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• W2938242022 abstract "Objective . The purpose of this study was to compare matrix metalloproteinase-12 (MMP-12), neutrophil elastase (NE), and tissue inhibitor of metalloproteinase-4 (TIMP-4) in peripheral blood of patients with chronic obstructive pulmonary disease (COPD) and controls. At the same time, MMP-12, NE, and TIMP-4 in exhaled breath condensate (EBC) were also evaluated. Methods . Peripheral blood and EBC samples from COPD patients and healthy controls were collected. In serum and EBC, MMP-12, NE, and TIMP-4 proteins were detected by enzyme-linked immunoassays. The mRNA expression levels of MMP-12, NE, and TIMP-4 in peripheral blood mononuclear cells (PBMCs) were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). Results . The concentration of TIMP-4 protein in EBC was lower in patients with COPD (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>). MMP-12 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.046</mml:mn></mml:math>), NE (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.027</mml:mn></mml:math>), and TIMP-4 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.005</mml:mn></mml:math>) proteins in serum of patients with COPD showed higher levels of concentration. The mRNA of MMP-12 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0067</mml:mn></mml:math>), NE (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0058</mml:mn></mml:math>), and TIMP-4 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0006</mml:mn></mml:math>) in PBMCs of COPD patients showed higher expression levels. Compared with stable patients, mRNA expression level of NE (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.033</mml:mn></mml:math>) in PBMCs of patients with acute exacerbation of COPD was increased. There were differences in the ratio of MMP-12/TIMP-4 in PBMC (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0055</mml:mn></mml:math>), serum (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0427</mml:mn></mml:math>), and EBC (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0035</mml:mn></mml:math>) samples between COPD patients and healthy controls. The mRNA expression of MMP-12 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mi>r</mml:mi><mml:mrow><mml:mo>=</mml:mo></mml:mrow><mml:mrow><mml:mo>−</mml:mo></mml:mrow><mml:mn>0.3958</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0186</mml:mn></mml:math>) and NE (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M14><mml:mi>r</mml:mi><mml:mrow><mml:mo>=</mml:mo></mml:mrow><mml:mrow><mml:mo>−</mml:mo></mml:mrow><mml:mn>0.3694</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M15><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0290</mml:mn></mml:math>) in COPD patients was negatively correlated with pulmonary function. However, the mRNA expression of TIMP-4 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M16><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.2871</mml:mn></mml:math>, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M17><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0945</mml:mn></mml:math>) in PBMCs was not correlated with the FEV 1 of the pulmonary function. Serum MMP-12 level was positively correlated with the MMP-12 level in EBC (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M18><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0387</mml:mn></mml:math>). The level of TIMP-4 in serum was not correlated with the level in the EBC sample (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M19><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.4332</mml:mn></mml:math>). Conclusion . The expression levels of MMP-12, NE, and TIMP-4 in PBMCs and serum were elevated in COPD patients. In PBMCs of COPD patients, the mRNA expression level of NE may predict acute exacerbation, and MMP-12 mRNA expression level may be used to reflect the severity of airflow limitation. However, to better assess their diagnostic or prognostic value, larger studies are necessary." @default.
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• W2938242022 date "2019-04-17" @default.
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• W2938242022 title "Expressions of MMP-12, TIMP-4, and Neutrophil Elastase in PBMCs and Exhaled Breath Condensate in Patients with COPD and Their Relationships with Disease Severity and Acute Exacerbations" @default.
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• W2938242022 doi "https://doi.org/10.1155/2019/7142438" @default.
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