Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938214599> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2938214599 endingPage "1257" @default.
- W2938214599 startingPage "1256" @default.
- W2938214599 abstract "A new generation of novel cannabinoid compounds have been developed as marijuana substitutes to avoid drug control laws and cannabinoid blood tests. 5F-MDMB-PINACA (also known as 5F-ADB, 5F-ADB-PINACA), MDMB-CHIMICA, MDMB-FUBINACA, ADB-FUBINACA, and AMB-FUBINACA (also known as FUB-AMB, MMB-FUBINACA) were tested for in vivo cannabinoid-like effects to assess their abuse liability. Locomotor activity in mice was tested to screen for locomotor depressant effects and to identify behaviorally-active dose ranges and times of peak effect. Discriminative stimulus effects were tested in rats trained to discriminate Δ9-tetrahydrocannabinol (3 mg/kg, 30-min pretreatment). 5F-MDMB-PINACA (ED50 = 1.1 mg/kg) and MDMB-CHIMICA (ED50 = 0.024 mg/kg) produced short-acting (30 min) depression of locomotor activity. ADB-FUBINACA (ED50 = 0.19 mg/kg), and AMB- FUBINACA (ED50 = 0.19 mg/kg) depressed locomotor activity for 60–90 min; whereas MDMB-FUBINACA (ED50 = 0.04 mg/kg) depressed locomotor activity for 150 min. AMB-FUBINACA produced tremors at the highest dose tested. 5F-MDMB-PINACA (ED50 = 0.07), MDMB-CHIMICA (ED50 = 0.01 mg/kg), MDMB-FUBINACA (ED50 = 0.051 mg/kg), ADB-FUBINACA (ED50 = 0.075 mg/kg) and AMB-FUBINACA (ED50 = 0.029) fully substituted for the discriminative stimulus effects of Δ9-THC following 15-min pretreatment. All 5 compounds decreased locomotor activity and produced discriminative stimulus effects similar to those of Δ9-THC, which suggests they may have abuse liability similar to that of Δ9-THC. AMB-FUBINACA may have an increased risk of toxicities in recreational users." @default.
- W2938214599 created "2019-04-25" @default.
- W2938214599 creator A5018128613 @default.
- W2938214599 date "1997-04-01" @default.
- W2938214599 modified "2023-09-23" @default.
- W2938214599 title "Pursuit of ecstasy: The MDMA experience" @default.
- W2938214599 doi "https://doi.org/10.1016/s0277-9536(97)83320-5" @default.
- W2938214599 hasPublicationYear "1997" @default.
- W2938214599 type Work @default.
- W2938214599 sameAs 2938214599 @default.
- W2938214599 citedByCount "0" @default.
- W2938214599 crossrefType "journal-article" @default.
- W2938214599 hasAuthorship W2938214599A5018128613 @default.
- W2938214599 hasConcept C126322002 @default.
- W2938214599 hasConcept C170493617 @default.
- W2938214599 hasConcept C185592680 @default.
- W2938214599 hasConcept C2778961205 @default.
- W2938214599 hasConcept C2779547902 @default.
- W2938214599 hasConcept C2780035454 @default.
- W2938214599 hasConcept C2780557958 @default.
- W2938214599 hasConcept C2780871563 @default.
- W2938214599 hasConcept C2780876324 @default.
- W2938214599 hasConcept C3017944768 @default.
- W2938214599 hasConcept C33070731 @default.
- W2938214599 hasConcept C42533223 @default.
- W2938214599 hasConcept C545542383 @default.
- W2938214599 hasConcept C57022672 @default.
- W2938214599 hasConcept C71924100 @default.
- W2938214599 hasConcept C86803240 @default.
- W2938214599 hasConcept C98274493 @default.
- W2938214599 hasConceptScore W2938214599C126322002 @default.
- W2938214599 hasConceptScore W2938214599C170493617 @default.
- W2938214599 hasConceptScore W2938214599C185592680 @default.
- W2938214599 hasConceptScore W2938214599C2778961205 @default.
- W2938214599 hasConceptScore W2938214599C2779547902 @default.
- W2938214599 hasConceptScore W2938214599C2780035454 @default.
- W2938214599 hasConceptScore W2938214599C2780557958 @default.
- W2938214599 hasConceptScore W2938214599C2780871563 @default.
- W2938214599 hasConceptScore W2938214599C2780876324 @default.
- W2938214599 hasConceptScore W2938214599C3017944768 @default.
- W2938214599 hasConceptScore W2938214599C33070731 @default.
- W2938214599 hasConceptScore W2938214599C42533223 @default.
- W2938214599 hasConceptScore W2938214599C545542383 @default.
- W2938214599 hasConceptScore W2938214599C57022672 @default.
- W2938214599 hasConceptScore W2938214599C71924100 @default.
- W2938214599 hasConceptScore W2938214599C86803240 @default.
- W2938214599 hasConceptScore W2938214599C98274493 @default.
- W2938214599 hasIssue "8" @default.
- W2938214599 hasLocation W29382145991 @default.
- W2938214599 hasOpenAccess W2938214599 @default.
- W2938214599 hasPrimaryLocation W29382145991 @default.
- W2938214599 hasRelatedWork W1522122924 @default.
- W2938214599 hasRelatedWork W2009889040 @default.
- W2938214599 hasRelatedWork W2028151792 @default.
- W2938214599 hasRelatedWork W2079689914 @default.
- W2938214599 hasRelatedWork W2092771906 @default.
- W2938214599 hasRelatedWork W2110790176 @default.
- W2938214599 hasRelatedWork W2137655290 @default.
- W2938214599 hasRelatedWork W2746058256 @default.
- W2938214599 hasRelatedWork W3176176594 @default.
- W2938214599 hasRelatedWork W4247968603 @default.
- W2938214599 hasVolume "44" @default.
- W2938214599 isParatext "false" @default.
- W2938214599 isRetracted "false" @default.
- W2938214599 magId "2938214599" @default.
- W2938214599 workType "article" @default.