FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938125116> ?p ?o ?g. }

• W2938125116 endingPage "844" @default.
• W2938125116 startingPage "839" @default.
• W2938125116 abstract "Objective: To elucidate the expression levels of key immune biomarkers, phosphate and tension homology deleted on chromosome ten (PTEN) and programmed cell death protein1(PD-1),of different immune tolerance pathway in classic Hodgkin's lymphoma (CHL) to further determine their clinical role and prognostic significance. Methods: The clinical features and prognostic factors of 56 CHL patients, who were admitted to the TianJin Medical University Cancer Institute from February 2003 to August 2013, were retrospectively analyzed. PTEN and PD-1 protein expression levels were analyzed by immunohistochemistry, Epstein-Barr virus encoded RNA (EBER) was performed by in situ hybridization assay. Correlations between the expression of biomarkers and clinicopathologic parameters were examined and survival analyses were performed. Results: This cohort of 56 CHL patients included 34 males and 22 females with a median age of 25 years (ranged from 7 to 71 years). In a univariate analysis, age≥45, IPS score >2, EBER positive, high expression of PTEN protein conferred inferior 5-year OS and 5-year PFS; In a multivariate model, age≥45, IPS score >2, EBER positive, high expression of PTEN protein were identified as the independent adverse prognostic factors for CHL. Conclusions: This study suggested for the first time that PTEN was independent prognostic immune biomarkers in CHL, which provided the novel therapeutic strategy of immune therapy for CHL.目的： 分析肿瘤免疫耐受信号通路的重要因子PD-1和PTEN在经典型霍奇金淋巴瘤（CHL）患者中的表达及其与患者临床特征和预后的相关性。 方法： 回顾性分析2003年2月至2013年8月诊治的56例CHL患者的临床资料。采用免疫组织化学染色法检测CHL患者PD-1和PTEN蛋白的表达，采用原位杂交法检测EBV及EBV编码的小mRNA（EBER），并结合患者的临床特征与生存状态进行相关性分析。 结果： ①56例患者中，男34例，女22例，中位年龄25（7~71）岁，PTEN阳性者11例（19.64%），PD-1阳性者14例（25.00%）。②PTEN和PD-1表达呈正相关（rs=0.320，P=0.016）；PTEN表达与Ann Arbor分期、IPS评分和有无大包块（≥5 cm）明显相关，PD-1仅与有无大包块相关（P值均<0.05）。③中位随访43（5~86）个月，多因素分析结果显示：年龄≥45岁（P<0.001）、IPS评分>2分（P=0.026）、EBER阳性（P=0.004）、PTEN蛋白高表达（P=0.035）是影响患者5年总生存的不良预后因素，也是影响5年无进展生存的不良预后因素（P值分别为0.007、0.014、0.002、0.024）。 结论： 肿瘤免疫逃逸信号通路因子PTEN与CHL患者的预后相关，对CHL患者的预后判断有一定作用，同时也为CHL的免疫治疗提供了新思路和理论依据。." @default.
• W2938125116 created "2019-04-25" @default.
• W2938125116 creator A5003145621 @default.
• W2938125116 creator A5011620122 @default.
• W2938125116 creator A5013576567 @default.
• W2938125116 creator A5020075019 @default.
• W2938125116 creator A5026999867 @default.
• W2938125116 creator A5033634359 @default.
• W2938125116 creator A5044617479 @default.
• W2938125116 creator A5045015030 @default.
• W2938125116 creator A5047365731 @default.
• W2938125116 creator A5049104706 @default.
• W2938125116 creator A5050921331 @default.
• W2938125116 creator A5085381594 @default.
• W2938125116 date "2018-10-14" @default.
• W2938125116 modified "2023-10-18" @default.
• W2938125116 title "[Expressions and prognostic significance of PTEN and PD-1 protein in patients with classical Hodgkin's lymphoma]." @default.
• W2938125116 cites W1544240937 @default.
• W2938125116 cites W1994292275 @default.
• W2938125116 cites W2034400622 @default.
• W2938125116 cites W2053336880 @default.
• W2938125116 cites W2057186227 @default.
• W2938125116 cites W2101039041 @default.
• W2938125116 cites W2121626779 @default.
• W2938125116 cites W2125616358 @default.
• W2938125116 cites W2133650808 @default.
• W2938125116 cites W2168937900 @default.
