Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937718797> ?p ?o ?g. }
- W2937718797 endingPage "10" @default.
- W2937718797 startingPage "1" @default.
- W2937718797 abstract "Background: The xenobiotics-induced liver injury is a clinical complication. Hence, finding new hepatoprotective strategies has clinical value. Oxidative stress and its subsequent complications are major mechanisms involved in xenobiotics-induced hepatotoxicity. Boldine is one of the most potent antioxidant molecules widely investigated for its protective properties in different experimental models. In the current study, the hepatoprotective properties of boldine and its potential mechanisms of hepatoprotection have been investigated. Methods: Rats received thioacetamide (TAA; 200 mg/kg, i.p) as a model of acute liver injury. Boldine (5, 10, 1nd 20 mg/kg; 24 hours intervals; oral) was administered as the hepatoprotective agent. Results: Liver injury was evident in TAA-treated animals (48 hours after TAA exposure) as a severe increase in serum level of liver injury biomarkers and histopathological alterations. Moreover, markers of oxidative stress were increased in liver tissue of TAA-treated rats. Assessment of mitochondrial indices of functionality revealed a significant decrease in mitochondrial dehydrogenases activity, the collapse of mitochondrial membrane potential, mitochondrial swelling and depletion of ATP content. It was found that boldine supplementation mitigated liver tissue markers of oxidative stress and improved mitochondrial indices of functionality in TAA-treated animals. Conclusion: The hepatoprotective properties of boldine might primarily rely on antioxidant and mitochondria protecting effects of this alkaloid." @default.
- W2937718797 created "2019-04-25" @default.
- W2937718797 creator A5007613558 @default.
- W2937718797 creator A5040542033 @default.
- W2937718797 creator A5045994707 @default.
- W2937718797 creator A5052115831 @default.
- W2937718797 creator A5084018887 @default.
- W2937718797 creator A5084556010 @default.
- W2937718797 date "2019-03-18" @default.
- W2937718797 modified "2023-10-11" @default.
- W2937718797 title "Boldine Supplementation Regulates Mitochondrial Function and Oxidative Stress in a Rat Model of Hepatotoxicity" @default.
- W2937718797 cites W1803451646 @default.
- W2937718797 cites W1958186397 @default.
- W2937718797 cites W1968494226 @default.
- W2937718797 cites W1969556388 @default.
- W2937718797 cites W1977194186 @default.
- W2937718797 cites W1982368101 @default.
- W2937718797 cites W1983475981 @default.
- W2937718797 cites W1985628991 @default.
- W2937718797 cites W1986810913 @default.
- W2937718797 cites W1988579516 @default.
- W2937718797 cites W2007019622 @default.
- W2937718797 cites W2007116346 @default.
- W2937718797 cites W2008068561 @default.
- W2937718797 cites W2009745919 @default.
- W2937718797 cites W2010371298 @default.
- W2937718797 cites W2012052762 @default.
- W2937718797 cites W2016409720 @default.
- W2937718797 cites W2016988514 @default.
- W2937718797 cites W2017804304 @default.
- W2937718797 cites W2018305706 @default.
- W2937718797 cites W2027258070 @default.
- W2937718797 cites W2028026620 @default.
- W2937718797 cites W2029016065 @default.
- W2937718797 cites W2044507716 @default.
- W2937718797 cites W2056878496 @default.
- W2937718797 cites W2057767639 @default.
- W2937718797 cites W2058293218 @default.
- W2937718797 cites W2061296029 @default.
- W2937718797 cites W2068048197 @default.
- W2937718797 cites W2069468756 @default.
- W2937718797 cites W2073976519 @default.
- W2937718797 cites W2074545478 @default.
- W2937718797 cites W2077815905 @default.
- W2937718797 cites W2097423163 @default.
- W2937718797 cites W2099546329 @default.
- W2937718797 cites W2107357628 @default.
- W2937718797 cites W2114918609 @default.
- W2937718797 cites W2121297790 @default.
- W2937718797 cites W2125911539 @default.
- W2937718797 cites W2132856398 @default.
- W2937718797 cites W2138313021 @default.
- W2937718797 cites W2152165298 @default.
- W2937718797 cites W2314083131 @default.
- W2937718797 cites W2321717177 @default.
- W2937718797 cites W2411945685 @default.
- W2937718797 cites W2470337695 @default.
- W2937718797 cites W2511678762 @default.
- W2937718797 cites W2517312334 @default.
- W2937718797 cites W2567367887 @default.
- W2937718797 cites W2579969776 @default.
- W2937718797 cites W2581465341 @default.
- W2937718797 cites W2581907880 @default.
- W2937718797 cites W2582619542 @default.
- W2937718797 cites W2582757639 @default.
- W2937718797 cites W2585446935 @default.
- W2937718797 cites W2605758780 @default.
- W2937718797 cites W2737815361 @default.
- W2937718797 cites W40739316 @default.
- W2937718797 cites W4293247451 @default.
- W2937718797 cites W79667893 @default.
- W2937718797 doi "https://doi.org/10.15171/ps.2019.1" @default.
- W2937718797 hasPublicationYear "2019" @default.
- W2937718797 type Work @default.
- W2937718797 sameAs 2937718797 @default.
- W2937718797 citedByCount "17" @default.
- W2937718797 countsByYear W29377187972019 @default.
- W2937718797 countsByYear W29377187972020 @default.
- W2937718797 countsByYear W29377187972021 @default.
- W2937718797 countsByYear W29377187972022 @default.
- W2937718797 countsByYear W29377187972023 @default.
- W2937718797 crossrefType "journal-article" @default.
- W2937718797 hasAuthorship W2937718797A5007613558 @default.
- W2937718797 hasAuthorship W2937718797A5040542033 @default.
- W2937718797 hasAuthorship W2937718797A5045994707 @default.
- W2937718797 hasAuthorship W2937718797A5052115831 @default.
- W2937718797 hasAuthorship W2937718797A5084018887 @default.
- W2937718797 hasAuthorship W2937718797A5084556010 @default.
- W2937718797 hasBestOaLocation W29377187971 @default.
- W2937718797 hasConcept C115448650 @default.
- W2937718797 hasConcept C181199279 @default.
- W2937718797 hasConcept C185592680 @default.
- W2937718797 hasConcept C2776151105 @default.
- W2937718797 hasConcept C2776514860 @default.
- W2937718797 hasConcept C2776637226 @default.
- W2937718797 hasConcept C2778004101 @default.
- W2937718797 hasConcept C2781057625 @default.
- W2937718797 hasConcept C28859421 @default.