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• W29378151 abstract "ACTH stimulates steroidogenesis by acting on a single highly specific cell surface receptor in the adrenal cortex. ACTH also has weaker affinity for all the other four members of the melanocortin receptor family, which are expressed in a variety of tissues. The principal endogenous agonists for these other receptors are α- and γ- melanocyte stimulating hormones (α -and γ- MSH), but these peptides are unable to bind to the ACTH receptor. This chapter aims to describe the characterization of this receptor prior to its cloning in 1992 and the subsequent studies of receptor regulation and function. Finally, the defects of this receptor in human disease are described." @default.
• W29378151 created "2016-06-24" @default.
• W29378151 creator A5002070840 @default.
• W29378151 creator A5013780018 @default.
• W29378151 date "2003-01-01" @default.
• W29378151 modified "2023-09-26" @default.
• W29378151 title "The ACTH Receptor and Its Mutations" @default.
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• W29378151 doi "https://doi.org/10.1007/978-1-4615-0501-3_9" @default.
• W29378151 hasPublicationYear "2003" @default.
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