FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2938238487> ?p ?o ?g. }

• W2938238487 endingPage "29" @default.
• W2938238487 startingPage "25" @default.
• W2938238487 abstract "Tyrosyl-DNA phosphodiesterase I (TDP1), like most DNA repair associated proteins, is not essential for cell viability. However, dysfunctioning TDP1 or ATM (ataxia telangiectasia mutated) results in autosomal recessive neuropathology with similar phenotypes, including cerebellar atrophy. Dual inactivation of TDP1 and ATM causes synthetic lethality. A TDP1H493R catalytic mutant is associated with spinocerebellar ataxia with axonal neuropathy (SCAN1), and stabilizes the TDP1 catalytic obligatory enzyme-DNA covalent complex. The ATM kinase activates proteins early on in response to DNA damage. Tdp1-/- and Atm-/- mice exhibit accumulation of DNA topoisomerase I-DNA covalent complexes (TOPO1-cc) explicitly in neuronal tissue during development. TDP1 resolves 3'- and 5'-DNA adducts including trapped TOPO1-cc and TOPO1 protease resistant peptide-DNA complex. ATM appears to regulate the response to TOPO1-cc via a noncanonical function by regulating SUMO/ubiquitin-mediated TOPO1 degradation. In conclusion, TDP1 and ATM are critical factors for neuronal cell viability via two independent but cooperative pathways." @default.
• W2938238487 created "2019-04-25" @default.
• W2938238487 creator A5079685102 @default.
• W2938238487 date "2016-08-01" @default.
• W2938238487 modified "2023-10-13" @default.
• W2938238487 title "Tyrosyl-DNA Phosphodiesterase I a critical survival factor for neuronal development and homeostasis" @default.
• W2938238487 cites W1666958381 @default.
• W2938238487 cites W1965406938 @default.
• W2938238487 cites W1970561675 @default.
• W2938238487 cites W1972963751 @default.
• W2938238487 cites W1974051214 @default.
• W2938238487 cites W1975426967 @default.
• W2938238487 cites W1996432141 @default.
• W2938238487 cites W2005110566 @default.
• W2938238487 cites W2007047273 @default.
• W2938238487 cites W2014014132 @default.
• W2938238487 cites W2027867457 @default.
• W2938238487 cites W2028876509 @default.
• W2938238487 cites W2030607711 @default.
• W2938238487 cites W2035546788 @default.
• W2938238487 cites W2044065603 @default.
• W2938238487 cites W2046770300 @default.
• W2938238487 cites W2049118227 @default.
• W2938238487 cites W2061083265 @default.
• W2938238487 cites W2062445688 @default.
• W2938238487 cites W2063223977 @default.
• W2938238487 cites W2069298164 @default.
• W2938238487 cites W2071125292 @default.
• W2938238487 cites W2071457560 @default.
• W2938238487 cites W2072358340 @default.
• W2938238487 cites W2074916944 @default.
• W2938238487 cites W2076418100 @default.
• W2938238487 cites W2079456387 @default.
• W2938238487 cites W2082761467 @default.
• W2938238487 cites W2085712777 @default.
• W2938238487 cites W2088393598 @default.
• W2938238487 cites W2091859537 @default.
• W2938238487 cites W2097738814 @default.
• W2938238487 cites W2102043258 @default.
• W2938238487 cites W2104359749 @default.
• W2938238487 cites W2124624490 @default.
• W2938238487 cites W2131418908 @default.
• W2938238487 cites W2132600317 @default.
• W2938238487 cites W2134939911 @default.
• W2938238487 cites W2139777089 @default.
• W2938238487 cites W2140216668 @default.
• W2938238487 cites W2144255214 @default.
• W2938238487 cites W2160763902 @default.
• W2938238487 cites W2167505302 @default.
• W2938238487 cites W2180703443 @default.
• W2938238487 cites W2339129870 @default.
• W2938238487 cites W2417125981 @default.
• W2938238487 doi "https://doi.org/10.29245/2572.942x/2016/5.1048" @default.
• W2938238487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5064944" @default.
• W2938238487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27747316" @default.
• W2938238487 hasPublicationYear "2016" @default.
• W2938238487 type Work @default.
• W2938238487 sameAs 2938238487 @default.
• W2938238487 citedByCount "2" @default.
• W2938238487 countsByYear W29382384872017 @default.
• W2938238487 countsByYear W29382384872020 @default.
• W2938238487 crossrefType "journal-article" @default.
• W2938238487 hasAuthorship W2938238487A5079685102 @default.
• W2938238487 hasBestOaLocation W29382384871 @default.
• W2938238487 hasConcept C104317684 @default.
• W2938238487 hasConcept C134935766 @default.
• W2938238487 hasConcept C143425029 @default.
• W2938238487 hasConcept C147897179 @default.
• W2938238487 hasConcept C153911025 @default.
• W2938238487 hasConcept C185592680 @default.
• W2938238487 hasConcept C2779500118 @default.
• W2938238487 hasConcept C34688535 @default.
• W2938238487 hasConcept C552990157 @default.
• W2938238487 hasConcept C55493867 @default.
• W2938238487 hasConcept C68748289 @default.
• W2938238487 hasConcept C86803240 @default.
• W2938238487 hasConcept C95444343 @default.
• W2938238487 hasConceptScore W2938238487C104317684 @default.
• W2938238487 hasConceptScore W2938238487C134935766 @default.
• W2938238487 hasConceptScore W2938238487C143425029 @default.
• W2938238487 hasConceptScore W2938238487C147897179 @default.
• W2938238487 hasConceptScore W2938238487C153911025 @default.
• W2938238487 hasConceptScore W2938238487C185592680 @default.
• W2938238487 hasConceptScore W2938238487C2779500118 @default.
• W2938238487 hasConceptScore W2938238487C34688535 @default.
• W2938238487 hasConceptScore W2938238487C552990157 @default.
• W2938238487 hasConceptScore W2938238487C55493867 @default.
• W2938238487 hasConceptScore W2938238487C68748289 @default.
• W2938238487 hasConceptScore W2938238487C86803240 @default.
• W2938238487 hasConceptScore W2938238487C95444343 @default.
• W2938238487 hasIssue "5" @default.
• W2938238487 hasLocation W29382384871 @default.
• W2938238487 hasLocation W29382384872 @default.
• W2938238487 hasLocation W29382384873 @default.
• W2938238487 hasLocation W29382384874 @default.
• W2938238487 hasOpenAccess W2938238487 @default.
• W2938238487 hasPrimaryLocation W29382384871 @default.
• W2938238487 hasRelatedWork W1588345044 @default.

• next