Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937351490> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2937351490 endingPage "46" @default.
- W2937351490 startingPage "38" @default.
- W2937351490 abstract "Seventeen patients with active rheumatoid arthritis (RA) (group I) and fifteen patients with inactive RA (group II), in addition to ten healthy control subjects were included in the present study. All patients were evaluated clinically and biochemically according to the American College of Rheumatology (ACR) core set measures, and a comparison was set between both groups of patients. Serum levels of interleukin–12 (IL–12) and tumour necrosis factor– (TNF– ) were measured using enzyme linked immunosorbent assay (ELISA) in all patients and control subjects. It was found that there was no significant difference in age, sex, disease duration, degree of disability or physician's and patient's global assessments between both groups of patients (P>0.05), but patients with active RA had significantly higher tender joint score, swollen joint score, visual analogue pain scale, erythrocyte sedimentation rate and C– reactive protein compared to patients with inactive RA (P<0.05). Detectable levels of IL–12 in serum were found in 13 out of 17 (76.5%) active RA patients, 6 out of 15 (40%) inactive RA patients and 1 out of 10 (10%) healthy controls. TNF– was also detected in the serum of 12 out of 17 (70.6%) active RA patients, 7 out of 15 (46.7%) inactive RA patients and 1 out of 10 (10%) healthy controls, with significantly higher detectability and significantly higher mean serum levels of IL–12 and TNF– in patients with active RA compared to patients with inactive RA and healthy controls (P<0.05). However, patients with inactive RA had significantly higher detectability and significantly higher serum levels of IL–12 and TNF– compared to the healthy controls (P<0.05) which may reflect the role of IL–12 and TNF– in the pathogenesis of RA. Serum levels of IL–12 correlated positively with TNF– levels in serum in case of active RA patients (r=0.493) and inactive RA patients (r=0.474). It was concluded that significantly elevated serum levels of IL–12 and TNF– may be associated with clinical and laboratory markers of activity of RA; and measurement of serum IL–12 and TNF– levels could be used for assessment of RA activity. IL–12 and TNF– may play an important role in the pathogenesis and inflammatory activity of RA." @default.
- W2937351490 created "2019-04-25" @default.
- W2937351490 creator A5046188696 @default.
- W2937351490 creator A5054575118 @default.
- W2937351490 creator A5087449879 @default.
- W2937351490 date "2003-04-01" @default.
- W2937351490 modified "2023-09-28" @default.
- W2937351490 title "Serum Levels Of Interleukin–12 And Tumour Necrosis Factor– In Patients With Active And Inactive Rheumatoid Arthritis" @default.
- W2937351490 doi "https://doi.org/10.12816/ejhm.2003.18243" @default.
- W2937351490 hasPublicationYear "2003" @default.
- W2937351490 type Work @default.
- W2937351490 sameAs 2937351490 @default.
- W2937351490 citedByCount "0" @default.
- W2937351490 crossrefType "journal-article" @default.
- W2937351490 hasAuthorship W2937351490A5046188696 @default.
- W2937351490 hasAuthorship W2937351490A5054575118 @default.
- W2937351490 hasAuthorship W2937351490A5087449879 @default.
- W2937351490 hasConcept C126322002 @default.
- W2937351490 hasConcept C17991360 @default.
- W2937351490 hasConcept C198451711 @default.
- W2937351490 hasConcept C203014093 @default.
- W2937351490 hasConcept C2776232647 @default.
- W2937351490 hasConcept C2777077863 @default.
- W2937351490 hasConcept C2777575956 @default.
- W2937351490 hasConcept C2778143017 @default.
- W2937351490 hasConcept C71924100 @default.
- W2937351490 hasConcept C90924648 @default.
- W2937351490 hasConceptScore W2937351490C126322002 @default.
- W2937351490 hasConceptScore W2937351490C17991360 @default.
- W2937351490 hasConceptScore W2937351490C198451711 @default.
- W2937351490 hasConceptScore W2937351490C203014093 @default.
- W2937351490 hasConceptScore W2937351490C2776232647 @default.
- W2937351490 hasConceptScore W2937351490C2777077863 @default.
- W2937351490 hasConceptScore W2937351490C2777575956 @default.
- W2937351490 hasConceptScore W2937351490C2778143017 @default.
- W2937351490 hasConceptScore W2937351490C71924100 @default.
- W2937351490 hasConceptScore W2937351490C90924648 @default.
- W2937351490 hasIssue "1" @default.
- W2937351490 hasLocation W29373514901 @default.
- W2937351490 hasOpenAccess W2937351490 @default.
- W2937351490 hasPrimaryLocation W29373514901 @default.
- W2937351490 hasRelatedWork W116566418 @default.
- W2937351490 hasRelatedWork W1866259979 @default.
- W2937351490 hasRelatedWork W2079995781 @default.
- W2937351490 hasRelatedWork W2169051031 @default.
- W2937351490 hasRelatedWork W2324778399 @default.
- W2937351490 hasRelatedWork W2332708362 @default.
- W2937351490 hasRelatedWork W2348106302 @default.
- W2937351490 hasRelatedWork W2349933377 @default.
- W2937351490 hasRelatedWork W2351266087 @default.
- W2937351490 hasRelatedWork W2384014168 @default.
- W2937351490 hasRelatedWork W2397724518 @default.
- W2937351490 hasRelatedWork W2403249576 @default.
- W2937351490 hasRelatedWork W2404145334 @default.
- W2937351490 hasRelatedWork W2594105419 @default.
- W2937351490 hasRelatedWork W2741232042 @default.
- W2937351490 hasRelatedWork W2744883273 @default.
- W2937351490 hasRelatedWork W2775256853 @default.
- W2937351490 hasRelatedWork W2893414475 @default.
- W2937351490 hasRelatedWork W3024435566 @default.
- W2937351490 hasRelatedWork W3093447585 @default.
- W2937351490 hasVolume "12" @default.
- W2937351490 isParatext "false" @default.
- W2937351490 isRetracted "false" @default.
- W2937351490 magId "2937351490" @default.
- W2937351490 workType "article" @default.