FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937665633> ?p ?o ?g. }

• W2937665633 endingPage "425" @default.
• W2937665633 startingPage "415" @default.
• W2937665633 abstract "Positron emission tomography studies examining differences in D1-dopamine receptor binding between control subjects and patients with schizophrenia have been inconsistent, reporting higher, lower, and no difference in the frontal cortex. Exposure to antipsychotic medication has been suggested to be a likely source of this heterogeneity, and thus there is a need for studies of patients at early stages of the disorder who have not been exposed to such drugs.Here, we compared 17 healthy control subjects and 18 first-episode neuroleptic naive patients with schizophrenia or schizophreniform psychosis using positron emission tomography and the D1-dopamine receptor radioligand [11C]SCH23390.We observed a statistically significant difference in the dorsolateral prefrontal cortex. Contrary to our expectations, patients had less D1-dopamine receptor availability with a moderate effect size. In a Bayesian analysis, we show that the data are over 50 times more likely to have occurred under the decrease as opposed to the increase hypothesis. This effect was not global, as our analysis showed that the null hypothesis was preferred over either hypothesis in the striatum.This investigation represents the largest single sample of neuroleptic-naive patients examined for D1-dopamine receptor availability using PET and suggests a reduction of prefrontal D1-dopamine receptor density in the pathophysiology of schizophrenia. However, further work will be required to reach a consensus." @default.
• W2937665633 created "2019-04-25" @default.
• W2937665633 creator A5015456048 @default.
• W2937665633 creator A5019832317 @default.
• W2937665633 creator A5061483789 @default.
• W2937665633 creator A5071263952 @default.
• W2937665633 creator A5081327813 @default.
• W2937665633 date "2019-04-08" @default.
• W2937665633 modified "2023-10-01" @default.
• W2937665633 title "D1-Dopamine Receptor Availability in First-Episode Neuroleptic Naive Psychosis Patients" @default.
• W2937665633 cites W1518890501 @default.
• W2937665633 cites W1556779599 @default.
• W2937665633 cites W1633465406 @default.
• W2937665633 cites W1819927624 @default.
• W2937665633 cites W1933819638 @default.
• W2937665633 cites W1936296662 @default.
• W2937665633 cites W1965819630 @default.
• W2937665633 cites W1979792701 @default.
• W2937665633 cites W1985458776 @default.
• W2937665633 cites W1987592373 @default.
• W2937665633 cites W1988668967 @default.
• W2937665633 cites W1990866533 @default.
• W2937665633 cites W1992381398 @default.
• W2937665633 cites W1994357188 @default.
• W2937665633 cites W1994517931 @default.
• W2937665633 cites W1995778321 @default.
• W2937665633 cites W2003171277 @default.
• W2937665633 cites W2003233267 @default.
• W2937665633 cites W2016984971 @default.
• W2937665633 cites W2020844317 @default.
• W2937665633 cites W2024053893 @default.
• W2937665633 cites W2029313053 @default.
• W2937665633 cites W2029809954 @default.
• W2937665633 cites W2032257903 @default.
• W2937665633 cites W2032499294 @default.
• W2937665633 cites W2033524647 @default.
• W2937665633 cites W2037698344 @default.
• W2937665633 cites W2051190325 @default.
• W2937665633 cites W2054843129 @default.
• W2937665633 cites W2058396154 @default.
• W2937665633 cites W2063237661 @default.
• W2937665633 cites W2064446115 @default.
• W2937665633 cites W2067068908 @default.
• W2937665633 cites W2072069319 @default.
• W2937665633 cites W2072846096 @default.
• W2937665633 cites W2074570091 @default.
• W2937665633 cites W2075744055 @default.
• W2937665633 cites W2077767624 @default.
• W2937665633 cites W2082750652 @default.
• W2937665633 cites W2086047714 @default.
• W2937665633 cites W2086317186 @default.
• W2937665633 cites W2086392637 @default.
• W2937665633 cites W2089686687 @default.
• W2937665633 cites W2092457592 @default.
• W2937665633 cites W2094350394 @default.
• W2937665633 cites W2095489655 @default.
• W2937665633 cites W2101948750 @default.
• W2937665633 cites W2103655132 @default.
• W2937665633 cites W2110443153 @default.
• W2937665633 cites W2111335060 @default.
• W2937665633 cites W2117671988 @default.
• W2937665633 cites W2119303750 @default.
• W2937665633 cites W2120063529 @default.
• W2937665633 cites W2121576656 @default.
• W2937665633 cites W2123510839 @default.
• W2937665633 cites W2138021751 @default.
• W2937665633 cites W2145602532 @default.
• W2937665633 cites W2147949752 @default.
• W2937665633 cites W2149634179 @default.
• W2937665633 cites W2159733079 @default.
• W2937665633 cites W2165545769 @default.
• W2937665633 cites W2183350258 @default.
• W2937665633 cites W2263057920 @default.
• W2937665633 cites W2296537658 @default.
• W2937665633 cites W2297919795 @default.
• W2937665633 cites W2342015317 @default.
• W2937665633 cites W2383588211 @default.
• W2937665633 cites W2406022298 @default.
• W2937665633 cites W2413355686 @default.
• W2937665633 cites W2606633119 @default.
• W2937665633 cites W2610765860 @default.
• W2937665633 cites W2752770718 @default.
• W2937665633 cites W2790736377 @default.
• W2937665633 cites W2807132081 @default.
• W2937665633 cites W2885315748 @default.
• W2937665633 cites W2950474432 @default.
• W2937665633 cites W4230920194 @default.
• W2937665633 cites W4255197246 @default.
• W2937665633 doi "https://doi.org/10.1093/ijnp/pyz017" @default.
• W2937665633 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6600463" @default.
• W2937665633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30958880" @default.
• W2937665633 hasPublicationYear "2019" @default.
• W2937665633 type Work @default.
• W2937665633 sameAs 2937665633 @default.
• W2937665633 citedByCount "24" @default.
• W2937665633 countsByYear W29376656332019 @default.
• W2937665633 countsByYear W29376656332020 @default.
• W2937665633 countsByYear W29376656332021 @default.

• next