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- W2937444227 abstract "Unique properties of the biological network are their own ability to convert different types and quantity of biochemical information into dynamically different responses of the same molecules, which results in distinct cell fate decisions. Signaling pathways and the cell cycle machinery follow common principles regulating such decision-making by integrating all-or-none and graded molecular activities. They also share genes encoding and decoding quantitative information between the two systems. For instance, early-response genes decipher upstream signal dynamics and function as the network hub at the restriction point and regulate irreversible progression into the S phase of the cell cycle. This review provides an overview of signal-dependent transcription and cell cycle regulation and presents a mathematical model integrating the two networks to better understand the mechanisms underlying cellular decision-making." @default.
- W2937444227 created "2019-04-25" @default.
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- W2937444227 date "2019-06-01" @default.
- W2937444227 modified "2023-09-27" @default.
- W2937444227 title "Signal-dependent regulation of early-response genes and cell cycle: a quantitative view" @default.
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- W2937444227 doi "https://doi.org/10.1016/j.coisb.2019.04.003" @default.
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