Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937356813> ?p ?o ?g. }
- W2937356813 abstract "Abstract Microglia are the main immune cells in the brain with emerging roles in brain homeostasis and neurological diseases, while mechanisms underlying microglia-neuron communication remain elusive. Here, we identify a novel site of interaction between neuronal cell bodies and microglial processes in mouse and human brain. Somatic microglia-neuron junctions possess specialized nanoarchitecture optimized for purinergic signaling. Activity of neuronal mitochondria is linked with microglial junction formation, which is rapidly induced in response to neuronal activation and blocked by inhibition of P2Y12-receptors (P2Y12R). Brain injury-induced changes at somatic junctions trigger P2Y12R-dependent microglial neuroprotection, regulating neuronal calcium load and functional connectivity. Collectively, our results suggest that microglial processes at these junctions are in ideal position to monitor and protect neuronal functions in both the healthy and injured brain. One-sentence summary Neuronal cell bodies possess specialized, pre-formed sites, through which microglia monitor their status and exert neuroprotection." @default.
- W2937356813 created "2019-04-25" @default.
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- W2937356813 date "2019-04-13" @default.
- W2937356813 modified "2023-10-16" @default.
- W2937356813 title "Microglia monitor and protect neuronal function via specialized somatic purinergic junctions" @default.
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