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- W2938209869 abstract "Altered systemic oxidative stress is a consequence of environmental exposures and diseases, among other stress factors. The extent of oxidative stress in humans is assessed through the analysis of oxidative stress biomarkers (OSBs) in biospecimens such as urine. Allantoin is an OSB, a specific product of the oxidation of uric acid, that is measurable in urine. In this study, concentrations and inter- and intraindividual variability in urinary concentrations of allantoin were determined in healthy individuals. The results were compared with those found for other OSBs of lipids, proteins, and DNA in the same set of samples. Allantoin was found in all urine samples (N = 515), at concentrations that ranged from 0.88 to 41.7 mmol mol–1 creatinine (0.90 to 112 μg mL–1 urine). The intraclass correlation coefficient (ICC) of urinary allantoin measured in samples collected longitudinally for over a month from 19 individuals (0.74 for creatinine corrected and 0.80 for volumetric concentrations) showed an excellent reliability and notable interindividual variability. Among eight biomarkers measured in the same set of urine samples, allantoin was the predominant one, and it was positively and significantly correlated with urinary creatinine and other OSBs of lipids, proteins, and DNA. We suggest that urinary allantoin is a suitable biomarker of oxidative stress because of its requirement for simple and rapid analysis and long-term reliability/reproducibility as determined by high ICC values." @default.
- W2938209869 created "2019-04-25" @default.
- W2938209869 creator A5049769481 @default.
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- W2938209869 date "2019-04-09" @default.
- W2938209869 modified "2023-09-30" @default.
- W2938209869 title "Allantoin as a Marker of Oxidative Stress: Inter- and Intraindividual Variability in Urinary Concentrations in Healthy Individuals" @default.
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- W2938209869 doi "https://doi.org/10.1021/acs.estlett.9b00142" @default.
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