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• W2938001522 abstract "Apolipoprotein E ɛ4-allele (APOE-e4) is a major susceptibility factor across the spectrum of Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). The characterization of this shared risk using neuroimaging and clinicopathological phenotypes is desirable for biomarker development. In this thesis, we first conduct a systematic literature review to synthesize current knowledge on the relationship between APOE-e4 and hippocampal volumes in AD. We then study 298 patients (AD=250, DLB=48; 38 pathology-confirmed) to explore the association of APOE-e4 with hippocampal volumes, irrespective of clinical diagnosis. Across the AD/DLB spectrum, (1) hippocampal volumes were smaller with increasing APOE-e4 dosage, (2) learning performance was associated with hippocampal volumes only among APOE-e4 carriers, (3) APOE-e4 carriers performed worse on long-delay word-recall. Hippocampal volumes were also inversely related to APOE-e4 dosage within the AD and DLB groups. We provide evidence that APOE-e4 is linked to hippocampal atrophy across the AD/DLB spectrum, possibly via shared neurodegenerative mechanisms.%%%%M.Sc." @default.
• W2938001522 created "2019-04-25" @default.
• W2938001522 creator A5055886861 @default.
• W2938001522 date "2018-11-01" @default.
• W2938001522 modified "2023-09-27" @default.
• W2938001522 title "Apolipoprotein E polymorphism and hippocampal atrophy across the spectrum of Alzheimer’s disease and dementia with Lewy bodies" @default.
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