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- W2937682709 abstract "Despite the development of nanomaterials with high-Z elements for radiosensitizers, most of them suffer from their oxygen-dependent behavior in hypoxic tumor, nonideal selectivity to tumor, or inevasible damages to normal tissue, greatly limiting their further applications. Herein, we develop a Schottky-type heterostructure of Au-Bi2S3 with promising ability of reactive free radicals generation under X-ray irradiation for selectively enhancing radiotherapeutic efficacy by catalyzing intracellular H2O2 in tumor. On the one hand, like many other nanomaterials with rich high-Z elements, Au-Bi2S3 can deposit higher radiation dose within tumors in the form of high energy electrons. On the other hand, Au-Bi2S3 can remarkably improve the utilization of a large number of X-ray-induced low energy electrons during radiotherapy for nonoxygen dependent free radicals generation even in hypoxic condition. This feature of Schottky-type heterostructures Au-Bi2S3 attributes to the generated Schottky barrier between metal Au and semiconductor Bi2S3, which can trap the X-ray-generated electrons and transfer them to Au, resulting in efficient separation of the electron-hole pairs. Then, because of the matched potential between the conduction band of Bi2S3 and overexpressed H2O2 within tumor, the Au-Bi2S3 HNSCs can decompose the intracellular H2O2 into highly toxic •OH for selective radiosensitization in tumor. As a consequence, this kind of nanoparticle provides an idea to develop rational designed Schottky-type heterostructures as efficient radiosensitizers for enhanced radiotherapy of cancer." @default.
- W2937682709 created "2019-04-25" @default.
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- W2937682709 date "2019-04-10" @default.
- W2937682709 modified "2023-10-10" @default.
- W2937682709 title "Enhanced Generation of Non-Oxygen Dependent Free Radicals by Schottky-type Heterostructures of Au–Bi<sub>2</sub>S<sub>3</sub> Nanoparticles <i>via</i> X-ray-Induced Catalytic Reaction for Radiosensitization" @default.
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- W2937682709 doi "https://doi.org/10.1021/acsnano.9b01818" @default.
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