• W2938125116 cites W2202295242 @default.
• W2938125116 cites W2273004055 @default.
• W2938125116 cites W2340166080 @default.
• W2938125116 cites W2494958745 @default.
• W2938125116 cites W2520750334 @default.
• W2938125116 cites W2529923789 @default.
• W2938125116 cites W2547310148 @default.
• W2938125116 cites W2560367415 @default.
• W2938125116 cites W2626381041 @default.
• W2938125116 cites W2774391334 @default.
• W2938125116 cites W2784063247 @default.
• W2938125116 cites W364750170 @default.
• W2938125116 doi "https://doi.org/10.3760/cma.j.issn.0253-2727.2018.10.010" @default.
• W2938125116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7348287" @default.
• W2938125116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30373357" @default.
• W2938125116 hasPublicationYear "2018" @default.
• W2938125116 type Work @default.
• W2938125116 sameAs 2938125116 @default.
• W2938125116 citedByCount "1" @default.
• W2938125116 crossrefType "journal-article" @default.
• W2938125116 hasAuthorship W2938125116A5003145621 @default.
• W2938125116 hasAuthorship W2938125116A5011620122 @default.
• W2938125116 hasAuthorship W2938125116A5013576567 @default.
• W2938125116 hasAuthorship W2938125116A5020075019 @default.
• W2938125116 hasAuthorship W2938125116A5026999867 @default.
• W2938125116 hasAuthorship W2938125116A5033634359 @default.
• W2938125116 hasAuthorship W2938125116A5044617479 @default.
• W2938125116 hasAuthorship W2938125116A5045015030 @default.
• W2938125116 hasAuthorship W2938125116A5047365731 @default.
• W2938125116 hasAuthorship W2938125116A5049104706 @default.
• W2938125116 hasAuthorship W2938125116A5050921331 @default.
• W2938125116 hasAuthorship W2938125116A5085381594 @default.
• W2938125116 hasConcept C126322002 @default.
• W2938125116 hasConcept C143998085 @default.
• W2938125116 hasConcept C144301174 @default.
• W2938125116 hasConcept C190283241 @default.
• W2938125116 hasConcept C203014093 @default.
• W2938125116 hasConcept C204232928 @default.
• W2938125116 hasConcept C2777609662 @default.
• W2938125116 hasConcept C2779338263 @default.
• W2938125116 hasConcept C2779714933 @default.
• W2938125116 hasConcept C38180746 @default.
• W2938125116 hasConcept C502942594 @default.
• W2938125116 hasConcept C54355233 @default.
• W2938125116 hasConcept C71924100 @default.
• W2938125116 hasConcept C86554907 @default.
• W2938125116 hasConcept C86803240 @default.
• W2938125116 hasConcept C8891405 @default.
• W2938125116 hasConceptScore W2938125116C126322002 @default.
• W2938125116 hasConceptScore W2938125116C143998085 @default.
• W2938125116 hasConceptScore W2938125116C144301174 @default.
• W2938125116 hasConceptScore W2938125116C190283241 @default.
• W2938125116 hasConceptScore W2938125116C203014093 @default.
• W2938125116 hasConceptScore W2938125116C204232928 @default.
• W2938125116 hasConceptScore W2938125116C2777609662 @default.
• W2938125116 hasConceptScore W2938125116C2779338263 @default.
• W2938125116 hasConceptScore W2938125116C2779714933 @default.
• W2938125116 hasConceptScore W2938125116C38180746 @default.
• W2938125116 hasConceptScore W2938125116C502942594 @default.
• W2938125116 hasConceptScore W2938125116C54355233 @default.
• W2938125116 hasConceptScore W2938125116C71924100 @default.
• W2938125116 hasConceptScore W2938125116C86554907 @default.
• W2938125116 hasConceptScore W2938125116C86803240 @default.
• W2938125116 hasConceptScore W2938125116C8891405 @default.
• W2938125116 hasIssue "10" @default.
• W2938125116 hasLocation W29381251161 @default.
• W2938125116 hasOpenAccess W2938125116 @default.
• W2938125116 hasPrimaryLocation W29381251161 @default.
• W2938125116 hasRelatedWork W2012358159 @default.
• W2938125116 hasRelatedWork W2030813163 @default.
• W2938125116 hasRelatedWork W2039026873 @default.

• next