FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938186903> ?p ?o ?g. }

• W2938186903 endingPage "5949" @default.
• W2938186903 startingPage "5936" @default.
• W2938186903 abstract "In eukaryotes and archaea, tRNA genes frequently contain introns, which are removed during maturation. However, biological roles of tRNA introns remain elusive. Here, we constructed a complete set of Saccharomyces cerevisiae strains in which the introns were removed from all the synonymous genes encoding 10 different tRNA species. All the intronless strains were viable, but the tRNAPheGAA and tRNATyrGUA intronless strains displayed slow growth, cold sensitivity and defective growth under respiratory conditions, indicating physiological importance of certain tRNA introns. Northern analyses revealed that removal of the introns from genes encoding three tRNAs reduced the amounts of the corresponding mature tRNAs, while it did not affect aminoacylation. Unexpectedly, the tRNALeuCAA intronless strain showed reduced 5.8S rRNA levels and abnormal nucleolar morphology. Because pseudouridine (Ψ) occurs at position 34 of the tRNAIleUAU anticodon in an intron-dependent manner, tRNAIleUAU in the intronless strain lost Ψ34. However, in a portion of tRNAIleUAU population, position 34 was converted into 5-carbamoylmethyluridine (ncm5U), which could reduce decoding fidelity. In summary, our results demonstrate that, while introns are dispensable for cell viability, some introns have diverse roles, such as ensuring proper growth under various conditions and controlling the appropriate anticodon modifications for accurate pairing with the codon." @default.
• W2938186903 created "2019-04-25" @default.
• W2938186903 creator A5001653266 @default.
• W2938186903 creator A5030338003 @default.
• W2938186903 creator A5054527620 @default.
• W2938186903 creator A5085703576 @default.
• W2938186903 date "2019-04-18" @default.
• W2938186903 modified "2023-10-05" @default.
• W2938186903 title "Impact of intron removal from tRNA genes on Saccharomyces cerevisiae" @default.
• W2938186903 cites W101969071 @default.
• W2938186903 cites W1515752517 @default.
• W2938186903 cites W1546300206 @default.
• W2938186903 cites W1780093098 @default.
• W2938186903 cites W1867346435 @default.
• W2938186903 cites W1968832089 @default.
• W2938186903 cites W1968950496 @default.
• W2938186903 cites W1970139184 @default.
• W2938186903 cites W1974992467 @default.
• W2938186903 cites W1975882670 @default.
• W2938186903 cites W1987143367 @default.
• W2938186903 cites W1988358280 @default.
• W2938186903 cites W2004122739 @default.
• W2938186903 cites W2019443139 @default.
• W2938186903 cites W2023220173 @default.
• W2938186903 cites W2033272594 @default.
• W2938186903 cites W2045399169 @default.
• W2938186903 cites W2047439787 @default.
• W2938186903 cites W2049424828 @default.
• W2938186903 cites W2051029292 @default.
• W2938186903 cites W2051568131 @default.
• W2938186903 cites W2055977185 @default.
• W2938186903 cites W2056381504 @default.
• W2938186903 cites W2062119499 @default.
• W2938186903 cites W2070324964 @default.
• W2938186903 cites W2075354975 @default.
• W2938186903 cites W2075483732 @default.
• W2938186903 cites W2091477066 @default.
• W2938186903 cites W2097483873 @default.
• W2938186903 cites W2102155883 @default.
• W2938186903 cites W2103116585 @default.
• W2938186903 cites W2106579945 @default.
• W2938186903 cites W2109525713 @default.
• W2938186903 cites W2111578963 @default.
• W2938186903 cites W2120276342 @default.
• W2938186903 cites W2121919944 @default.
• W2938186903 cites W2123171989 @default.
• W2938186903 cites W2124800414 @default.
• W2938186903 cites W2132750922 @default.
• W2938186903 cites W2139573380 @default.
• W2938186903 cites W2144269180 @default.
• W2938186903 cites W2146503498 @default.
• W2938186903 cites W2148399893 @default.
• W2938186903 cites W2153401759 @default.
• W2938186903 cites W2156206183 @default.
• W2938186903 cites W2156556259 @default.
• W2938186903 cites W2169805974 @default.
• W2938186903 cites W2223836536 @default.
• W2938186903 cites W2294340847 @default.
• W2938186903 cites W2472609315 @default.
• W2938186903 cites W2517913302 @default.
• W2938186903 cites W2710857726 @default.
• W2938186903 cites W2748141008 @default.
• W2938186903 cites W2771190723 @default.
• W2938186903 cites W594366972 @default.
• W2938186903 doi "https://doi.org/10.1093/nar/gkz270" @default.
• W2938186903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6582322" @default.
• W2938186903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30997502" @default.
• W2938186903 hasPublicationYear "2019" @default.
• W2938186903 type Work @default.
• W2938186903 sameAs 2938186903 @default.
• W2938186903 citedByCount "17" @default.
• W2938186903 countsByYear W29381869032019 @default.
• W2938186903 countsByYear W29381869032020 @default.
• W2938186903 countsByYear W29381869032021 @default.
• W2938186903 countsByYear W29381869032022 @default.
• W2938186903 countsByYear W29381869032023 @default.
• W2938186903 crossrefType "journal-article" @default.
• W2938186903 hasAuthorship W2938186903A5001653266 @default.
• W2938186903 hasAuthorship W2938186903A5030338003 @default.
• W2938186903 hasAuthorship W2938186903A5054527620 @default.
• W2938186903 hasAuthorship W2938186903A5085703576 @default.
• W2938186903 hasBestOaLocation W29381869031 @default.
• W2938186903 hasConcept C104317684 @default.
• W2938186903 hasConcept C118346598 @default.
• W2938186903 hasConcept C153957851 @default.
• W2938186903 hasConcept C2777576037 @default.
• W2938186903 hasConcept C2779810333 @default.
• W2938186903 hasConcept C54355233 @default.
• W2938186903 hasConcept C54458228 @default.
• W2938186903 hasConcept C64962909 @default.
• W2938186903 hasConcept C67705224 @default.
• W2938186903 hasConcept C86803240 @default.
• W2938186903 hasConcept C94671646 @default.
• W2938186903 hasConceptScore W2938186903C104317684 @default.
• W2938186903 hasConceptScore W2938186903C118346598 @default.
• W2938186903 hasConceptScore W2938186903C153957851 @default.
• W2938186903 hasConceptScore W2938186903C2777576037 @default.
• W2938186903 hasConceptScore W2938186903C2779810333 @default.

• next