Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937408031> ?p ?o ?g. }
- W2937408031 endingPage "354" @default.
- W2937408031 startingPage "321" @default.
- W2937408031 abstract "Abstract Testosterone (T) is the principal androgen hormone, which serves as a precursor for formation of 5α-dihydrotestosterone (5α-DHT) or aromatization to estradiol (E2), each with important diverse physiological functions. T deficiency (TD; also referred to as hypogonadism), irrespective of its etiology (primary, secondary, or functional hypogonadism) has deleterious effects on men’s health and negatively impacts glycol-metabolic and cardio-metabolic functions, body composition, sexual function, and bone mineral density. Although TD is thought to increase with age and older men are at higher risk of TD, a considerable number of younger men are also afflicted with TD due to various causes. In addition, if remained untreated, TD contributes to anemia, reduces the quality of life, and increases mortality. This chapter summarizes the benefits of testosterone therapy and highlights the therapeutic and clinical value of this intervention in men with hypogonadism. Numerous studies, including recent clinical trials funded by NIH, provide strong evidence that T therapy is associated with a significant health benefit with regards to bone mineral density (BMD), anemia, sexual function, glycol-metabolic and cardio-metabolic functions, as well as improvements in body composition, mood, and quality of life. Outcomes in many of these studies also indicate that T therapy in the physiological range in hypogonadal men is a safe and effective therapeutic modality improving overall health and quality of life. However, such positive outcomes of T therapy on men’s health must be viewed with caution since long-term risks, if exist, have yet to be identified." @default.
- W2937408031 created "2019-04-25" @default.
- W2937408031 creator A5009310546 @default.
- W2937408031 creator A5069888995 @default.
- W2937408031 date "2019-01-01" @default.
- W2937408031 modified "2023-09-27" @default.
- W2937408031 title "Benefits and Risks of Testosterone Therapy in Men With Testosterone Deficiency" @default.
- W2937408031 cites W1486913153 @default.
- W2937408031 cites W1493360589 @default.
- W2937408031 cites W149772265 @default.
- W2937408031 cites W1503864876 @default.
- W2937408031 cites W1513674708 @default.
- W2937408031 cites W1524577273 @default.
- W2937408031 cites W1567426206 @default.
- W2937408031 cites W1569288525 @default.
- W2937408031 cites W1581939760 @default.
- W2937408031 cites W1582959126 @default.
- W2937408031 cites W1590654957 @default.
- W2937408031 cites W1614492335 @default.
- W2937408031 cites W1629389488 @default.
- W2937408031 cites W1667402504 @default.
- W2937408031 cites W1703838523 @default.
- W2937408031 cites W1718442556 @default.
- W2937408031 cites W1753661430 @default.
- W2937408031 cites W176571599 @default.
- W2937408031 cites W1818039308 @default.
- W2937408031 cites W1818591415 @default.
- W2937408031 cites W1835830037 @default.
- W2937408031 cites W1884246004 @default.
- W2937408031 cites W1905464153 @default.
- W2937408031 cites W1910196831 @default.
- W2937408031 cites W1917696566 @default.
- W2937408031 cites W1918870829 @default.
- W2937408031 cites W1929501887 @default.
- W2937408031 cites W1943633560 @default.
- W2937408031 cites W1953400201 @default.
- W2937408031 cites W1959554618 @default.
- W2937408031 cites W1964632278 @default.
- W2937408031 cites W1965002285 @default.
- W2937408031 cites W1965723331 @default.
- W2937408031 cites W1965767786 @default.
- W2937408031 cites W1966036915 @default.
- W2937408031 cites W1966998141 @default.
- W2937408031 cites W1967009009 @default.
- W2937408031 cites W1967470906 @default.
- W2937408031 cites W1968747744 @default.
- W2937408031 cites W1969325270 @default.
- W2937408031 cites W1969521125 @default.
- W2937408031 cites W1972668697 @default.
- W2937408031 cites W1975633687 @default.
- W2937408031 cites W1977417329 @default.
- W2937408031 cites W1980217767 @default.
- W2937408031 cites W1983146727 @default.
- W2937408031 cites W1983690581 @default.
- W2937408031 cites W1984609970 @default.
- W2937408031 cites W1985364719 @default.
- W2937408031 cites W1985592735 @default.
- W2937408031 cites W1985899289 @default.
- W2937408031 cites W1986110768 @default.
- W2937408031 cites W1987687635 @default.
- W2937408031 cites W1987977957 @default.
- W2937408031 cites W1988078426 @default.
- W2937408031 cites W1988429012 @default.
- W2937408031 cites W1988683927 @default.
- W2937408031 cites W1989458934 @default.
- W2937408031 cites W1989743943 @default.
- W2937408031 cites W1991600755 @default.
- W2937408031 cites W1992811319 @default.
- W2937408031 cites W1993128219 @default.
- W2937408031 cites W1993415936 @default.
- W2937408031 cites W1995070361 @default.
- W2937408031 cites W1997825003 @default.
- W2937408031 cites W1998654117 @default.
- W2937408031 cites W1998794654 @default.
- W2937408031 cites W1999059326 @default.
- W2937408031 cites W2000266060 @default.
- W2937408031 cites W2000380456 @default.
- W2937408031 cites W2001118572 @default.
- W2937408031 cites W2001610421 @default.
- W2937408031 cites W2001741671 @default.
- W2937408031 cites W2002514892 @default.
- W2937408031 cites W2007422108 @default.
- W2937408031 cites W2007563685 @default.
- W2937408031 cites W2007908928 @default.
- W2937408031 cites W2007948385 @default.
- W2937408031 cites W2008415699 @default.
- W2937408031 cites W2009168838 @default.
- W2937408031 cites W2009351118 @default.
- W2937408031 cites W2009729812 @default.
- W2937408031 cites W2009810419 @default.
- W2937408031 cites W2010023375 @default.
- W2937408031 cites W2013481831 @default.
- W2937408031 cites W2013559131 @default.
- W2937408031 cites W2016747974 @default.
- W2937408031 cites W2016779560 @default.
- W2937408031 cites W2020438145 @default.
- W2937408031 cites W2021070586 @default.
- W2937408031 cites W2021888483 @default.