FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937721881> ?p ?o ?g. }

• W2937721881 endingPage "152" @default.
• W2937721881 startingPage "147" @default.
• W2937721881 abstract "Cholesteryl ester transfer protein (CETP) inhibitor-mediated induction of HDL-cholesterol has no effect on the protection from cardiovascular disease (CVD). However, the mechanism is still unknown. Data on the effects of this class of drugs on subclasses of HDL are either limited or insufficient. In this study, we investigated the effect of evacetrapib, a CETP inhibitor, on subclasses of HDL in patients with atherosclerotic cardiovascular disease or diabetes.Baseline and 3-month post-treatment samples from atorvastatin 40 mg plus evacetrapib 130 mg (n = 70) and atorvastatin 40 mg plus placebo (n = 30) arms were used for this purpose. Four subclasses of HDL (large HDL, medium HDL, small HDL, and preβ-1 HDL) were separated according to their size and quantified by densitometry using a recently developed native polyacrylamide gel electrophoresis (PAGE) system.Relative to placebo, while evacetrapib treatment dramatically increased large HDL and medium HDL subclasses, it significantly reduced small HDL (27%) as well as preβ-1 HDL (36%) particles. Evacetrapib treatment reduced total LDL, but also resulted in polydisperse LDL with LDL particles larger and smaller than the LDL subclasses of the placebo group.Evacetrapib reduced preβ-1 HDL and small HDL in patients with ASCVD or diabetes on statin. Preβ-1 HDL and medium HDL are negatively interrelated. The results could give a clue to understand the effect of CETP inhibitors on cardiovascular outcomes." @default.
• W2937721881 created "2019-04-25" @default.
• W2937721881 creator A5012278873 @default.
• W2937721881 creator A5018956614 @default.
• W2937721881 creator A5023717577 @default.
• W2937721881 creator A5057049239 @default.
• W2937721881 creator A5065582421 @default.
• W2937721881 creator A5070498614 @default.
• W2937721881 creator A5078164215 @default.
• W2937721881 creator A5088691885 @default.
• W2937721881 date "2019-06-01" @default.
• W2937721881 modified "2023-10-16" @default.
• W2937721881 title "Evacetrapib reduces preβ-1 HDL in patients with atherosclerotic cardiovascular disease or diabetes" @default.
• W2937721881 cites W1552121147 @default.
• W2937721881 cites W1591670239 @default.
• W2937721881 cites W1607399348 @default.
• W2937721881 cites W1860908381 @default.
• W2937721881 cites W1967600226 @default.
• W2937721881 cites W1977321522 @default.
• W2937721881 cites W1989242866 @default.
• W2937721881 cites W2000754433 @default.
• W2937721881 cites W2006921001 @default.
• W2937721881 cites W2021309429 @default.
• W2937721881 cites W2025158923 @default.
• W2937721881 cites W2034601582 @default.
• W2937721881 cites W2039537157 @default.
• W2937721881 cites W2048070048 @default.
• W2937721881 cites W2048760408 @default.
• W2937721881 cites W2052624323 @default.
• W2937721881 cites W2057930014 @default.
• W2937721881 cites W2061250936 @default.
• W2937721881 cites W2063693637 @default.
• W2937721881 cites W2072710993 @default.
• W2937721881 cites W2083392018 @default.
• W2937721881 cites W2083776047 @default.
• W2937721881 cites W2084336658 @default.
• W2937721881 cites W2088469003 @default.
• W2937721881 cites W2103507414 @default.
• W2937721881 cites W2104650041 @default.
• W2937721881 cites W2113504642 @default.
• W2937721881 cites W2118825330 @default.
• W2937721881 cites W2120303313 @default.
• W2937721881 cites W2123587181 @default.
• W2937721881 cites W2141731387 @default.
• W2937721881 cites W2143423245 @default.
• W2937721881 cites W2144530774 @default.
• W2937721881 cites W2159243445 @default.
• W2937721881 cites W2160230170 @default.
• W2937721881 cites W2165415015 @default.
• W2937721881 cites W2193506619 @default.
• W2937721881 cites W2401939130 @default.
• W2937721881 cites W2475308728 @default.
• W2937721881 cites W2523595584 @default.
• W2937721881 cites W2580930093 @default.
• W2937721881 cites W2605317660 @default.
• W2937721881 cites W2610131477 @default.
• W2937721881 cites W2616536890 @default.
• W2937721881 cites W2762777606 @default.
• W2937721881 cites W2764023940 @default.
• W2937721881 cites W2769619046 @default.
• W2937721881 cites W2609869432 @default.
• W2937721881 doi "https://doi.org/10.1016/j.atherosclerosis.2019.04.211" @default.
• W2937721881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6548311" @default.
• W2937721881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31054484" @default.
• W2937721881 hasPublicationYear "2019" @default.
• W2937721881 type Work @default.
• W2937721881 sameAs 2937721881 @default.
• W2937721881 citedByCount "8" @default.
• W2937721881 countsByYear W29377218812020 @default.
• W2937721881 countsByYear W29377218812021 @default.
• W2937721881 countsByYear W29377218812022 @default.
• W2937721881 countsByYear W29377218812023 @default.
• W2937721881 crossrefType "journal-article" @default.
• W2937721881 hasAuthorship W2937721881A5012278873 @default.
• W2937721881 hasAuthorship W2937721881A5018956614 @default.
• W2937721881 hasAuthorship W2937721881A5023717577 @default.
• W2937721881 hasAuthorship W2937721881A5057049239 @default.
• W2937721881 hasAuthorship W2937721881A5065582421 @default.
• W2937721881 hasAuthorship W2937721881A5070498614 @default.
• W2937721881 hasAuthorship W2937721881A5078164215 @default.
• W2937721881 hasAuthorship W2937721881A5088691885 @default.
• W2937721881 hasBestOaLocation W29377218811 @default.
• W2937721881 hasConcept C126322002 @default.
• W2937721881 hasConcept C134018914 @default.
• W2937721881 hasConcept C142724271 @default.
• W2937721881 hasConcept C204787440 @default.
• W2937721881 hasConcept C27081682 @default.
• W2937721881 hasConcept C2776839432 @default.
• W2937721881 hasConcept C2777482532 @default.
• W2937721881 hasConcept C2778096610 @default.
• W2937721881 hasConcept C2778163477 @default.
• W2937721881 hasConcept C2780072125 @default.
• W2937721881 hasConcept C45505151 @default.
• W2937721881 hasConcept C555293320 @default.
• W2937721881 hasConcept C71924100 @default.
• W2937721881 hasConceptScore W2937721881C126322002 @default.
• W2937721881 hasConceptScore W2937721881C134018914 @default.
• W2937721881 hasConceptScore W2937721881C142724271 @default.

• next