FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937336345> ?p ?o ?g. }

• W2937336345 endingPage "873" @default.
• W2937336345 startingPage "862" @default.
• W2937336345 abstract "Extra-intestinal manifestations (EIM) are common in inflammatory bowel disease (IBD). One such EIM is sub-clinical pulmonary inflammation, which occurs in up to 50% of IBD patients. In animal models of colitis, pulmonary inflammation is driven by neutrophilic infiltrations, primarily in response to the systemic bacteraemia and increased bacterial load in the lungs. Platelet activating factor receptor (PAFR) plays a critical role in regulating pulmonary responses to infection in conditions, such as chronic obstructive pulmonary disease and asthma. We investigated the role of PAFR in pulmonary EIMs of IBD, using dextran sulfate sodium (DSS) and anti-CD40 murine models of colitis. Both models induced neutrophilic inflammation, with increased TNF and IL-1β levels, bacterial load and PAFR protein expression in mouse lungs. Antagonism of PAFR decreased lung neutrophilia, TNF, and IL-1β in an NLRP3 inflammasome-dependent manner. Lipopolysaccharide from phosphorylcholine (ChoP)-positive bacteria induced NLRP3 and caspase-1 proteins in human alveolar epithelial cells, however antagonism of PAFR prevented NLRP3 activation by ChoP. Amoxicillin reduced bacterial populations in the lungs and reduced NLRP3 inflammasome protein levels, but did not reduce PAFR. These data suggest a role for PAFR in microbial pattern recognition and NLRP3 inflammasome signaling in the lung." @default.
• W2937336345 created "2019-04-25" @default.
• W2937336345 creator A5010620272 @default.
• W2937336345 creator A5013045669 @default.
• W2937336345 creator A5018707164 @default.
• W2937336345 creator A5020598405 @default.
• W2937336345 creator A5023800164 @default.
• W2937336345 creator A5029245116 @default.
• W2937336345 creator A5043300180 @default.
• W2937336345 creator A5046419508 @default.
• W2937336345 creator A5054951172 @default.
• W2937336345 creator A5055421170 @default.
• W2937336345 creator A5061818786 @default.
• W2937336345 creator A5064708356 @default.
• W2937336345 creator A5067305437 @default.
• W2937336345 creator A5072697342 @default.
• W2937336345 creator A5076048446 @default.
• W2937336345 creator A5076487121 @default.
• W2937336345 creator A5090297779 @default.
• W2937336345 date "2019-07-01" @default.
• W2937336345 modified "2023-10-18" @default.
• W2937336345 title "Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome" @default.
• W2937336345 cites W1582241183 @default.
• W2937336345 cites W1631447675 @default.
• W2937336345 cites W1899491045 @default.
• W2937336345 cites W1970265625 @default.
• W2937336345 cites W1973530626 @default.
• W2937336345 cites W1975850098 @default.
• W2937336345 cites W1977289780 @default.
• W2937336345 cites W1984238182 @default.
• W2937336345 cites W1991718644 @default.
• W2937336345 cites W1992664495 @default.
• W2937336345 cites W2004327544 @default.
• W2937336345 cites W2009710456 @default.
• W2937336345 cites W2010629543 @default.
• W2937336345 cites W2010767372 @default.
• W2937336345 cites W2012549312 @default.
• W2937336345 cites W2018975142 @default.
• W2937336345 cites W2030193400 @default.
• W2937336345 cites W2052643656 @default.
• W2937336345 cites W2056425530 @default.
• W2937336345 cites W2057759034 @default.
• W2937336345 cites W2065403173 @default.
• W2937336345 cites W2067773009 @default.
• W2937336345 cites W2069019128 @default.
• W2937336345 cites W2091410303 @default.
• W2937336345 cites W2095589751 @default.
• W2937336345 cites W2127314810 @default.
• W2937336345 cites W2133012172 @default.
• W2937336345 cites W2134373232 @default.
• W2937336345 cites W2140489687 @default.
• W2937336345 cites W2140731876 @default.
• W2937336345 cites W2155563269 @default.
• W2937336345 cites W2157721156 @default.
• W2937336345 cites W2158807953 @default.
• W2937336345 cites W2165107045 @default.
• W2937336345 cites W2165655699 @default.
• W2937336345 cites W2167264906 @default.
• W2937336345 cites W2169476570 @default.
• W2937336345 cites W2172243307 @default.
• W2937336345 cites W2194525259 @default.
• W2937336345 cites W2439973029 @default.
• W2937336345 cites W2515478966 @default.
• W2937336345 cites W2534843689 @default.
• W2937336345 cites W2580170021 @default.
• W2937336345 cites W2581186479 @default.
• W2937336345 cites W2584140532 @default.
• W2937336345 cites W2724809801 @default.
• W2937336345 cites W2735696384 @default.
• W2937336345 cites W2747666769 @default.
• W2937336345 cites W2751285788 @default.
• W2937336345 cites W2800513588 @default.
• W2937336345 cites W2883733437 @default.
• W2937336345 cites W4238394506 @default.
• W2937336345 doi "https://doi.org/10.1038/s41385-019-0163-3" @default.
• W2937336345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30976089" @default.
• W2937336345 hasPublicationYear "2019" @default.
• W2937336345 type Work @default.
• W2937336345 sameAs 2937336345 @default.
• W2937336345 citedByCount "40" @default.
• W2937336345 countsByYear W29373363452019 @default.
• W2937336345 countsByYear W29373363452020 @default.
• W2937336345 countsByYear W29373363452021 @default.
• W2937336345 countsByYear W29373363452022 @default.
• W2937336345 countsByYear W29373363452023 @default.
• W2937336345 crossrefType "journal-article" @default.
• W2937336345 hasAuthorship W2937336345A5010620272 @default.
• W2937336345 hasAuthorship W2937336345A5013045669 @default.
• W2937336345 hasAuthorship W2937336345A5018707164 @default.
• W2937336345 hasAuthorship W2937336345A5020598405 @default.
• W2937336345 hasAuthorship W2937336345A5023800164 @default.
• W2937336345 hasAuthorship W2937336345A5029245116 @default.
• W2937336345 hasAuthorship W2937336345A5043300180 @default.
• W2937336345 hasAuthorship W2937336345A5046419508 @default.
• W2937336345 hasAuthorship W2937336345A5054951172 @default.
• W2937336345 hasAuthorship W2937336345A5055421170 @default.
• W2937336345 hasAuthorship W2937336345A5061818786 @default.
• W2937336345 hasAuthorship W2937336345A5064708356 @default.

• next