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• W2937367049 abstract "The HIV type-1 nonnucleoside reverse transcriptase inhibitor, efavirenz, is widely used to treat HIV type-1 infection. Efavirenz is predominantly metabolized into inactive metabolites by cytochrome P450 (CYP)2B6, and patients with certain CYP2B6 genetic variants may be at increased risk for adverse effects, particularly central nervous system toxicity and treatment discontinuation. We summarize the evidence from the literature and provide therapeutic recommendations for efavirenz prescribing based on CYP2B6 genotypes." @default.
• W2937367049 created "2019-04-25" @default.
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• W2937367049 date "2019-07-05" @default.
• W2937367049 modified "2023-10-16" @default.
• W2937367049 title "Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for<i>CYP2B6</i>and Efavirenz‐Containing Antiretroviral Therapy" @default.
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• W2937367049 doi "https://doi.org/10.1002/cpt.1477" @default.
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