FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937622034> ?p ?o ?g. }

• W2937622034 endingPage "1928" @default.
• W2937622034 startingPage "1928" @default.
• W2937622034 abstract "With the aim of contributing to the knowledge about their potential therapeutic activity, we determined the biological activities of cyanidin and its selected O-glycosides in relation to erythrocytes (RBCs) and human dermal vascular endothelial cells (HMEC-1). Furthermore, on the basis of changes in the physical/functional properties of the cells, the structure–activity relationships of the compounds were determined. Concerning erythrocytes, we analyzed the antioxidant activity of the compounds and their impact on the RBCs’ shape and transmembrane potential. The compounds’ cytotoxic activity, ability to modulate apoptosis, cell cycle, and intracellular ROS generation, as well as inhibitory activity against AAPH-inducted oxidative stress, were determined in relation to HMEC-1 cells. We demonstrated that biological activity of cyanidin and its O-glycosides strongly depends on the number and type of sugar substituents, and varies depending on the extracellular environment and type of cells. The compounds are practically non-cytotoxic, and do not induce apoptosis or disturb the progression of the cell cycle. Additionally, the compounds alter the shape of RBCs, but they do not affect their transmembrane potential. They effectively protect erythrocytes against free radicals and affect intracellular reactive oxygen spices (ROS) generation under physiological and AAPH-induced oxidative stress conditions. Our results suggest a potential beneficial effect of cyanidin on the cardiovascular system." @default.
• W2937622034 created "2019-04-25" @default.
• W2937622034 creator A5007355757 @default.
• W2937622034 creator A5009853761 @default.
• W2937622034 creator A5045882835 @default.
• W2937622034 creator A5059033608 @default.
• W2937622034 creator A5081423888 @default.
• W2937622034 creator A5038338426 @default.
• W2937622034 date "2019-04-19" @default.
• W2937622034 modified "2023-10-18" @default.
• W2937622034 title "The Impact of O-Glycosylation on Cyanidin Interaction with RBCs and HMEC-1 Cells—Structure–Activity Relationships" @default.
• W2937622034 cites W1661335348 @default.
• W2937622034 cites W1765735955 @default.
• W2937622034 cites W1860682280 @default.
• W2937622034 cites W1965644436 @default.
• W2937622034 cites W1968985568 @default.
• W2937622034 cites W1970298804 @default.
• W2937622034 cites W1985189279 @default.
• W2937622034 cites W1992658935 @default.
• W2937622034 cites W2012298718 @default.
• W2937622034 cites W2012730409 @default.
• W2937622034 cites W2013805275 @default.
• W2937622034 cites W2015560109 @default.
• W2937622034 cites W2021171647 @default.
• W2937622034 cites W2022291942 @default.
• W2937622034 cites W2027257172 @default.
• W2937622034 cites W2032065314 @default.
• W2937622034 cites W2040036700 @default.
• W2937622034 cites W2051956018 @default.
• W2937622034 cites W2053316950 @default.
• W2937622034 cites W2053987912 @default.
• W2937622034 cites W2059835019 @default.
• W2937622034 cites W2061831818 @default.
• W2937622034 cites W2066728317 @default.
• W2937622034 cites W2068362976 @default.
• W2937622034 cites W2070261059 @default.
• W2937622034 cites W2080199719 @default.
• W2937622034 cites W2081413041 @default.
• W2937622034 cites W2081720173 @default.
• W2937622034 cites W2084011431 @default.
• W2937622034 cites W2098388282 @default.
• W2937622034 cites W2103481916 @default.
• W2937622034 cites W2104493858 @default.
• W2937622034 cites W2108450494 @default.
• W2937622034 cites W2115256145 @default.
• W2937622034 cites W2119331100 @default.
• W2937622034 cites W2122088022 @default.
• W2937622034 cites W2124592604 @default.
• W2937622034 cites W2143132516 @default.
• W2937622034 cites W2151896530 @default.
• W2937622034 cites W2169662236 @default.
• W2937622034 cites W2517613350 @default.
• W2937622034 cites W2523341096 @default.
• W2937622034 cites W2523612217 @default.
• W2937622034 cites W2751037842 @default.
• W2937622034 cites W2791838466 @default.
• W2937622034 cites W2799510539 @default.
• W2937622034 cites W3086807137 @default.
• W2937622034 cites W4254090491 @default.
• W2937622034 doi "https://doi.org/10.3390/ijms20081928" @default.
• W2937622034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6514962" @default.
• W2937622034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31010130" @default.
• W2937622034 hasPublicationYear "2019" @default.
• W2937622034 type Work @default.
• W2937622034 sameAs 2937622034 @default.
• W2937622034 citedByCount "10" @default.
• W2937622034 countsByYear W29376220342021 @default.
• W2937622034 countsByYear W29376220342022 @default.
• W2937622034 countsByYear W29376220342023 @default.
• W2937622034 crossrefType "journal-article" @default.
• W2937622034 hasAuthorship W2937622034A5007355757 @default.
• W2937622034 hasAuthorship W2937622034A5009853761 @default.
• W2937622034 hasAuthorship W2937622034A5038338426 @default.
• W2937622034 hasAuthorship W2937622034A5045882835 @default.
• W2937622034 hasAuthorship W2937622034A5059033608 @default.
• W2937622034 hasAuthorship W2937622034A5081423888 @default.
• W2937622034 hasBestOaLocation W29376220341 @default.
• W2937622034 hasConcept C109316439 @default.
• W2937622034 hasConcept C154317977 @default.
• W2937622034 hasConcept C170493617 @default.
• W2937622034 hasConcept C185592680 @default.
• W2937622034 hasConcept C190283241 @default.
• W2937622034 hasConcept C202751555 @default.
• W2937622034 hasConcept C24530287 @default.
• W2937622034 hasConcept C2776151105 @default.
• W2937622034 hasConcept C2778004101 @default.
• W2937622034 hasConcept C28406088 @default.
• W2937622034 hasConcept C48349386 @default.
• W2937622034 hasConcept C55493867 @default.
• W2937622034 hasConcept C57600042 @default.
• W2937622034 hasConcept C79879829 @default.
• W2937622034 hasConcept C86803240 @default.
• W2937622034 hasConcept C95444343 @default.
• W2937622034 hasConceptScore W2937622034C109316439 @default.
• W2937622034 hasConceptScore W2937622034C154317977 @default.
• W2937622034 hasConceptScore W2937622034C170493617 @default.
• W2937622034 hasConceptScore W2937622034C185592680 @default.
• W2937622034 hasConceptScore W2937622034C190283241 @default.

• next