Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937337637> ?p ?o ?g. }
- W2937337637 endingPage "334" @default.
- W2937337637 startingPage "334" @default.
- W2937337637 abstract "Prions are infectious β-sheet-rich protein aggregates composed of misfolded prion protein (PrPSc) that do not possess coding nucleic acid. Prions replicate by recruiting and converting normal cellular PrPC into infectious isoforms. In the same host species, prion strains target distinct brain regions and cause different disease phenotypes. Prion strains are associated with biophysically distinct PrPSc conformers, suggesting that strain properties are enciphered within alternative PrPSc quaternary structures. So far it is unknown how prion strains target specific cells and initiate productive infections. Deeper mechanistic insight into the prion life cycle came from cell lines permissive to a range of different prion strains. Still, it is unknown why certain cell lines are refractory to infection by one strain but permissive to another. While pharmacologic and genetic manipulations revealed subcellular compartments involved in prion replication, little is known about strain-specific requirements for endocytic trafficking pathways. This review summarizes our knowledge on how prions replicate within their target cells and on strain-specific differences in prion cell biology." @default.
- W2937337637 created "2019-04-25" @default.
- W2937337637 creator A5060703246 @default.
- W2937337637 date "2019-04-09" @default.
- W2937337637 modified "2023-09-24" @default.
- W2937337637 title "All the Same? The Secret Life of Prion Strains within Their Target Cells" @default.
- W2937337637 cites W1486696576 @default.
- W2937337637 cites W1486755788 @default.
- W2937337637 cites W1492038278 @default.
- W2937337637 cites W1494304190 @default.
- W2937337637 cites W1501494207 @default.
- W2937337637 cites W1533604120 @default.
- W2937337637 cites W1559460715 @default.
- W2937337637 cites W1567267284 @default.
- W2937337637 cites W1590689549 @default.
- W2937337637 cites W1601881612 @default.
- W2937337637 cites W1938969372 @default.
- W2937337637 cites W1945261349 @default.
- W2937337637 cites W1957113787 @default.
- W2937337637 cites W1968774879 @default.
- W2937337637 cites W1969302990 @default.
- W2937337637 cites W1971471116 @default.
- W2937337637 cites W1972062240 @default.
- W2937337637 cites W1972862320 @default.
- W2937337637 cites W1973510262 @default.
- W2937337637 cites W1976442454 @default.
- W2937337637 cites W1976981405 @default.
- W2937337637 cites W1980269923 @default.
- W2937337637 cites W1981738652 @default.
- W2937337637 cites W1981747825 @default.
- W2937337637 cites W1982030993 @default.
- W2937337637 cites W1990104994 @default.
- W2937337637 cites W1992675300 @default.
- W2937337637 cites W1994626237 @default.
- W2937337637 cites W1994668150 @default.
- W2937337637 cites W1996648035 @default.
- W2937337637 cites W1997259637 @default.
- W2937337637 cites W1997757326 @default.
- W2937337637 cites W1997973599 @default.
- W2937337637 cites W2005373419 @default.
- W2937337637 cites W2019007228 @default.
- W2937337637 cites W2022607259 @default.
- W2937337637 cites W2022654779 @default.
- W2937337637 cites W2024954984 @default.
- W2937337637 cites W2024965367 @default.
- W2937337637 cites W2028622306 @default.
- W2937337637 cites W2032604948 @default.
- W2937337637 cites W2032706649 @default.
- W2937337637 cites W2034359525 @default.
- W2937337637 cites W2041250499 @default.
- W2937337637 cites W2043656720 @default.
- W2937337637 cites W2043923768 @default.
- W2937337637 cites W2043943109 @default.
- W2937337637 cites W2044657703 @default.
- W2937337637 cites W2044666532 @default.
- W2937337637 cites W2044889035 @default.
- W2937337637 cites W2044966532 @default.
- W2937337637 cites W2046487370 @default.
- W2937337637 cites W2048003269 @default.
- W2937337637 cites W2051391548 @default.
- W2937337637 cites W2052976709 @default.
- W2937337637 cites W2053846184 @default.
- W2937337637 cites W2058994860 @default.
- W2937337637 cites W2060193071 @default.
- W2937337637 cites W2061266771 @default.
- W2937337637 cites W2063880942 @default.
- W2937337637 cites W2067540111 @default.
- W2937337637 cites W2071441527 @default.
- W2937337637 cites W2071609717 @default.
- W2937337637 cites W2072413573 @default.
- W2937337637 cites W2075606263 @default.
- W2937337637 cites W2076532781 @default.
- W2937337637 cites W2076932736 @default.
- W2937337637 cites W2077188678 @default.
- W2937337637 cites W2079701803 @default.
- W2937337637 cites W2081852339 @default.
- W2937337637 cites W2082011949 @default.
- W2937337637 cites W2082672533 @default.
- W2937337637 cites W2082825744 @default.
- W2937337637 cites W2089507595 @default.
- W2937337637 cites W2090733594 @default.
- W2937337637 cites W2091441082 @default.
- W2937337637 cites W2091849161 @default.
- W2937337637 cites W2092014857 @default.
- W2937337637 cites W2094881767 @default.
- W2937337637 cites W2095830494 @default.
- W2937337637 cites W2100615932 @default.
- W2937337637 cites W2104887455 @default.
- W2937337637 cites W2106235316 @default.
- W2937337637 cites W2106769886 @default.
- W2937337637 cites W2106963470 @default.
- W2937337637 cites W2107784996 @default.
- W2937337637 cites W2108175824 @default.
- W2937337637 cites W2108826380 @default.
- W2937337637 cites W2109691647 @default.
- W2937337637 cites W2118966800 @default.
- W2937337637 cites W2121776150 @default.
- W2937337637 cites W2122084338 @default.