FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937435780> ?p ?o ?g. }

• W2937435780 endingPage "553" @default.
• W2937435780 startingPage "545" @default.
• W2937435780 abstract "Ivabradine hydrochloride (IVA-HCl) (systematic name: {[3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl]methyl}[3-(7,8-dimethoxy-2-oxo-2,3,4,5-tetrahydro-1 H -3-benzazepin-3-yl)propyl]methylazanium), is a novel medication used for the symptomatic management of stable angina pectoris. In many recent patents, it has been claimed to exist in a very large number of polymorphic, hydrated and solvated phases, although no detailed analysis of the structural features of these forms has been published to date. Here, we have successfully crystallized the tetrahydrate form of IVA-HCl (form β), C 27 H 37 N 2 O 5 + ·Cl − ·4H 2 O, and elucidated its structure for the first time. Simultaneously, a new crystal form of IVA-HCl, i.e. the hemihydrate (form II), C 27 H 37 N 2 O 5 + ·Cl − ·0.5H 2 O, was discovered. Its crystal structure was also accurately determined and compared to that of the tetrahydrate form. While the tetrahydrate form of IVA-HCl crystallized in the orthorhombic space group P 2 1 2 1 2 1 , the new form (hemihydrate) was solved in the monoclinic space group P 2 1 . Detailed conformational and packing comparisons between the two forms have allowed us to understand the role of water in the crystal assembly of this hydrochloride salt. The stabilities of the two forms were compared theoretically by calculating the binding energy of the water in the crystal lattice using differential scanning calorimetry (DSC). The stability experiments show that the tetrahydrate is stable under high-humidity conditions, while the hemihydrate is stable under high-temperature conditions." @default.
• W2937435780 created "2019-04-25" @default.
• W2937435780 creator A5021698894 @default.
• W2937435780 creator A5031361021 @default.
• W2937435780 creator A5051365005 @default.
• W2937435780 creator A5061230904 @default.
• W2937435780 creator A5075827205 @default.
• W2937435780 creator A5075853000 @default.
• W2937435780 date "2019-04-11" @default.
• W2937435780 modified "2023-09-27" @default.
• W2937435780 title "Crystal structures and properties of two hydrated conglomerate forms of the heart-rate-lowering agent ivabradine hydrochloride" @default.
• W2937435780 cites W1512902225 @default.
• W2937435780 cites W1905183855 @default.
• W2937435780 cites W1969360633 @default.
• W2937435780 cites W1978633893 @default.
• W2937435780 cites W1990170643 @default.
• W2937435780 cites W1998287126 @default.
• W2937435780 cites W1998920258 @default.
• W2937435780 cites W2012488984 @default.
• W2937435780 cites W2015326221 @default.
• W2937435780 cites W2021720051 @default.
• W2937435780 cites W2048703047 @default.
• W2937435780 cites W2049714190 @default.
• W2937435780 cites W2059205366 @default.
• W2937435780 cites W2066351739 @default.
• W2937435780 cites W2079508636 @default.
• W2937435780 cites W2085110791 @default.
• W2937435780 cites W2091654157 @default.
• W2937435780 cites W2111325726 @default.
• W2937435780 cites W2132454074 @default.
• W2937435780 cites W2140174761 @default.
• W2937435780 cites W2166032823 @default.
• W2937435780 cites W2319902168 @default.
• W2937435780 cites W2569747430 @default.
• W2937435780 doi "https://doi.org/10.1107/s2053229619004819" @default.
• W2937435780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31062711" @default.
• W2937435780 hasPublicationYear "2019" @default.
• W2937435780 type Work @default.
• W2937435780 sameAs 2937435780 @default.
• W2937435780 citedByCount "2" @default.
• W2937435780 countsByYear W29374357802020 @default.
• W2937435780 countsByYear W29374357802021 @default.
• W2937435780 crossrefType "journal-article" @default.
• W2937435780 hasAuthorship W2937435780A5021698894 @default.
• W2937435780 hasAuthorship W2937435780A5031361021 @default.
• W2937435780 hasAuthorship W2937435780A5051365005 @default.
• W2937435780 hasAuthorship W2937435780A5061230904 @default.
• W2937435780 hasAuthorship W2937435780A5075827205 @default.
• W2937435780 hasAuthorship W2937435780A5075853000 @default.
• W2937435780 hasConcept C115624301 @default.
• W2937435780 hasConcept C121332964 @default.
• W2937435780 hasConcept C124392266 @default.
• W2937435780 hasConcept C131468747 @default.
• W2937435780 hasConcept C178790620 @default.
• W2937435780 hasConcept C185592680 @default.
• W2937435780 hasConcept C199360897 @default.
• W2937435780 hasConcept C2776460385 @default.
• W2937435780 hasConcept C2781060337 @default.
• W2937435780 hasConcept C2781285689 @default.
• W2937435780 hasConcept C37243968 @default.
• W2937435780 hasConcept C39519442 @default.
• W2937435780 hasConcept C41008148 @default.
• W2937435780 hasConcept C61276311 @default.
• W2937435780 hasConcept C8010536 @default.
• W2937435780 hasConcept C97355855 @default.
• W2937435780 hasConceptScore W2937435780C115624301 @default.
• W2937435780 hasConceptScore W2937435780C121332964 @default.
• W2937435780 hasConceptScore W2937435780C124392266 @default.
• W2937435780 hasConceptScore W2937435780C131468747 @default.
• W2937435780 hasConceptScore W2937435780C178790620 @default.
• W2937435780 hasConceptScore W2937435780C185592680 @default.
• W2937435780 hasConceptScore W2937435780C199360897 @default.
• W2937435780 hasConceptScore W2937435780C2776460385 @default.
• W2937435780 hasConceptScore W2937435780C2781060337 @default.
• W2937435780 hasConceptScore W2937435780C2781285689 @default.
• W2937435780 hasConceptScore W2937435780C37243968 @default.
• W2937435780 hasConceptScore W2937435780C39519442 @default.
• W2937435780 hasConceptScore W2937435780C41008148 @default.
• W2937435780 hasConceptScore W2937435780C61276311 @default.
• W2937435780 hasConceptScore W2937435780C8010536 @default.
• W2937435780 hasConceptScore W2937435780C97355855 @default.
• W2937435780 hasIssue "5" @default.
• W2937435780 hasLocation W29374357801 @default.
• W2937435780 hasLocation W29374357802 @default.
• W2937435780 hasOpenAccess W2937435780 @default.
• W2937435780 hasPrimaryLocation W29374357801 @default.
• W2937435780 hasRelatedWork W1967976872 @default.
• W2937435780 hasRelatedWork W2040335679 @default.
• W2937435780 hasRelatedWork W2050949380 @default.
• W2937435780 hasRelatedWork W2059961116 @default.
• W2937435780 hasRelatedWork W2093692263 @default.
• W2937435780 hasRelatedWork W2110991995 @default.
• W2937435780 hasRelatedWork W2365429784 @default.
• W2937435780 hasRelatedWork W2462612165 @default.
• W2937435780 hasRelatedWork W2902603126 @default.
• W2937435780 hasRelatedWork W3005286928 @default.
• W2937435780 hasVolume "75" @default.
• W2937435780 isParatext "false" @default.

• next