Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937645066> ?p ?o ?g. }
- W2937645066 endingPage "R90" @default.
- W2937645066 startingPage "R76" @default.
- W2937645066 abstract "Thyroid hormones have a central role in cardiovascular homeostasis. In myocardium, these hormones stimulate both diastolic myocardial relaxation and systolic myocardial contraction, have a pro-angiogenic effect and an important role in extracellular matrix maintenance. Thyroid hormones modulate cardiac mitochondrial function. Dysfunction of thyroid axis impairs myocardial bioenergetic status. Both overt and subclinical hypothyroidism are associated with a higher incidence of coronary events and an increased risk of heart failure progression. Endothelial function is also impaired in hypothyroid state, with decreased nitric oxide-mediated vascular relaxation. In heart disease, particularly in ischemic heart disease, abnormalities in thyroid hormone levels are common and are an important factor to be considered. In fact, low thyroid hormone levels should be interpreted as a cardiovascular risk factor. Regarding ischemic heart disease, during the late post-myocardial infarction period, thyroid hormones modulate left ventricular structure, function and geometry. Dysfunction of thyroid axis might even be more prevalent in the referred condition since there is an upregulation of type 3 deiodinase in myocardium, producing a state of local cardiac hypothyroidism. In this focused review, we summarize the central pathophysiological and clinical links between altered thyroid function and ischemic heart disease. Finally, we highlight the potential benefits of thyroid hormone supplementation as a therapeutic target in ischemic heart disease." @default.
- W2937645066 created "2019-04-25" @default.
- W2937645066 creator A5007213349 @default.
- W2937645066 creator A5009596234 @default.
- W2937645066 creator A5038788307 @default.
- W2937645066 creator A5042670390 @default.
- W2937645066 creator A5084846260 @default.
- W2937645066 date "2019-05-01" @default.
- W2937645066 modified "2023-10-16" @default.
- W2937645066 title "The impact of thyroid hormone dysfunction on ischemic heart disease" @default.
- W2937645066 cites W1533901948 @default.
- W2937645066 cites W1590426104 @default.
- W2937645066 cites W1969650068 @default.
- W2937645066 cites W1972669138 @default.
- W2937645066 cites W1975897819 @default.
- W2937645066 cites W1977065440 @default.
- W2937645066 cites W1978801392 @default.
- W2937645066 cites W1983800701 @default.
- W2937645066 cites W1985047970 @default.
- W2937645066 cites W1985991957 @default.
- W2937645066 cites W1987135328 @default.
- W2937645066 cites W1987475341 @default.
- W2937645066 cites W1990385348 @default.
- W2937645066 cites W1991926339 @default.
- W2937645066 cites W1994930939 @default.
- W2937645066 cites W1995656522 @default.
- W2937645066 cites W1996039273 @default.
- W2937645066 cites W1996745436 @default.
- W2937645066 cites W1998910747 @default.
- W2937645066 cites W2006532134 @default.
- W2937645066 cites W2008122954 @default.
- W2937645066 cites W2008168778 @default.
- W2937645066 cites W2008390809 @default.
- W2937645066 cites W2009774232 @default.
- W2937645066 cites W2013644808 @default.
- W2937645066 cites W2014579000 @default.
- W2937645066 cites W2017402045 @default.
- W2937645066 cites W2019260258 @default.
- W2937645066 cites W2020116931 @default.
- W2937645066 cites W2022008899 @default.
- W2937645066 cites W2023549924 @default.
- W2937645066 cites W2026642732 @default.
- W2937645066 cites W2031864923 @default.
- W2937645066 cites W2032698331 @default.
- W2937645066 cites W2032970792 @default.
- W2937645066 cites W2033340209 @default.
- W2937645066 cites W2034349206 @default.
- W2937645066 cites W2038464170 @default.
- W2937645066 cites W2039781981 @default.
- W2937645066 cites W2041509950 @default.
- W2937645066 cites W2046316442 @default.
- W2937645066 cites W2046429224 @default.
- W2937645066 cites W2047308744 @default.
- W2937645066 cites W2049307843 @default.
- W2937645066 cites W2051683103 @default.
- W2937645066 cites W2051688636 @default.
- W2937645066 cites W2054501810 @default.
- W2937645066 cites W2057188227 @default.
- W2937645066 cites W2059540036 @default.
- W2937645066 cites W2062044444 @default.
- W2937645066 cites W2066358728 @default.
- W2937645066 cites W2070969828 @default.
- W2937645066 cites W2071154263 @default.
- W2937645066 cites W2072431132 @default.
- W2937645066 cites W2082088375 @default.
- W2937645066 cites W2083557171 @default.
- W2937645066 cites W2085556990 @default.
- W2937645066 cites W2088862034 @default.
- W2937645066 cites W2090338582 @default.
- W2937645066 cites W2090697980 @default.
- W2937645066 cites W2093819773 @default.
- W2937645066 cites W2095056572 @default.
- W2937645066 cites W2095609107 @default.
- W2937645066 cites W2101230864 @default.
- W2937645066 cites W2102283202 @default.
- W2937645066 cites W2103065406 @default.
- W2937645066 cites W2106074626 @default.
- W2937645066 cites W2107937411 @default.
- W2937645066 cites W2111181406 @default.
- W2937645066 cites W2112380741 @default.
- W2937645066 cites W2116760536 @default.
- W2937645066 cites W2123471730 @default.
- W2937645066 cites W2127890364 @default.
- W2937645066 cites W2128219988 @default.
- W2937645066 cites W2129655317 @default.
- W2937645066 cites W2133338733 @default.
- W2937645066 cites W2134697644 @default.
- W2937645066 cites W2135009630 @default.
- W2937645066 cites W2140936682 @default.
- W2937645066 cites W2142296338 @default.
- W2937645066 cites W2143081191 @default.
- W2937645066 cites W2145070197 @default.
- W2937645066 cites W2148502290 @default.
- W2937645066 cites W2149297891 @default.
- W2937645066 cites W2150063597 @default.
- W2937645066 cites W2150702956 @default.
- W2937645066 cites W2153382168 @default.
- W2937645066 cites W2165336308 @default.