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• W2938007656 abstract "Introduction: Epstein–Barr virus (EBV) infects more than 95% of the world’s population and is associated with infectious mononucleosis as well as a number of cancers in various geographical locations. Despite its significant health burden, no licenced prophylactic or therapeutic vaccines are available.Areas covered: Over the last two decades, our understanding of the role of EBV infection in the pathogenesis and immune regulation of EBV-associated diseases has provided new lines of research to conceptualize various novel prophylactic and therapeutic approaches to control EBV-associated disease. In this review, we evaluate the prophylactic and therapeutic vaccine approaches against EBV and various immunotherapeutic strategies against a number of EBV-associated malignancies. This review also describes the existing and future prospects of improved EBV-targeted therapeutic strategies.Expert opinion: It is anticipated that these emerging strategies will provide answers for the major challenges in EBV vaccine development and help improve the efficacy of novel therapeutic strategies." @default.
• W2938007656 created "2019-04-25" @default.
• W2938007656 creator A5013841008 @default.
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• W2938007656 creator A5068930801 @default.
• W2938007656 creator A5080508449 @default.
• W2938007656 creator A5085415276 @default.
• W2938007656 date "2019-04-24" @default.
• W2938007656 modified "2023-10-18" @default.
• W2938007656 title "Prophylactic and therapeutic strategies for Epstein–Barr virus-associated diseases: emerging strategies for clinical development" @default.
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