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• W2937651399 abstract "This review summarizes the current dosing recommendations for antiretroviral (ARV) drugs in the international pediatric guidelines of the World Health Organization (WHO), US Department of Health and Human Services (DHHS), and Pediatric European Network for Treatment of AIDS (PENTA), and evaluates the research that informed these approaches. We further explore the role of data generated through therapeutic drug monitoring in optimizing the dosing of ARVs in children.A PubMed search was conducted for the literature on ARV dosing published in English. In addition, the registration documentation of European Medicines Agency and the US Food and Drug Administration for currently used ARVs and studies referenced by the WHO, DHHS, and EMA guidelines were screened. Resulting publications were screened for papers containing data on the area under the concentration-time curve, trough concentration, and peak concentration. Studies with enrolled participants with a median or mean age of ≥18 years were excluded. No restriction on publishing date was applied.Pediatric ARV dosing is frequently based on data obtained from small studies and is often simplified to facilitate dosing in the context of a public health approach. Pharmacokinetic parameters of pediatric ARVs are subject to high interpatient variation and this leads to a potential risk of underdosing or overdosing when drugs are used in real life. To ensure optimal use of ARVs and validate dosing recommendations for children, it is essential to monitor ARV dosing more thoroughly with larger sample sizes and to include diverse subpopulations. Therapeutic drug monitoring data generated in children, where available and affordable, have the potential to enhance our understanding of the appropriateness of simplified pediatric dosing strategies recommended using a public health approach and to uncover suboptimal dosing or other unanticipated issues postmarketing, further facilitating the ultimate goal of optimizing pediatric ARV treatment." @default.
• W2937651399 created "2019-04-25" @default.
• W2937651399 creator A5009887015 @default.
• W2937651399 creator A5011349295 @default.
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• W2937651399 creator A5021647610 @default.
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• W2937651399 creator A5085465326 @default.
• W2937651399 date "2019-08-01" @default.
• W2937651399 modified "2023-10-18" @default.
• W2937651399 title "Optimizing Pediatric Dosing Recommendations and Treatment Management of Antiretroviral Drugs Using Therapeutic Drug Monitoring Data in Children Living With HIV" @default.
• W2937651399 cites W1483464410 @default.
• W2937651399 cites W1484620035 @default.
• W2937651399 cites W1506412639 @default.
• W2937651399 cites W1517608807 @default.
• W2937651399 cites W1517653170 @default.
• W2937651399 cites W1519919410 @default.
• W2937651399 cites W1566549789 @default.
• W2937651399 cites W1586266234 @default.
• W2937651399 cites W1599520248 @default.
• W2937651399 cites W1730588523 @default.
• W2937651399 cites W1927513137 @default.
• W2937651399 cites W1941445578 @default.
• W2937651399 cites W1964622173 @default.
• W2937651399 cites W1967503024 @default.
• W2937651399 cites W1971771720 @default.
• W2937651399 cites W1972528060 @default.
• W2937651399 cites W1975978056 @default.
• W2937651399 cites W1981712752 @default.
• W2937651399 cites W1990069515 @default.
• W2937651399 cites W1993769510 @default.
• W2937651399 cites W1996364592 @default.
• W2937651399 cites W2001356815 @default.
• W2937651399 cites W2007831756 @default.
• W2937651399 cites W2009367857 @default.
• W2937651399 cites W2024739204 @default.
• W2937651399 cites W2032244821 @default.
• W2937651399 cites W2032588857 @default.
• W2937651399 cites W2040468325 @default.
• W2937651399 cites W2040553910 @default.
• W2937651399 cites W2042416176 @default.
• W2937651399 cites W2049710122 @default.
• W2937651399 cites W2051116409 @default.
• W2937651399 cites W2052298260 @default.
• W2937651399 cites W2058499501 @default.
• W2937651399 cites W2058627164 @default.
• W2937651399 cites W2070983157 @default.
• W2937651399 cites W2072666308 @default.
• W2937651399 cites W2073613890 @default.
• W2937651399 cites W2075531822 @default.
• W2937651399 cites W2075735668 @default.
• W2937651399 cites W2076861622 @default.
• W2937651399 cites W2078358655 @default.
• W2937651399 cites W2079573278 @default.
• W2937651399 cites W2083157920 @default.
• W2937651399 cites W2084180691 @default.
• W2937651399 cites W2086244671 @default.
• W2937651399 cites W2088297139 @default.
• W2937651399 cites W2098605123 @default.
• W2937651399 cites W2099837065 @default.
• W2937651399 cites W2101251098 @default.
• W2937651399 cites W2106737113 @default.
• W2937651399 cites W2106737419 @default.
• W2937651399 cites W2106855395 @default.
• W2937651399 cites W2108000358 @default.
• W2937651399 cites W2108794518 @default.
• W2937651399 cites W2111873900 @default.
• W2937651399 cites W2112267775 @default.
• W2937651399 cites W2112710992 @default.
• W2937651399 cites W2116004391 @default.
• W2937651399 cites W2117312836 @default.
• W2937651399 cites W2119239704 @default.
• W2937651399 cites W2122527560 @default.
• W2937651399 cites W2122846238 @default.
• W2937651399 cites W2124543441 @default.
• W2937651399 cites W2127252924 @default.
• W2937651399 cites W2130191347 @default.
• W2937651399 cites W2135816098 @default.
• W2937651399 cites W2135892517 @default.
• W2937651399 cites W2137569461 @default.
• W2937651399 cites W2137884486 @default.
• W2937651399 cites W2141357379 @default.
• W2937651399 cites W2141400171 @default.
• W2937651399 cites W2142538462 @default.
• W2937651399 cites W2143292175 @default.
• W2937651399 cites W2149185709 @default.
• W2937651399 cites W2150087465 @default.
• W2937651399 cites W2168369403 @default.
• W2937651399 cites W2253998502 @default.
• W2937651399 cites W2300467881 @default.
• W2937651399 cites W2319374306 @default.
• W2937651399 cites W2320157961 @default.
• W2937651399 cites W2322179694 @default.
• W2937651399 cites W2326437656 @default.
• W2937651399 cites W2344624438 @default.
• W2937651399 cites W2409582997 @default.
• W2937651399 cites W2409673291 @default.

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