Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938204450> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2938204450 abstract "Background Retinoblastoma protein (RB) regulates nucleosome/chromatin structures and is linked to tumor suppression. It regulates the cell cycle by repression of E2F transcription factor and stabilization of heterochromatin. Because SLE is the prototypic autoimmune disease with autoantibodies against the nucleosome and chromatin, the presence of anti-RB antibodies and the association with disease manifestations were examined. Methods 222 SLE patients from the Hopkins longitudinal cohort seen consecutively in clinic were studied (85% female, 94% Caucasian, mean age 51 years). Anti-RB antibodies were assayed by immunoprecipitation of 35S-methionine-labeled protein generated by in vitro transcription and translation from full length human cDNA. Odds ratios and p-values for univariate analyses were calculated using Fishers exact t-test. Exact logistic regression and odds ratios were calculated for the multi-variate model due to a cell frequency of zero for proteinuria ever and positive anti-RB antibody status. Results Anti-RB antibodies were present in 8.6% of these SLE patients, 6.3% with medium-high titer. Univariate associations with SLE manifestations for the medium-high titer positive patients are included in table 1. Of note, medium/high titer anti-RB antibodies were never found in patients with proteinuria (p=0.0028). In a multi-variate model for proteinuria, anti-RB antibodies remained negatively associated (OR 0.1112, p=0.016) after correction for female gender (OR 0.417, p=0.0498), ethnicity (Caucasian, OR 0.288, p=0.0833), low anti-dsDNA ever (OR 1.806, p=0.1192), anti-Sm positive ever (OR 1.273, p=0.7127) and low complement ever (OR 2.111, p=0.0377). Conclusions Anti-RB antibodies are a novel specificity not previously described in SLE. These antibodies are strongly negatively associated with lupus nephritis, even in multivariate models that include other variables (female gender, Caucasian ethnicity, anti-dsDNA, anti-Sm, and low complement). Intriguingly, anti-RB antibodies are positively associated with stroke in SLE. Additional studies are warranted to understand the mechanism of this finding. Funding Source(s): The Hopkins Lupus Cohort was funded by NIH Grant R01-AR069572." @default.
- W2938204450 created "2019-04-25" @default.
- W2938204450 creator A5004540531 @default.
- W2938204450 creator A5008833389 @default.
- W2938204450 creator A5012925907 @default.
- W2938204450 creator A5027453586 @default.
- W2938204450 creator A5082713013 @default.
- W2938204450 date "2019-04-01" @default.
- W2938204450 modified "2023-09-27" @default.
- W2938204450 title "4 Anti-retinoblastoma protein antibodies are negatively associated with lupus nephritis" @default.
- W2938204450 doi "https://doi.org/10.1136/lupus-2019-lsm.4" @default.
- W2938204450 hasPublicationYear "2019" @default.
- W2938204450 type Work @default.
- W2938204450 sameAs 2938204450 @default.
- W2938204450 citedByCount "0" @default.
- W2938204450 crossrefType "proceedings-article" @default.
- W2938204450 hasAuthorship W2938204450A5004540531 @default.
- W2938204450 hasAuthorship W2938204450A5008833389 @default.
- W2938204450 hasAuthorship W2938204450A5012925907 @default.
- W2938204450 hasAuthorship W2938204450A5027453586 @default.
- W2938204450 hasAuthorship W2938204450A5082713013 @default.
- W2938204450 hasBestOaLocation W29382044501 @default.
- W2938204450 hasConcept C121608353 @default.
- W2938204450 hasConcept C126322002 @default.
- W2938204450 hasConcept C156957248 @default.
- W2938204450 hasConcept C159654299 @default.
- W2938204450 hasConcept C163764329 @default.
- W2938204450 hasConcept C203014093 @default.
- W2938204450 hasConcept C2776062698 @default.
- W2938204450 hasConcept C2779134260 @default.
- W2938204450 hasConcept C2779561371 @default.
- W2938204450 hasConcept C2779912601 @default.
- W2938204450 hasConcept C2780091579 @default.
- W2938204450 hasConcept C29537977 @default.
- W2938204450 hasConcept C71924100 @default.
- W2938204450 hasConceptScore W2938204450C121608353 @default.
- W2938204450 hasConceptScore W2938204450C126322002 @default.
- W2938204450 hasConceptScore W2938204450C156957248 @default.
- W2938204450 hasConceptScore W2938204450C159654299 @default.
- W2938204450 hasConceptScore W2938204450C163764329 @default.
- W2938204450 hasConceptScore W2938204450C203014093 @default.
- W2938204450 hasConceptScore W2938204450C2776062698 @default.
- W2938204450 hasConceptScore W2938204450C2779134260 @default.
- W2938204450 hasConceptScore W2938204450C2779561371 @default.
- W2938204450 hasConceptScore W2938204450C2779912601 @default.
- W2938204450 hasConceptScore W2938204450C2780091579 @default.
- W2938204450 hasConceptScore W2938204450C29537977 @default.
- W2938204450 hasConceptScore W2938204450C71924100 @default.
- W2938204450 hasLocation W29382044501 @default.
- W2938204450 hasOpenAccess W2938204450 @default.
- W2938204450 hasPrimaryLocation W29382044501 @default.
- W2938204450 hasRelatedWork W1975785785 @default.
- W2938204450 hasRelatedWork W1991234669 @default.
- W2938204450 hasRelatedWork W2027351920 @default.
- W2938204450 hasRelatedWork W2042549844 @default.
- W2938204450 hasRelatedWork W2042562308 @default.
- W2938204450 hasRelatedWork W2080879115 @default.
- W2938204450 hasRelatedWork W2320451797 @default.
- W2938204450 hasRelatedWork W2329258142 @default.
- W2938204450 hasRelatedWork W2355383728 @default.
- W2938204450 hasRelatedWork W2367736066 @default.
- W2938204450 hasRelatedWork W2388451375 @default.
- W2938204450 hasRelatedWork W2389059287 @default.
- W2938204450 hasRelatedWork W2552549337 @default.
- W2938204450 hasRelatedWork W2739959353 @default.
- W2938204450 hasRelatedWork W2927890984 @default.
- W2938204450 hasRelatedWork W2950789515 @default.
- W2938204450 hasRelatedWork W2979804646 @default.
- W2938204450 hasRelatedWork W3115349294 @default.
- W2938204450 hasRelatedWork W3124166340 @default.
- W2938204450 hasRelatedWork W3152164942 @default.
- W2938204450 isParatext "false" @default.
- W2938204450 isRetracted "false" @default.
- W2938204450 magId "2938204450" @default.
- W2938204450 workType "article" @default.