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- W2937646857 abstract "It is well known that obesity is involved in various metabolic disorders that induce chronic inflammation in adipose tissue. In order to investigate the correlation of fat tissue increases and temporary/chronic inflammation, we evaluated the lipid producing ability of subcutaneous pre-adipocytes in different culture conditions with conditioned medium from inflammatory macrophages. When pre-adipocytes were incubated with conditioned medium from inflammatory macrophages in the process of differentiation, their production of lipid droplets was inhibited and the expression of PPARγ and FABP4 mRNAs was also at a low level. In contrast, when pre-adipocytes were treated with conditioned medium from inflammatory macrophages before the initiation of differentiation, lipid droplets production was increased significantly at the later step of adipocyte differentiation. Further, the expression levels of PPARγ and FABP4 mRNAs were not changed significantly, however, the number of cells was dramatically increased. These pre-adipocyte alteration was also reproduced by the addition of TNF-α, a known cytokine for inflammatory macrophages, and they were abrogated in the presence of TNF-α antagonist. These results suggest that a temporary inflammation in adipose tissue may increase the number of precursor adipocytes, which may then contribute to the increase of mature fat tissue. In addition, chronic inflammation due to obesity may deteriorate metabolism of pre-adipocytes by inhibiting the differentiation, leading to adipose tissue dysfunction." @default.
- W2937646857 created "2019-04-25" @default.
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- W2937646857 date "2019-05-01" @default.
- W2937646857 modified "2023-09-30" @default.
- W2937646857 title "885 The secretion of TNF-α by inflammatory macrophages has dual effects on subcutaneous adipose precursor cells: inhibition of differentiation and activation of proliferation" @default.
- W2937646857 doi "https://doi.org/10.1016/j.jid.2019.03.961" @default.
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