744967 @default.
• W2937331472 hasConcept C164953862 @default.
• W2937331472 hasConcept C169900460 @default.
• W2937331472 hasConcept C172680121 @default.

• next