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- W2938183985 abstract "Cortisol is a glucocorticoid hormone that is produced by the adrenal glands and is secreted in response to stress. A previous study showed that cortisol reduced the formation of cell-cell contacts in human umbilical vein endothelial cells (HUVEC). Blood vessels play important roles in transporting nutrients and collecting waste products, and a decrease in cell-cell contacts in HUVEC causes various symptoms, such as edema and sagging. Lymphatic vessels have similar functions as blood vessels, and intercellular adhesion is important not only for HUVEC, but also for human dermal lymphatic microvascular endothelial cells (HMVEC). However, little research has been performed regarding the effect of glucocorticoid on the intercellular adhesion of HMVEC. In this study, we examined the effect of cortisol on the adhesion of HMVEC, and confirmed the effect of cortisol on HUVEC. First, we tested the impact of cortisol on cell viability. HUVEC and HMVEC treated with 5 μg/ml cortisol showed no cytotoxicity, whereas those treated with more than 10 μg/ml cortisol showed cytotoxicity. We thus decided to conduct our experiments with a concentration of cortisol lower than 5 μg/ml. In HMVEC cultured with cortisol, adhesion decreased significantly in a dose-dependent manner when compared to the untreated cells. It was also shown that cortisol treatment significantly decreased adhesion in HUVEC, a finding that corroborated previously reported research. We next tested several dozen plant extracts to determine whether they could enhance cell adhesion, and we found that a peach kernel (Semen persicae) extract could increase the adhesion of both HMVEC and HUVEC. It is known that increasing the intercellular adhesion of HUVEC and HMVEC can improve the functions of blood and lymphatic vessels, which in turn helps prevent edema and sagging. Our results indicate that cortisol can cause edema and sagging, and that the peach kernel extract has the potential to improve these symptoms." @default.
- W2938183985 created "2019-04-25" @default.
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- W2938183985 date "2019-05-01" @default.
- W2938183985 modified "2023-09-30" @default.
- W2938183985 title "423 The intercellular adhesion of human dermal lymphatic microvascular endothelial cells is decreased by cortisol and increased by peach kernel extract" @default.
- W2938183985 doi "https://doi.org/10.1016/j.jid.2019.03.499" @default.
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