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- W2937591719 abstract "Increasing attention paid to the main family of peroxisome proliferator activated receptors - PPARs is generated, on one hand by the multiple functions of its members in numerous metabolically active tissues, and on the other hand by the therapeutic benefits expresed by some specific ligands that are used in certain metabolic diseases treatment plan. PPARα stimulates the β-oxidative degradation of fatty acids and controls plasma lipid transport through the mediated action upon the triglycerides and fatty acids metabolism and by modulation of biosynthesis and catabolism of bile acids in the liver. PPARγ promotes adipocytes differentiation and fat storage. PPARβ/δ is involved in control and management of adipogenesis. While PPARα mediates the hypolipemiant actions of fibrates, PPARγ is the receptor for thiazolidinediones (glitazones) reccomended in type 2 diabetes treatment; by binding to PPARγ, glitazones modulates transcription of genes involved in lipid and carbohydrate metabolism." @default.
- W2937591719 created "2019-04-25" @default.
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- W2937591719 date "2012-01-01" @default.
- W2937591719 modified "2023-09-22" @default.
- W2937591719 title "PPARs: FUNCŢII FIZIOLOGICE ŞI ROLURI FARMACOLOGICE ALE AGONIŞTILOR ÎN BOLILE UMANE (Nota II)" @default.
- W2937591719 hasPublicationYear "2012" @default.
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