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- W2937349051 abstract "Intermediate filaments (IFs) represent a major cytoskeletal network contributing to force transmission, cell shape and structure, adhesion and motility, subcellular scaffolding and tissue resilience, thereby modulating a range of cellular activities. Life-threatening disorders associated with IF mutations have pushed investigations to study IFs of mammalian cells in culture and in vivo. Keratin and Lamin related disorders, Desmin-related myopathy, Muscular Dystrophies, Alexander disease are just examples of pathologies related to IFs. Synemin, a type IV IF has become a target for research since its AKAP role in the heart was reported. Here we summarize our results with Synemin “knock-out” mice showing that Synemin plays a significant role in skeletal and cardiac muscle, leading to a mild skeletal myopathy and a mixed cardiomyopathy. We also report an important role of Synemin, with the absence of Synemin leading to osteopenia." @default.
- W2937349051 created "2019-04-25" @default.
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- W2937349051 date "2019-01-01" @default.
- W2937349051 modified "2023-09-23" @default.
- W2937349051 title "The mechanical role of a cytoskeletal protein, Synemin, in bone, heart and skeletal muscle" @default.
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- W2937349051 doi "https://doi.org/10.1063/1.5095923" @default.
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